Use of Radiotherapy for Control of Sialorrhea in Patients with Amyotrophic Lateral Sclerosis

Harriman, Maureen; Morrison, Murray; Hay, John; Revonta, Matti; Eisen, Andrew; Lentle, Brian C.

doi:10.2310/7070.2001.19779

Cited by 51 publications

(40 citation statements)

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“…15 A "satisfactory response" was observed and saliva secretion rate diminished with a single dose of 7-7.5 Gy bilaterally (Class III). 16 Conclusions.…”

Section: What Are the Most Effective Treatments For Sialorrhea?mentioning

confidence: 94%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Miller¹,

Jackson²,

Kasarskis³

et al. 2009

Neurology

561

417

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Objective: To systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS). Methods:The authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking the news, multidisciplinary clinics, symptom management, cognitive and behavioral impairment, communication, and palliative care for patients with ALS.

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“…15 A "satisfactory response" was observed and saliva secretion rate diminished with a single dose of 7-7.5 Gy bilaterally (Class III). 16 Conclusions.…”

Section: What Are the Most Effective Treatments For Sialorrhea?mentioning

confidence: 94%

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Miller¹,

Jackson²,

Kasarskis³

et al. 2009

Neurology

561

417

View full text Add to dashboard Cite

show abstract

“…Toxicity of treatment was generally reported to be minimal. At the time of irradiation, commonly reported adverse effects included mild pain [8,10,11,13], erythema [13], and mucositis [11]. Long term side effects, including xerostomia [8,9,11,12] and thickened salivary secretions [9,10], were more commonly reported.…”

Section: Discussionmentioning

confidence: 99%

Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

Slade

Stanic

2015

Journal of the Neurological Sciences

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“…It has been suggested that a dose of 8 Gy delivered in a single fraction may be as effective and safe as higher fractionated doses, 14 and increasing the dose did not improve initial achievement. 61 A review of published studies on BoNT and radiotherapy for sialorrhea in ALS attempted to evaluate and compare the effectiveness and side effects of the 2 treatments. However, because of the small number of published studies, the small sample sizes, and the poor quality of reporting, it was not possible to draw firm conclusions recommending one treatment over the other.…”

Section: Wkmentioning

confidence: 99%

A Review of Options for Treating Sialorrhea in Amyotrophic Lateral Sclerosis

et al. 2014

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Sialorrhea or drooling represents quite a common problem in patients with amyotrophic lateral sclerosis (ALS). In this review, we describe the possible treatments for this issue. Current medical management is not always effective: anticholinergic drugs (atropine, glycopyrrolate, amitriptyline, hyoscyamine, and transdermal scopolamine) are often used, but there is very little evidence of their effectiveness in patients with ALS. More invasive treatments, such as botulinum toxin injections and/or radiation therapy in the salivary glands, can be considered when anticholinergic drugs are not effective. In this review, we also explore the possible surgical options for treatment of sialorrhea. Although no specific studies have been conducted on patients with ALS, surgical therapies might represent a valid option for treatment of sialorrhea since there is no tachyphylaxis or need for repeated therapeutic sessions.

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Use of Radiotherapy for Control of Sialorrhea in Patients with Amyotrophic Lateral Sclerosis

Cited by 51 publications

References 0 publications

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review)

Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

A Review of Options for Treating Sialorrhea in Amyotrophic Lateral Sclerosis

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