Use of Selective Hemosorption and Hemodiafiltration in a Patient with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury

Masolitin, S. V.; Magomedov, M.A.; Kim, T. G.; Protsenko, D.N.; Smetanina, V. M.; Kalinin, E. Y.

doi:10.21292/2078-5658-2022-19-6-78-85

Vestn. anesteziol. reanimatol.

2022

DOI: 10.21292/2078-5658-2022-19-6-78-85

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Use of Selective Hemosorption and Hemodiafiltration in a Patient with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury

S. V. Masolitin

M.A. Magomedov

T. G. Kim

et al.

Abstract: Российский национальный исследовательский медицинский университет им. Н. И. Пирогова, Москва, РФ Рабдомиолиз (РМ) -клинико-лабораторный синдром, сопровождающийся системным эндотоксикозом вследствие деструкции миоцитов и проявляющийся острым почечным повреждением (ОПП)� Применение экстракорпоральной детоксикации на ранних этапах ОПП в настоящее время не получило признания вследствие отсутствия доказанной эффективности� Цель исследования: демонстрация эффективности применения селективной гемосорбции (СГ) и гемод… Show more

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2024

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Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

Masolitin,

Protsenko,

Tyurin

et al. 2024

Vestn. anesteziol. reanimatol.

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Introduction . The choice of the method and time of initiation of extracorporeal detoxification (ECD) in septic shock (SSh) complicated by acute kidney injury (AKI) is a debatable problem.The objective was to evaluate the influence of various ECD tactics on the dynamics of markers of systemic endotoxicosis and acid-base status (ABS) in patients with SSh complicated by AKI.Materials and methods. Study included 57 patients. Group 1 – 36 patients used continuous veno-venous hemodiafiltration (CVVHDF) for urgent indications. Group 2 – 21 patients used early combined ECD (LPS-sorption and CVVHDF). A comparative analysis of the main laboratory parameters between the groups was performed.Results. Early combined ECD made it possible to reduce the concentration of leukocytes by the 3rd day of therapy from 20.6 to 12.5 ·109/l (39.3 %) from the initial level in group 2, and from 22.2 to 19.15·109/l (13.7 %) in group 1 ( p=0.04); C-reactive protein by the 5th day of therapy from 284 to 145 mg/l (48.9 %) in group 2, and from 299.3 to 199.8 mg/l (33.2 %) in group 1 ( p=0.02); procalcitonin by the 5th day of therapy from 7.2 to 1.6 ng/ml (77.8 %) in group 2, and from 7.8 to 4.45 ng/ml (42.9 %) in group 1 ( p= 0.02); pH by the 3rd day of therapy from 7.17 to 7.37 in group 2, and from 7.19 to 7.27 in group 1 (p =0.04); IL-6 level by the 5th day of therapy from 764.9 to 361.7 pg/ml (52.7 %) in group 2, and from 700.1 to 542.5 pg/ml (22.5 %) in group 1 (p=0.007).Conclusions. Early combined ECD more quickly reduces markers of systemic endotoxicosis and eliminates impairment of ABS, than CVVHDF.

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Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

Masolitin,

Protsenko,

Tyurin

et al. 2024

Vestn. anesteziol. reanimatol.

View full text Add to dashboard Cite

show abstract

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Use of Selective Hemosorption and Hemodiafiltration in a Patient with Toxic Rhabdomyolysis Complicated by Acute Kidney Injury

Cited by 1 publication

References 35 publications

Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

Dynamics of markers of systemic endotoxicosis in patients with gram-negative septic shock during the use of early combined extracorporal detoxification: a prospective multicentric study

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