Use of Recombinant Growth Factors after Hematopoietic Cell Transplantation

Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning

“…In the mouse that lost weight, necropsy revealed splenomegaly ( Figure S2C ), possibly reflecting extramedullary hematopoiesis due to cytopenia from delayed bone marrow function. If so, this could be treated in the future with prophylactic HSC growth factors, like in the clinic ( Finke and Mertelsmann, 2015 ). We also observed transient loss of hair pigmentation in a subset of mice ( Figure S2D ), possibly reflecting CD117 function in hair follicle melanocytes or pigmentation loss from TBI ( Aoki et al, 2011 , 2013 ; Czechowicz et al, 2007 ).…”