Abstract:Introduction
Warfarin-dosing algorithms combine clinical factors and dosing history with the current international normalized ratio (INR) to estimate the therapeutic warfarin dose. Unfortunately, these approaches can result in an overdose if the INR is spuriously low. Our goal was to develop an alert mechanism based on prior INRs in addition to the current INR.
Patients and Methods
Using data from the Genetics Informatics Trial (GIFT), we analyzed warfarin dose estimates for days 3 through 11 that were ≥ 10%… Show more
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