Use of rituximab in NHL malt type pregnant in I° trimester for two times

Sica, Antonello; Vitiello, Paola; Papa, Alfonso; Calogero, Armando; Sagnelli, Caterina; Casale, Danilo; Mottola, Maria; Svanera, Gino; Dodaro, Concetta Anna; Martinelli, Erika; Troiani, Teresa; Ciardiello, Fortunato; Casale, Beniamino

doi:10.1515/med-2019-0087

Cited by 28 publications

(20 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One month later, fluorescence in-situ hybridization (FISH) was performed to assess the mutational status of BCL2, BCL6 and MYC genes and showed no genetic rearrangements. Based on clinical and instrumental findings, Stage IE was assigned according to the Ann Arbor staging Lamivudine prophylaxis was administered 4 weeks before chemotherapy according to current guidelines [10][11][12][13].…”

Section: Case Reportmentioning

confidence: 99%

Primary cutaneous DLBCL non-GCB type: challenges of a rare case

et al. 2020

Self Cite

View full text Add to dashboard Cite

AbstractSeveral types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin.

show abstract

Section: Case Reportmentioning

confidence: 99%

Primary cutaneous DLBCL non-GCB type: challenges of a rare case

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The CLL associated with del(11q) or del (17p) among clinical forms with the worst prognosis [3]. Clinical studies have shown that Ibrutinib has been used to treat the clinical form associated with the mutation del(17p), a more favorable response than that obtained with a conventional chemotherapy (rituximab, cyclophosphamide, fludarabine) [4]. This is the first clinical report of an 80-year-old patient with CLL related to del(11q), who presented voluminous solid tissue in the abdominal cavity (23 × 14 × 4 cm) which occupied the whole of the mesentery and the retroperitoneal space by displacing the pancreas anteriorly and the intestinal loops laterally, which prevented adequate nutrition.…”

Section: Introductionmentioning

confidence: 99%

An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program

Sica

Sagnelli

Papa

et al. 2020

IJERPH

Self Cite

View full text Add to dashboard Cite

Chronic lymphatic leukemia (CLL) is the most frequent type of leukemia in western countries and when association with del(11q) is correlated with a worse prognosis. We reported the clinical case of an 80-year-old patient with CLL related to del(11q) and a BMI of 16.4 kg/m2, who presented a voluminous mass in abdominal cavity (23 × 14 × 4 cm) which occupied the whole of the mesentery and the retroperitoneal space, treated with ibrutinib, adequate nutrition, and a program of physical activity. He showed a great improvement under ibrutinib therapy and took to artificial nourishment and adequate muscle rehabilitation until he recovered his autonomy. In August 2018, a 5-days-a-week training program was started: Physical activity for at least 20 min consisting of a fast walk in the open air three times a week and a moderate physical activity in the remaining two days of at least 20 consecutive minutes (cycling at a regular pace, carrying light weights). The exercise program included also aerobic, upper and lower limb resistance training, chore stability and stretches. The physical condition further improved and remained excellent throughout the follow-up period. In December 2018, his clinical condition was quite normal; a CT showed a great decrease of all lymphoadenomegaly, and FISH test did not show del(11q). He continued to cultivate his land, while still being treated with ibrutinib. The combination of the right therapy, adequate nutrition, and muscle rehabilitation is the best solution to improve the clinical condition of old cachectic CLL del(11q) patient.

show abstract

“…Especially in lymphomas, but also in other neoplasms, the mechanisms involving these cells are altered, helping to not amplify neuropathic pain [16][17][18][19][20]. It is evident that the complexity of the pathogenesis of neuropathic pain does not allow unambiguous solutions in these patients who should be mobilized immediately after surgical In our study 51 elderly patients who had undergone a transthoracic biopsy to verify one suspect of mediastinal lymphoma were examined for pain reduction with oral opioids, effect of epidural analgesia and paravertebral block [33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Sica¹,

Casale²,

Sagnelli³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Thoracotomy is one of the most painful types of incision a patient can experience. Pain is a very complex pathophysiological entity. Neuronal pathophysiological mechanisms are integrated with the immunological response, which amplify inflammation and pain. Prolonged inflammation induces a pathological response of the immune-system and constantly stimulate the nociceptive pathways generating chronic pain. The mechanisms are particularly altered in lymphomas, where pain following chest surgery often becomes chronic and reduces the quality of life. In this study 51 elderly patients who had undergone a transthoracic biopsy to verify the suspect of mediastinal lymphoma were examined for pain reduction with oral opioids, effect of epidural analgesia and paravertebral block. Subsequently, patients underwent tensed torsion exercises, progressively intensified. After the first few days, patients walked progressively for 20 minutes a day. Once discharged a program of patients started aerobic exercises to increase muscle endurance and to strengthen the extensor muscles of the legs and of the upper limbs. The systemic administration of opioids is the simplest and most common method of providing analgesia for postoperative pain, but early mobilization, respiratory rehabilitation, and muscle toning exercises are excellent support devices both for physical and psychological recovery.

show abstract

Use of rituximab in NHL malt type pregnant in I° trimester for two times

Cited by 28 publications

References 11 publications

Primary cutaneous DLBCL non-GCB type: challenges of a rare case

Primary cutaneous DLBCL non-GCB type: challenges of a rare case

An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Contact Info

Product

Resources

About