Use of scintillation camera and 135Xenon for study of topographic pulmonary function

Newhouse, Michael T.; Wright, F.J.; Ingham, G.K.; Archer, Norm; Hughes, L.B.; Hopkins, O.L.

doi:10.1016/0034-5687(68)90048-0

Cited by 46 publications

(8 citation statements)

References 9 publications

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“…Thus, it was sometimes possible to obtain information about local perfusion from the scan which was not always obtainable from pulmonary angiography. Such detailed information cannot be obtained from 133Xe studies even when batteries of scintillation counters are used, but Newhouse and his co-workers (Newhouse, Wright, Ingham, Archer, Hughes, and Hopkins, 1968) have recently gone some way towards achieving this by quantitating the regional output from a gamma camera using 135Xe.…”

Section: Discussionmentioning

confidence: 99%

Quantitated scintillation scanning for the measurement of lung perfusion

Garnett¹,

Goddard²,

Machell³

et al. 1969

Thorax

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A method using quantitated lung scans is described for the accurate proportioning of lung perfusion. The results obtained by this method have been compared directly with those obtained from bronchospirometry, and a good correlation has been obtained (r = + 0-93).The measurement of lung perfusion by bronchospirometry was first described by Bjorkman in 1934. The method is cumbersome and unpleasant for the patient, since it involves intratracheal intubation. Nevertheless, it is still a standard method for the measurement of individual lung perfusion. In 1964, Wagner, Sabiston, McAfee, Tow, and Stern described their preliminary findings with a new radioisotope lung scanning procedure. They injected macroaggregates of 1311 labelled human serum albumin into a peripheral vein, localized the accumulation of radioactivity in the lung with a Scintiscanner, and postulated that the concentration of radioactively labelled micro-emboli in the various parts of the lung was directly related to pulmonary blood flow.In this study we have compared the blood flow in each lung, as determined by bronchospirometry, with the individual lung perfusion, as determined by a quantitative Scintiscanning procedure. MATERIALS AND METHODSTwenty patients suffering from carcinoma of the bronchus or bullous emphysema were studied.Bronchospirometry was carried out with a double lumen Carlen's catheter connected to Godart Pulmotest spirometers filled with oxygen. The patients were sedated with haloperidol and the catheter was passed under local anaesthesia (one amethocaine lozenge followed by crico-thyroid injection of 10% cocaine and a laryngeal spray with 4% lignocaine).Lung scans were performed using a Picker Magna Scanner V, with a 265 hole, 5 in. focus collimator. Human serum albumin, labelled with approximately 300 juCi 1311, was macroaggregated by heating at its isoelectric point. Scans were made in both the prone and supine positions immediately after injection of the macroaggregates.

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Section: Discussionmentioning

confidence: 99%

Quantitated scintillation scanning for the measurement of lung perfusion

Garnett¹,

Goddard²,

Machell³

et al. 1969

Thorax

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“…A maximum dose of MAA corresponds to ϳ700,000 particles, which occludes Ͻ1 ϫ 10 Ϫ4 % of the pulmonary capillaries (Mallinckrodt Medical, Petten, The Netherlands); according to one manufacturer the particles have a biological half-life of 11 h (Mallinckrodt Medical). With planar gamma camera imaging, regional blood flow has also been studied using intravenous bolus injection of radioactive gases that is allowed to evolve into the alveoli during breathhold (58). The time required for image registration excludes the use of this technique for SPECT.…”

Section: Radiotracers For Imaging Of Regional Blood Flowmentioning

confidence: 99%

“…Later the development of the gamma camera allowed twodimensional imaging of the distribution of radiotracers (58). In the mid to late 1970s, both single-photon-emission computed tomography (SPECT) and positron emission tomography (PET) were developed, offering three-dimensional images of the in vivo distribution of radioactivity.…”

mentioning

confidence: 99%

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

117

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Petersson J, Sá nchez-Crespo A, Larsson SA, Mure M. Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol 102: 468 -476, 2007. First published September 21, 2006; doi:10.1152/japplphysiol.00732.2006.-Emission tomography provides threedimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the imagedegrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be assessed within some percentage of the true value when relevant corrections are applied. SPECT is widely spread, and radiotracers are available that are easy to use and comparably inexpensive. Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. In contrast to some other methods, SPECT allows simultaneous imaging of more than one process, e.g., both regional blood flow and ventilation, for the whole lung. SPECT has been used to explore the influence of posture and clinical interventions on the spatial distribution of lung blood flow and ventilation. Lung blood flow is typically imaged using macroaggregates of albumin. Both radioactive gases and particulate aerosols labeled with radioactivity have been used for imaging of regional ventilation. However, all radiotracers are not equally suited for quantitative measurements; all have specific advantages and limitations. With SPECT, both blood flow and ventilation can be marked with radiotracers that remain fixed in the lung tissue, which allows tracer administration during conditions different from those at image registration. All SPECT methods have specific features that result from the used radiotracer, the manner in which it is administered, and how images are registered and analyzed. respiratory physiology; regional blood flow; pulmonary ventilation; pulmonary gas exchange; radionuclide imaging THE NONUNIFORM DISTRIBUTIONS of regional lung blood flow and ventilation were first demonstrated utilizing radioactive tracers (radiotracers) and external scintillation detectors that registered the distribution of radioactivity within the lung (10,14,43,93). Later the development of the gamma camera allowed twodimensional imaging of the distribution of radiotracers (58). In the mid to late 1970s, both single-photon-emission computed tomography (SPECT) and positron emission tomography (PET) were developed, offering three-dimensional images of the in vivo distribution of radioactivity. These techniques can be used to study, for example, the three-dimensional distribution of regional blood flow or regional ventilation with a high spatial resolution. In this article we will first briefly explain the principles and characteristics of the SPECT method and second review studies that exemplifies how SPECT has been used to increase our unde...

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“…Les valeurs des index dépendent néanmoins du volume, du niveau et du débit ventilatoires ce qui oblige de pratiquer les examens d'une manière rigou reusement standardisée, et d'établir des valeurs normales pour chaque technique employée. Les index obtenus avec notre méthode étaient com parables à ceux de la littérature [3,7,15]. Par ailleurs, il faut reconnaître les limites de l'emploi des index.…”

Section: Discussionunclassified