Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies

Hauzman, Erik; Fedorcsák, Péter; Klinga, K.; Papp, Zoltán; Rabe, T.; Strowitzki, T.; Urbancsek, János

doi:10.1016/j.fertnstert.2003.05.007

Cited by 32 publications

(15 citation statements)

References 27 publications

(37 reference statements)

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“…The results with single embryo transfer were not so optimistic in our study, as women in the mentioned age groups conceived only in 12% of the cases. Our results reflect the findings by other scientists, reporting on the predictive value of the number of transferred embryos [10,11]. Of course, the number of transferred embryos is related with multiple births.…”

Section: Discussionsupporting

confidence: 91%

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Impact of quantitative parameters, such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation, on clinical pregnancy rates in ART

Čerkienė

Usonienė

Amsiejiene

et al. 2015

Gynecological Endocrinology

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Objective: To estimate the impact of quantitative parameters such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation on clinical pregnancies in assisted reproductive technology (ART). Design: We used the database of fertility clinic on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment cycles from year 2000 to 2010. Follicular fluids containing oocyte-cumulus complexes were recovered by a single lumen follicle aspiration needle, and IVF or ICSI procedure was used depending on infertility indications. Fertilization determination was performed on the second day. Zygotes were transferred into fresh medium and cultivated until the embryo transfer procedure. According to morphological criteria, the best quality embryos were transferred into uterus on the second or third day. Surplus embryos were frozen by slow freezing or by vitrification. We evaluated only clinical pregnancies that were diagnosed by ultrasonography. Patients: We allocated all 1161 women cohort into three age groups: 671 women were535; 397 were 35-40 years old and 93 women were 440. Indications for IVF treatment were as follows: mechanical factor (436 cases), male infertility (361 cases), idiopathic infertility (129 cases), endometriosis (78 cases), immunological infertility (14 cases), anovulation (28 cases), and other indications (28 cases). There were no data about the cause of infertility of 87 patients. The stimulation protocol was composed from gonadotropin hormone stimulation with antagonist or agonist supplementation. The triggering of luteinizing hormone (LH) surge was performed by recombinant human chorionic gonadotropin (hCG). The clinical pregnancy rates were: 42.2% (283/671) for women 535, 31.2% (124/397) for women 35-40-year-old and 16.1% (15/93) for women 440. Interventions: All materials and methods that we used were based on results from our daily practice in IVF clinic and have no experimental design. Main outcome measures: We evaluated clinical pregnancies in terms of the number of obtained oocytes, the amount of transferred embryos and the availability of surplus embryos for freezing. The number of retrieved oocytes was divided as follows: 1-5 (group I); 6-10 (group II); 11 (group III). The number of transferred embryos was from 1 to 3. Cases at which cryopreservation of embryos was not performed were evaluated as well. Results: For women 535 and 35-40 years old, the highest percentage of pregnancies was achieved when 11 and more oocytes were obtained. Differences in women under 35 between groups were statistically significant. Statistically significant differences in clinical pregnancies depend on the number of transferred embryos in the age groups of 535 and 35-40. Women 535 and 35-40 years old, with the availability of surplus embryos for freezing, had better chances for pregnancy compared with women, who had no excess embryos for freezing. Conclusions: The number of obtained oocytes, the number of transferred embryos and the avai...

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Section: Discussionsupporting

confidence: 91%

“…There was only one woman 440 with 411 oocytes and the causes were obvious. Successful IVF cycle is based on an average numbers of oocytes [4][5][6][7][8][9][10][11][12][13][14] and it has been proven as the ''golden standard'' [14]. We found that the optimum results in pregnancy rates in IVF require more than 11 oocytes.…”

Section: Discussionmentioning

confidence: 99%

Impact of quantitative parameters, such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation, on clinical pregnancy rates in ART

Čerkienė

Usonienė

Amsiejiene

et al. 2015

Gynecological Endocrinology

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“…Dimeric inhibin A was measured in duplicate using a solid-phase sandwich ELISA (Oxford Bio-Innovation, Oxford, UK), which uses two monoclonal antibodies, as described elsewhere [26]. Both intraassay and interassay coefficients of variation were <20%, and the sensitivity of the assay was 3.9 pg/mL.…”

Section: Hormone Assaysmentioning

confidence: 99%

Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio

Hauzman

Fancsovits

Murber

et al. 2006

J Assist Reprod Genet

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Purpose: To test whether serum inhibin levels are related to differences in gonadotropin concentrations between patients with an elevated LH-to-FSH ratio (ELF patients) and controls.Methods: 32 ELF patients were matched with controls by age, body mass index (BMI), and cycle length.Results: No statistically significant difference was found in follicular-phase inhibin B levels or midluteal inhibin A levels between cases and controls. Significant negative correlation was observed between follicular-phase inhibin B concentrations and BMI in ELF patients but not among controls. LH and FSH were positively related to inhibin B levels in ELF patients. Midluteal inhibin A correlated with sex hormone-binding globulin in controls but not in ELF patients.Conclusions: Neither follicular-phase inhibin B levels nor midluteal inhibin A levels are characteristic of patients with an elevated LH-to-FSH ratio. Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome.

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“…Ovarian stimulation, ovulation induction, and oocyte pickup were carried out as described elsewhere (11). Retrieved oocytes were fertilized with either IVF or ICSI technique.…”

Section: Methodsmentioning

confidence: 99%

Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

Hauzman

Lagarde

Nagy

et al. 2005

J Assist Reprod Genet

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Use of serum inhibin A and human chorionic gonadotropin measurements to predict the outcome of in vitro fertilization pregnancies

Cited by 32 publications

References 27 publications

Impact of quantitative parameters, such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation, on clinical pregnancy rates in ART

Impact of quantitative parameters, such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation, on clinical pregnancy rates in ART

Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio

Prognostic value of serum CA-125 measurements on stimulation day 1 and on the day of oocyte pickup in the prediction of IVF treatment outcome

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