Use of Race and Ethnicity in Biomedical Publication

Kaplan, Judith B.; Bennett, Trevor

doi:10.1001/jama.289.20.2709

Cited by 510 publications

(513 citation statements)

References 83 publications

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“…22 Clearly, inter-racial and ethnic differences in polymorphisms of genes may exist, affecting susceptibility to diverse diseases. 23 Common, complex diseases show an unknown mode of inheritance, and differing ethnicity, along with other factors, could confound the pathogenesis of CAD. We speculate that our positive results may be partly owing to the finding that 82S allele frequencies of the RAGE gene are statistically higher in the Chinese Han population compared with other countries and ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population

et al. 2010

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The role of an advanced glycation end product/receptor for advanced glycation end product (AGE/RAGE) system in the pathogenesis of coronary artery disease (CAD) is not fully understood. To clarify whether polymorphisms of the RAGE gene were related to CAD, we performed a case-control study in Chinese Han patients. The allele frequencies and genotype distribution combinations of the À429T/C, 1704G/T and G82S polymorphisms of the RAGE gene were compared in 200 cases of hypertension (HT), 155 cases of CAD combined with HT (CAD&HT), 175 cases of CAD and 170 control subjects. Polymerase chain reaction-restriction fragment length polymorphism was used for detection of genotypic variants. The S allele frequency of the G82S polymorphism was higher in the CAD (odds ratio (OR), 2.303, 95% confidence interval (CI) 1.553-3.416; Po0.001, P corr o0.003) and CAD&HT (OR, 1.842; 95% CI 1.219-2.785; Po0.003, P corr o0.009) groups when compared with the control group. However, the S allele frequency was not significantly different between the CAD and the CAD&HT patient groups (P¼0.223), and no statistically significant difference of genotype or allele frequency distributions was observed in the HT group (P40.05). Meanwhile, serum CRP was significantly associated with the G82S variant. Haplotype-based logistic regression analysis revealed that haplotype G-Ser-T (OR, 1.670; 95% CI, 1.017-2.740; P¼0.043), compared with the reference haplotype T-Gly-T, was associated with an increased risk of CAD after adjusting for other risk factors. Further analysis limited to nondiabetic participants exhibited similar significant findings. The haplotype carrying the G82S variant of the RAGE gene was significantly associated with an increased risk of CAD, but not with HT patients. Moreover, a remarkable association of the G82S variant with serum CRP levels implied that the prevalence of RAGE 82S allelic variation might influence susceptibility to CAD by affecting vascular inflammation.

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Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population

et al. 2010

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“…En la literatura ya se ha indicado la necesidad de explicitar y justificar la práctica de cómo asignar la denominación étnica o racial de los participantes en los estudios (Kaplan y Bennett, 2003). Se han evaluado además las limitantes y ventajas de su uso en el marco de las hipótesis o propósitos de las investigaciones (Aspinall, 2001).…”

Section: Discusión Y Conclusionesunclassified

“…De hecho, se espera continuar esta línea de trabajo con una investigación sobre lo que dicen (conceptualizaciones y significados) y hacen los investigadores (mecanismos usados para "etiquetar" a las poblaciones) sobre la relación entre la etnoracialidad y la salud pública; estos estudios contribuirían a rastrear las influencias de las formaciones raciales en las investigaciones en salud en Colombia y, en últimas, "a encontrar la manera menos imprecisa para aproximarse, con fines descriptivos y estadísticos, a los conceptos sociales de raza y etnicidad" (Kaplan y Bennett, 2003:2711.…”

Section: Discusión Y Conclusionesunclassified

Unveiling what is said in the colombian public health journals about race and ethnicity

Mosquera-Becerra

2015

Rev.CS

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Unveiling what is said in the colombian public health journals about race and ethnicity Revelando o que dizem sobre raça e etnia as revistas de saúde pública da ColômbiaEste artículo analiza cómo en investigaciones publicadas (período 1994-2011) en las tres principales revistas de salud pública de Colombia se conceptualiza, nomina e interpreta la categoría étnico-racial en relación a la población afrodescendiente en el país. Se identificó que es limitado el número de artículos publicados que abordan las nociones de raza o etnia; además, estas se usan de manera intercambiable, y no se conceptualiza ni se explícita el por qué ni cómo se recolectan estas categorías. Bajo la existencia de un racismo estructural, la inclusión de la dimensión etno-racial en las investigaciones de salud, contribuiría a identificar procesos y dinámicas que crean y recrean iniquidades etno-raciales en salud. PALABRAS CLAVE:Raza | etnia | salud | salud pública Resumen AbstractThis article analyzes how in published studies (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011) in the three main public health journals of Colombia are conceptualized, operationalized and interpreted racial and ethnic categories in relation to the black population. It was identified that are limited the number of published articles that address race or ethnicity; in addition, those notions are used interchangeably, and; it is not showed how is conceptualized and collected those social categories. Under the existence of structural racism, including ethno-racial categories in health research could help to identify processes and dynamics that create and recreate health disparities based on race and ethnicity. KEYWORDS:Race | ethnicity | health | public health ResumoEste artigo analisa como em pesquisas publicadas (período 1994-2011) nas três principais revistas de saúde pública da Colômbia se conceitua, nomina e interpreta a categoria ét-nico-racial em relação à população afrodescendente no país. Foi possível identificar que é limitado o número de artigos publicados que abordam as noções de raça ou etnia; além do mais, estas se usam de maneira intercambiável, e não se conceitua nem se explicita o porquê, nem como se coletam estas categorias. Sob a existência de um racismo estrutural, a inclusão da dimensão étnico-racial nas pesquisas de saúde, contribuiria para a identificação de processos e dinâmicas que criam e recriam iniquidades étnico-raciais em saúde. PALAVRAS -CHAVE:Raça | etnia | saúde | saúde pública

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“…60 Genetic differences are greater within socially defined racial groups than between groups. 61 Additionally, it has been found that genetic diversity decreases in noncoding regions whereas diversity of coding nonsynonymous SNPs is lower in regions containing a known protein sequence motif in individuals of European origin. 62 Drug treatment may be tailored for greater effect if important genetic variation exists between racial and ethnic groups.…”

Section: Ethnicitymentioning

confidence: 99%