Use of sol–gel‐derived titania coating for direct soft tissue attachment

Abstract

A firm bond between an implant and the surrounding soft tissue is important for the performance of many medical devices (e.g., stents, canyls, and dental implants). In this study, the performance of nonresorbable and reactive sol-gel-derived nano-porous titania (TiO(2)) coatings in a soft tissue environment was investigated. A direct attachment between the soft tissue and the sol-gel-derived titania coatings was found in vivo after 2 days of implantation, whereas the titanium control implants showed no evidence of soft tissue attachment. The coated implants were in immediate contact with the connective tissue, whereas the titanium controls formed a gap and a fibrous capsule on the implant-tissue interface. The good soft tissue attachment of titania coatings may result from their ability to initiate calcium phosphate nucleation and growth on their surfaces (although the formation of poorly crystalline bonelike apatite does not occur). Thus, the formation of a bonelike CaP layer is not crucial for their integration in soft tissue. The formation of bonelike apatite was hindered by the adsorption of proteins onto the initially formed amorphous calcium phosphate growth centers, thus preventing the dissolution/reprecipitation processes required for the formation of poorly crystalline bonelike apatite. These findings might open novel application areas for sol-gel-derived titania-based coatings.

Improved brushing durability of titanium dioxide coating on polymethyl methacrylate substrate by prior treatment with acryloxypropyl trimethoxysilane-based agent for denture application

“…Coating a titanium oxide layer onto a substrate can confer biomedical materials with desirable properties such as high biological affinity and bioactivity [1][2][3][4][5][6][7] . Such coatings have also attracted great interest in terms of the potential for practical application offered by their antimicrobial and antifouling properties 8,9) , as titanium dioxide (TiO2) induces oxidization on excitation by ultraviolet irradiation [10][11][12] .…”

Cytokine induction of sol–gel-derived TiO₂ and SiO₂ coatings on metallic substrates after implantation to rat femur

“…It was previously demonstrated that solgel-derived oxide films were bioactive in vitro and in vivo, and could induce bone attachment to the metallic materials, which confirmed their suitability as bone implants. [22][23][24][25][26] The sol-gel method of SiO 2 -and titania-based coating synthesis is inexpensive and allows to control the film properties by changing the solution composition or deposition process details (eg, homogenous physicochemical structure, roughness, Young's modulus, etc). It also affects the biomaterial's surface features; topography, roughness, and wettability.…”

Titania and Titania-Silica Coatings for Titanium: Comparison of Ectopic Bone Formation within Cell-Seeded Scaffolds

“…30 On the other hand, nonresorbable solgel TiO 2 coatings have been shown to increase both bone 20 and soft-tissue 31 attachment to titanium implants. Under culture conditions, osteoblast response on planar surfaces, 24 but not in porous scaffolds, 25 was found to be further enhanced by incorporation of a reactive silica phase in the coating.…”