Use of selected lactic acid bacteria in the eradication of Helicobacter pylori infection

Kim, Jin-Eung; Kim, Min‐Soo; Yoon, Yeo-Sang; Chung, Myung Jun; Yum, Do-Young

doi:10.1007/s12275-014-4355-y

Cited by 28 publications

(13 citation statements)

References 42 publications

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“…Lactococcus and Lactobacillus species are generally thought of as probiotics and considered beneficial to the host. Reports show that lactic acid production has immunomodulative, anti-cancer and anti-inflammatory activities, and is conducive to the eradication therapy of H. pylori (Kim et al, 2014; Han et al, 2015; Kanayama et al, 2018). Another noteworthy taxon enriched in the non-cancer tissues here was S. marcescens , which has not been reported in cancer-related microbiota research before.…”

Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

et al. 2019

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The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific microbiota in the tumor microenvironment is still unclear. Here, mucosa-associated microorganisms from 62 pairs of matched GC tissues and adjacent non-cancerous tissues were characterized by 16S rRNA gene sequencing. Functional profiles of the microbiota were predicted using PICRUSt, and a co-occurrence network was constructed to analyze interactions among gastric microbiota. Results demonstrated that mucosa-associated microbiota from cancerous and non-cancerous tissues established micro-ecological systems that differed in composition, structure, interaction networks, and functions. Microbial richness and diversity were increased in cancerous tissues, with the co-occurrence network exhibiting greater complexity compared with that in non-cancerous tissue. The bacterial taxa enriched in the cancer samples were predominantly represented by oral bacteria (such as Peptostreptococcus , Streptococcus , and Fusobacterium ), while lactic acid-producing bacteria (such as Lactococcus lactis and Lactobacillus brevis ) were more abundant in adjacent non-tumor tissues. Colonization by Helicobacter pylori , which is a GC risk factor, also impacted the structure of the microbiota. Enhanced bacterial purine metabolism, carbohydrate metabolism and denitrification functions were predicted in the cancer associated microbial communities, which was consistent with the increased energy metabolism and concentration of nitrogen-containing compounds in the tumor microenvironment. Furthermore, the microbial co-occurrence networks in cancerous and non-cancerous tissues of GC patients were described for the first time. And differential taxa and functions between the two groups were identified. Changes in the abundance of certain bacterial taxa, especially oral microbiota, may play a role in the maintenance of the local microenvironment, which is associated with the development or progression of GC.

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Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

et al. 2019

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“…A mixture containing L. casei LC5 reduced NO production from the murine RAW264.7 cell line with bacterial lipopolysaccharide, indicating that LC5 involves anti-inflammatory activity (18). Furthermore, B. longum BG7 suppresses H. pylori-induced IL-8 production in human gastric cell lines (19), implying that BG7 can affect cytokine production induced by bacterial infection. Moreover, B. coagulans SANK70258 improves the intestinal environment in healthy adults, as evidenced by an increase in bifidobacteria and a decrease in Clostridium perfringens (17).…”

Section: Discussionmentioning

confidence: 99%

Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study

et al. 2019

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Background: Dietary probiotics supplementation in lactating mothers may help prevent allergic disease in infants. However, owing to a lack of consistency in nutritional and safety outcomes associated with probiotics, this topic remains controversial.Methods: In this open-label pilot trial conducted between April 2013 and December 2013, we evaluated the safety of probiotic supplementation with 5 × 109 CFU of Lactobacillus casei LC5, 5 × 109 CFU of Bifidobacterium longum BG7, and 2 × 108 CFU of Bacillus coagulans SANK70258 in lactating women who exhibited allergies for 2 months (1–3 months postpartum); we also evaluated the effects of probiotic supplementation on transforming growth factor-β (TGF-β) and immunoglobulin A (IgA) levels in human milk. Participants self-selected to join the probiotic (n = 41; age [median (interquartile range [IQR]), y] 33 [27–39], body mass index [BMI] [median (IQR), kg/m2] 21.8 [19.5–22.8]) or no supplementation control group (n = 19; age [median (IQR), y] 33 [23–43], BMI [median (IQR), kg/m2) 19.6 [18.4–22.1]). Probiotics (three tablets) received were taken as daily supplements. Milk samples were collected at 1, 2, and 3 months postpartum, and TGF-β1, TGF-β2, and IgA levels were measured.Results: No adverse effects were observed in the probiotic group, according to the self-recorded diary during the study period. Milk IgA decreased with increasing postpartum months in both groups. In contrast, TGF- β1 and β2 were not affected by lactation periods, and showed different patterns over time between the two groups. TGF-β1, TGF-β1, and IgA levels were significantly correlated at baseline (respectively p < 0.05). However, the correlation between TGF-β1 and IgA became non-significant by the end of the intervention (p = 0.063).Conclusion: Altogether, probiotic supplementation was tolerated with respect to no dropout and 91.5% adherence. Although probiotic supplementation might affect human milk TGF-β levels, a positive effect of probiotic supplementation was not entirely supported. Future placebo-controlled studies are needed to further support the efficacy and safety of probiotic supplementation.Clinical Trial Registration: www.umin.ac.jp/ctr/, identifier: UMIN000036059.

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“…This results in inhibition of the transcription of the inflammatory chemokine genes (120). Numerous other probiotics are extensively used to ameliorate H. pylori-induced complications with the aim to regulate the immune system of the host (162,163).…”

Section: Helicobacter Pylori Infectionmentioning

confidence: 99%

Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation

et al. 2021

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In order to inhibit pathogenic complications and to enhance animal and poultry growth, antibiotics have been extensively used for many years. Antibiotics applications not only affect target pathogens but also intestinal beneficially microbes, inducing long-lasting changes in intestinal microbiota associated with diseases. The application of antibiotics also has many other side effects like, intestinal barrier dysfunction, antibiotics residues in foodstuffs, nephropathy, allergy, bone marrow toxicity, mutagenicity, reproductive disorders, hepatotoxicity carcinogenicity, and antibiotic-resistant bacteria, which greatly compromise the efficacy of antibiotics. Thus, the development of new antibiotics is necessary, while the search for antibiotic alternatives continues. Probiotics are considered the ideal antibiotic substitute; in recent years, probiotic research concerning their application during pathogenic infections in humans, aquaculture, poultry, and livestock industry, with emphasis on modulating the immune system of the host, has been attracting considerable interest. Hence, the adverse effects of antibiotics and remedial effects of probiotics during infectious diseases have become central points of focus among researchers. Probiotics are live microorganisms, and when given in adequate quantities, confer good health effects to the host through different mechanisms. Among them, the regulation of host immune response during pathogenic infections is one of the most important mechanisms. A number of studies have investigated different aspects of probiotics. In this review, we mainly summarize recent discoveries and discuss two important aspects: (1) the application of probiotics during pathogenic infections; and (2) their modulatory effects on the immune response of the host during infectious and non-infectious diseases.

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Use of selected lactic acid bacteria in the eradication of Helicobacter pylori infection

Cited by 28 publications

References 42 publications

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study

Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation

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