Use of self-expanding, hydrophilic osmotic expanders (hydrogel) in the reconstruction of congenital clinical anophthalmos

Mazzoli, Robert A.; Raymond, Wilfred W.; Ainbinder, Darryl J.; Hansen, Elizabeth

doi:10.1097/01.icu.0000138618.61059.4c

Cited by 65 publications

(32 citation statements)

References 26 publications

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“…Because of the hydrogel nature of cartilage, polymers in hydrogel form good candidates for cartilage repair, and they have been extensively investigated in recent years. [41][42][43][44][45][46][47][48][49] Because of their unique properties, hydrogels have been explored for a wide range of biomedical applications, including drug delivery, 50 protein delivery, 51 gene delivery, 52 wound dressing, 53 water elimination for edema, 54 cosmetic reconstruction, 55 contact lenses, 56 and tissue engineering. 49,[57][58][59] One major challenge in employing hydrogels for load-bearing connective tissue repair in cartilage, tendon, intervertebral disk, ligament, and so on, is insufficient mechanical strength.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of biocompatible, degradable, light‐curable, polyurethane‐based elastic hydrogels

Zhang

Wen

2007

J Biomedical Materials Res

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A series of degradable polyurethane-based light-curable elastic hydrogels were synthesized from polycaprolactone diol, polyethylene glycol (PEG), lysine diisocyanate (LDI), and 2-hydroxyethyl methacrylate (HEMA) through UV light initiated polymerization reaction. LDI was used as hard segment and polycaprolactone (PCL) and/or PEG were used as soft segments. By changing the PCL to PEG ratio during the prepolymer synthesis, polyurethanes with different soft segmental structures, hydrophilicity, and cytophilicity were obtained after light-initiated polymerization. The chemical structures of the synthesized polymers were characterized using differential scanning calorimetry and Fourier transform infrared spectroscopy. Physical properties such as swelling, mechanical properties, and in vitro degradation were evaluated. Materials containing a higher ratio of PEG exhibit higher water absorbance, higher degradation rate in vitro, and lower mechanical strength in the hydrated state. Mouse embryonal carcinoma-derived clonal chondrocytes were used as a model cell type to study the cytocompatibility of the synthesized polymers. Chondrocyte attachment, proliferation rates, and morphologies varied with changes in the PCL/PEG ratio. With a higher PEG ratio, lower cell attachment and proliferation were observed. To improve the cell attachment and proliferation on high PEG content hydrogels, bioactive molecules, such as peptides and proteins, were conjugated or immobilized in the gel matrix during the light-curing process. In this study, a short peptide, Arg-Gly-Asp-Ser, was used as a model biomolecule and incorporated into the gels during the light-curing process and improved cell growth was observed. In summary, the use of PCL/PEG at different ratios, as well as the introduction of HEMA into polyurethane, allows the synthesis of a series of biocompatible elastic hydrogels with tunable physical and cytophilic properties through light-initiated polymerization. This series of materials also allows for controlling cell attachment and growth by incorporating bioactive molecules during the light-curing process.

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Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of biocompatible, degradable, light‐curable, polyurethane‐based elastic hydrogels

Zhang

Wen

2007

J Biomedical Materials Res

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“…An ideal expander should have several characteristics: easily placed through a small access site, gradually enlarge over a relatively short time, well tolerated over the long term, avoid uncomfortable infl ation spikes, and resistant to infection [44] . In 1982, Austad and Rose introduced a self -infl ating expander that consisted of a permeable silicone membrane fi lled with a hypertonic saline solution [45] .…”

Section: Elastic Hydrogels For Tissue Expander Applicationsmentioning

confidence: 99%

Biodegradable Elastic Hydrogels for Tissue Expander Application

Trần

Garner

et al. 2011

Handbook of Biodegradable Polymers

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“…10 The self-filling hydrogel expanders seem to have most of these features. They are small and solid when dehydrated and expand slowly to their final volume, behaving like gelatin when hydrated.…”

Section: Discussionmentioning

confidence: 98%

The use of self-inflating hydrogel expanders in pediatric patients with congenital microphthalmia in China

Hou

Yang

Chen

et al. 2012

Journal of American Association for Pediatric Ophthalmology and

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Use of self-expanding, hydrophilic osmotic expanders (hydrogel) in the reconstruction of congenital clinical anophthalmos

Abstract: Self-expanding hydrogel tissue expanders appear to offer an intriguing reconstructive alternative to the frustrating condition of congenital anophthalmia. Long-term safety of the material as an orbital implant has not yet been demonstrated, but early results are promising.

Cited by 65 publications

References 26 publications

Synthesis and characterization of biocompatible, degradable, light‐curable, polyurethane‐based elastic hydrogels

Synthesis and characterization of biocompatible, degradable, light‐curable, polyurethane‐based elastic hydrogels

Biodegradable Elastic Hydrogels for Tissue Expander Application

The use of self-inflating hydrogel expanders in pediatric patients with congenital microphthalmia in China

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