Use of Redness Assessment in Melasma Lesions in Skin Whitening Evaluation

Lee, Jung Ah; Yoon, Jung Hwan; Lee, Sun Hwa; Kim, Bora; Kim, Nam Soo; Moon, Todd K.

doi:10.15230/scsk.2016.42.4.337

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…7,8 Therefore, interest in skin whitening is continuously increasing, not only in terms of skin health but also in terms of beauty, and research on the development of skin whitening agents is being actively pursued. 9 Accordingly, there is demand for a safe cosmetic composition for skin whitening. In addition, because of the nature of cosmetics used directly on the skin, the skin permeability must be excellent.…”

Section: Introductionmentioning

confidence: 99%

Ligularia fischeri ethanol extract: An inhibitor of alpha‐melanocyte‐stimulating hormone‐stimulated melanogenesis in B16F10 melanoma cells

Lim

Joo

Choi

et al. 2022

J of Cosmetic Dermatology

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Background: Ligularia fischeri is a perennial herb isolated from plants of the Asteraceae family. Ligularia fischeri is distributed throughout Korea, Japan, eastern Siberia, and China. Aims:The aim of this study is to examine the intracellular inhibitory effect of Ligularia fischeri ethanol extract on melanin synthesis and expression of tyrosinase and tyrosinase-related protein 1 and 2. In addition, we analyzed the mitogen-activated protein kinase signaling pathway and microphthalmia-associated transcription factor in alpha-melanocyte-stimulating hormone-stimulated B16F10 melanoma cells. Methods:To assess the inhibition of melanogenesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 melanoma cells, the expression of melanogenesisrelated genes was investigated by quantitative real-time polymerase chain reaction, while western blotting was performed to determine protein expression levels. Results:We confirmed that the ethanol extract of Ligularia fischeri inhibited melanin synthesis in vitro by decreasing tyrosinase and tyrosinase-related protein 1 and 2 expression. Furthermore, we revealed that tyrosinase expression was regulated by the suppression of microphthalmia-associated transcription factor expression and activation of extracellular signal-regulated kinase phosphorylation. The ethanol extract of Ligularia fischeri inhibited melanogenesis by activating extracellular signal-regulated kinase phosphorylation and suppressing microphthalmia-associated transcription factor and tyrosinase expression.Conclusions: Ligularia fischeri ethanol extract may be used as an effective skin whitening agent in functional cosmetics.

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Section: Introductionmentioning

confidence: 99%