Use of single dose prophylactic magnesium sulphate in severe preeclampsia in preventing seizures

Bembalgi, Shobha; Kanwal, Preet

doi:10.18203/2320-1770.ijrcog20162106

Cited by 1 publication

(2 citation statements)

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“…[ 9 10 15 17 ] Perhaps, the non observation of such side effects in this study may strengthen the adoption of only the loading dose, moreso that it demonstrated similar efficacy with Pritchard regimen. In addition, the duration of hospital stay had been proven in the previous studies to be shorter in the loading dose-only arm,[ 15 19 20 ] as was observed in this study.…”

Section: Discussionsupporting

confidence: 75%

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A randomized controlled trial of loading dose alone versus pritchard regimen of magnesium sulphate, for seizure prophylaxis in severe preeclampsia

Obanimoh¹,

Isah²,

Abdullahi³

et al. 2023

Ann Afr Med

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Background: Preeclampsia poses a significant risk of maternal and neonatal morbidity and mortality. Magnesium sulfate superiority for seizure prophylaxis in severe preeclampsia has been proven globally. However, the search for the lowest effective dose is an area of continuing research. Aim: The aim of this study was to compare the effectiveness of loading dose with the Pritchard regimen of magnesium sulfate for seizure prophylaxis in severe preeclampsia. Materials and Methods: A total of 138 eligible women after 28-week gestation with severe preeclampsia were randomized to either receiving a single loading dose of MgSO 4 (study arm: n = 69) or Pritchard regimen of MgSO 4 (control: n = 69). The effectiveness was assessed by the development of seizure. The results obtained were analyzed using SPSS version 21. Categorical variables were analyzed using the Chi-square test and normally distributed continuous variables were analyzed with t -test and Fisher's exact test. P < 0.05 was considered statistical significance. Results: There were no significant differences between those who received only the loading dose when compared with those who had Pritchard regimen other than a single recorded convulsion among the control group ( P = 0.316). Similarly, except for the duration of hospital stay which was significantly longer in the Pritchard group ( P = 0.019), both the arms of the study shared similar maternal and fetal outcomes. Conclusion: This study suggests the effectiveness of just the loading dose of magnesium sulfate when compared with the standardized Pritchard regimen in the prevention of seizure among women with severe preeclampsia. The study also demonstrated safety and similarity in fetal-maternal outcome. The loading dose only had an added advantage of shorter duration of hospital stay.

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Section: Discussionsupporting

confidence: 75%

“…[ 17 18 ] Only a few randomized studies have elucidated the efficacy of lower doses of MgSO 4 as seizure prophylaxis in severe preeclampsia. [ 17 19 20 21 ] It appears, therefore, that the search for the lowest effective dose to prevent convulsion remains an area of continuing research.…”

Section: Introductionmentioning

confidence: 99%