Use of selenium as micronutrients and for future anticancer drug: a review

Patra, Arup Ranjan; Hajra, Subhadip; Baral, Rathindranath; Bhattacharya, Sudin

doi:10.1007/s13237-019-00306-y

Cited by 18 publications

(10 citation statements)

References 96 publications

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“…Selenium is an essential, naturally occurring trace mineral element, implicated in a diverse set of biological processes that impact health and disease [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Among the three elements (oxygen, sulfur, and selenium) from the chalcogen group of the periodic table that are incorporated into biological macromolecules, both sulfur and Se exhibit similar chemical characteristics in terms of valence states (−2, 0, +2, +4, and +6).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Benefits of Selenium in Hematological Malignancies

Ehudin

Golla

Trivedi

et al. 2022

IJMS

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Supplementing chemotherapy and radiotherapy with selenium has been shown to have benefits against various cancers. This approach has also been shown to alleviate the side effects associated with standard cancer therapies and improve the quality of life in patients. In addition, selenium levels in patients have been correlated with various cancers and have served as a diagnostic marker to track the efficiency of treatments or to determine whether these selenium levels cause or are a result of the disease. This concise review presents a survey of the selenium-based literature, with a focus on hematological malignancies, to demonstrate the significant impact of selenium in different cancers. The anti-cancer mechanisms and signaling pathways regulated by selenium, which impart its efficacious properties, are discussed. An outlook into the relationship between selenium and cancer is highlighted to guide future cancer therapy development.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Benefits of Selenium in Hematological Malignancies

Ehudin

Golla

Trivedi

et al. 2022

IJMS

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“…An investigation carried out by Zhang et al [8] showed that the levels of environmental Se were very low, and Kaschin-Beck disease in the Tibetan Plateau was much severe with decreasing environmental Se under the Se-deficient condition, suggesting the relationship between Kaschin-Beck disease and Se deficiency in the Tibetan Plateau. In addition, Se is related to other human diseases and health, such as cancer [10][11][12][13], muscle disease [14], and healthy aging and longevity [15][16][17]. Therefore, it is essential to maintain Se homeostasis in human body [18,19].…”

Section: Introductionmentioning

confidence: 99%

Selenium Biofortification of Crop Food by Beneficial Microorganisms

et al. 2020

JoF

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Selenium (Se) is essential for human health, however, Se is deficient in soil in many places all around the world, resulting in human diseases, such as notorious Keshan disease and Keshin–Beck disease. Therefore, Se biofortification is a popular approach to improve Se uptake and maintain human health. Beneficial microorganisms, including mycorrhizal and root endophytic fungi, dark septate fungi, and plant growth-promoting rhizobacteria (PGPRs), show multiple functions, especially increased plant nutrition uptake, growth and yield, and resistance to abiotic stresses. Such functions can be used for Se biofortification and increased growth and yield under drought and salt stress. The present review summarizes the use of mycorrhizal fungi and PGPRs in Se biofortification, aiming to improving their practical use.

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“…Due to their high bioavailability and low toxicity, SeNPs are advantageous over their organic and inorganic variants and play a role in biomedical applications, including as anti-oxidants, chemopreventative agents, and anti-cancer drug delivery carriers [ 116 ]. By exploiting the overexpression of folate receptors in most cancers, folate has been widely used as a ligand for nanoparticles.…”

Section: Selenium Nanoparticlesmentioning

confidence: 99%

The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy

Adimulam

Arumugam

Foolchand

et al. 2021

IJMS

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Genetic and epigenetic changes alter gene expression, contributing to cancer. Epigenetic changes in cancer arise from alterations in DNA and histone modifications that lead to tumour suppressor gene silencing and the activation of oncogenes. The acetylation status of histones and non-histone proteins are determined by the histone deacetylases and histone acetyltransferases that control gene transcription. Organoselenium compounds have become promising contenders in cancer therapeutics. Apart from their anti-oxidative effects, several natural and synthetic organoselenium compounds and metabolites act as histone deacetylase inhibitors, which influence the acetylation status of histones and non-histone proteins, altering gene transcription. This review aims to summarise the effect of natural and synthetic organoselenium compounds on histone and non-histone protein acetylation/deacetylation in cancer therapy.

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Use of selenium as micronutrients and for future anticancer drug: a review

Cited by 18 publications

References 96 publications

Therapeutic Benefits of Selenium in Hematological Malignancies

Therapeutic Benefits of Selenium in Hematological Malignancies

Selenium Biofortification of Crop Food by Beneficial Microorganisms

The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy

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