Use of solid-phase inhomogeneities to increase the efficiency of ultrasonic therapy of oncological diseases

Николаев, А. Л.; Гопин, А. В.; Bozhevol’nov, V. E.; Трещалина, Е. М.; Andronova, N. A.; Мелихов, И. В.

doi:10.1134/s1063771009040149

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…The ability to achieve sonosensitization using HA has not previously been reported and thus this finding represents an important advancement in the development of ultrasound responsive materials for bone repair applications. While the mechanisms involved in ultrasound‐triggered release of therapeutic agents from hydrogels have yet to be fully elucidated, studies report that both mechanical and thermal effects play a role 11,15 . The ultrasound protocol applied here has previously been shown to be effective at triggering release from alginate hydrogels while maintaining the temperature below 37°C 9 .…”

Section: Discussionmentioning

confidence: 93%

“…A further challenge in the development of ultrasound‐triggered hydrogel systems relates to the low ultrasonic adsorption properties of many hydrogels, which limits their responsiveness to ultrasound. Recently 'solid‐phase sonosensitization' has been reported, whereby solid‐phase inclusions are incorporated into hydrogels to achieve a local increase in ultrasound sensitivity 15 . Osminkina et al .…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

et al. 2021

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While bones have the innate capability to physiologically regenerate, in certain cases regeneration is suboptimal, too slow, or does not occur. Biomaterials‐based growth factor delivery systems have shown potential for the treatment of challenging bone defects, however, achieving controlled growth factor release remains a challenge. The objective of this study was to develop a thermally responsive hydrogel for bone regeneration capable of ultrasound‐triggered on‐demand delivery of therapeutic agents. Furthermore, it was hypothesized that incorporation of hydroxyapatite (HA) into the hydrogel could increase sonosensitization, augmenting ultrasound sensitivity to enable controlled therapeutic release to the target tissue. Alginate thermally responsive P(Alg‐g‐NIPAAm) hydrogels were fabricated and varying quantities of HA (1, 3, 5, and 7% wt./vol.) incorporated. All hydrogels were highly injectable (maximum injection force below 6.5 N) and rheological characterization demonstrated their ability to gel at body temperature. The study demonstrated the ultrasound‐triggered release of sodium fluorescein (NaF), bovine serum albumin (BSA), and bone morphogenetic protein 2 (BMP‐2) from the hydrogels. Release rates of BSA and BMP‐2 were significantly enhanced in the HA containing hydrogels, confirming for the first time the role of HA as a son sensitizer. Together these results demonstrate the potential of these ultrasound‐triggered thermally responsive hydrogels for on‐demand delivery of therapeutic agents for bone regeneration.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

et al. 2021

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“…It is of interest to find out the mechanism that is responsible for the appearance of the sonodynamic effect. Previously, we discussed two mechanisms that can lead to the destruction of cancer cells [42,43]. The first mechanism is cavitation and the use of aggregates of Ce6 molecules to enhance the cavitation effect that leads to the destruction of cancerous [44,45].…”

Section: Discussionmentioning

confidence: 99%

Sonodynamic effect in A375 melanoma cells with Chlorin e6 induced by 20 kHz ultrasound

Dadadzhanova¹,

Kolesova²,

Маслов³

et al. 2021

Preprint

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In this research, combined effect of chlorin e6 and noninvasive 20 kHz, lowpowered ultrasound on melanoma cells is proposed for the first time. The proposed combination incorporates the application of safe low-frequency ultrasound that is used for transdermal drug delivery. We demonstrate that impact of the 20 kHz ultrasound on chlorin e6 leads to strong sonodynamic effect in melanoma cells. We also show that chlorin e6 keeps its monomeric form in the cells and does not aggregate after exposure to ultrasound. We propose a two-step model where sonoluminescence serves as an internal light source for the chlorin e6 photoactivation.

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“…It is of interest to find out the mechanism that is responsible for the appearance of the sonodynamic effect. Previously, we discussed two mechanisms that can lead to the destruction of cancer cells [50,51]. The first mechanism is cavitation and the use of aggregates of Ce6 molecules to enhance the cavitation effect that leads to the destruction of cancerous cells [52,53].…”

Section: Sdt Test On A375 Cellsmentioning

confidence: 99%

Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound

Dadadzhanova¹,

Kolesova²,

Маслов³

et al. 2021

J. Phys. D: Appl. Phys.

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In this research, combined effect of chlorin e6 and noninvasive 20 kHz, low-powered ultrasound on melanoma cells is proposed for the first time. The proposed combination incorporates the application of safe low-frequency ultrasound that is used for transdermal drug delivery. We demonstrate that impact of the 20 kHz ultrasound on chlorin e6 leads to strong sonodynamic effect in melanoma cells. We also show that chlorin e6 keeps its monomeric form in the cells and does not aggregate after exposure to ultrasound. We propose a two-step model where sonoluminescence serves as an internal light source for the chlorin e6 photoactivation.

show abstract

Use of solid-phase inhomogeneities to increase the efficiency of ultrasonic therapy of oncological diseases

Cited by 11 publications

References 16 publications

Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

Sonodynamic effect in A375 melanoma cells with Chlorin e6 induced by 20 kHz ultrasound

Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound

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