Use of Single- and Multi-Locus and Polymerase Chain Reaction Systems for Zygosity Determination - Clinical Application in Twins with Clefts of the Lip and Palate
Abstract:Precision of zygosity determination in twins can be improved by the use of modern methods of DNA analysis. The clinical application of 4 single-(SLS) and 2 multi-locus (MLS), and 6 PCR (polymerase chain reaction) systems for zygosity determination in 12 twin pairs with oral clefts was compared with regard to the quality and quantity of sample material required and the probability of error in monozygosity determination. PCR systems proved to be superior to SLS or MLS, as DNA sampling is much more convenient, wh… Show more
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