Abstract:At present, in epilepsy, magnetoencephalography (MEG) is mostly used for presurgical evaluations. It has proven to be robust for detecting and localizing interictal epileptiform discharges. Whether this is also true for first-line investigation in the diagnosis of epilepsy has not been investigated yet. We present our data on the usefulness of MEG in the earliest phase of diagnosing epilepsy. We examined 51 patients with suspicion of neocortical epilepsy and an inconclusive routine EEG. A method to integrate M… Show more
“…MEG results correlate well with intracranial EEG recordings and have improved localization of ictal onset. The accuracy of MEG for predicting surgical outcome is thought to be secondary only to intracranial subdural EEG monitoring, and failure to remove regions with MEG dipoles predicts postoperative seizure recurrence [7]. MEG is increasingly utilized as a noninvasive method for seizure localization and for preoperative planning of resections.…”
“…MEG results correlate well with intracranial EEG recordings and have improved localization of ictal onset. The accuracy of MEG for predicting surgical outcome is thought to be secondary only to intracranial subdural EEG monitoring, and failure to remove regions with MEG dipoles predicts postoperative seizure recurrence [7]. MEG is increasingly utilized as a noninvasive method for seizure localization and for preoperative planning of resections.…”
“…Therefore, while in a limited number of cases an unequivocal diagnosis can be made, there is no gold standard proving that a person does not have epilepsy. Decades after the first description of the occipital alpha, rhythm producing a detectable magnetic field magnetoencephalography (MEG) is also gaining ground, both in the primary diagnosis of epilepsy and in the presurgical evaluation of patients with drug‐resistant epilepsy .…”
“…Magnetoencephalography (MEG) reflecting the state of electrical activity within the neurons offers better accuracy in localizing the focus of epileptogenic activity compared to EEG due to the elimination of artifacts from the surrounding tissues and high temporal resolution. It is used in some centres for presurgical evaluation and was found to be an important diagnostic modality in “inconclusive” cases [17]. Positron emission tomography (PET) [18] scanning has been transformed from a confirmatory tool of assessing aberrations in glucose metabolism to a rather precise instrument of specific ligands tracing/uptake, assisting in localizing and understanding the neurochemical basis of CNS pathology.…”
Temporal lobe epilepsy (TLE), a subset of the seizure disorder family, represents a complex neuropsychiatric illness, where the neurological presentation may be complemented by varying severity of affective, behavioral, psychotic, or personality abnormalities, which, in turn, may not only lead to misdiagnosis, but also affect the management. This paper outlines a spectrum of mental health presentations, including psychosis, mood, anxiety, panic, and dissociative states, associated with epilepsy that make the correct diagnosis a challenge.
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