Use of quinolones in childhood

Cruciani, Mario; Perri, Giovanni Di; Concia, Ercole; Bassetti, Dante; Navarra, A.

doi:10.1016/s0022-3476(89)80765-6

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…Incidentally, this line of work is confluent with the interests shown recently in the particle physics community [8,183,190,201,212] for head-on collisions and the associated radiation reaction [89,90]. Hopefully, progress in numerical relativity may lead to analysis of larger mass ratios and thereby test future results of perturbation theory 40 in the range beyond 10 −3 .…”

Section: Discussionmentioning

confidence: 94%

“…The particle plunges on a geodesic trajectory, incidentally starting from a circular orbit, thus at zero initial radial velocity. 40 For head-on collisions, Price and Pullin have surprisingly shown the applicability of perturbation theory for the computation of the radiated energy and of the waveform for two equal black holes, starting at very small separation distances [163], the so called close-limit approximation.…”

Section: Discussionmentioning

confidence: 99%

“…16 A well organised introduction, largely based on works by Friedman [83] and Chandrasekhar [32], is presented in the already mentioned book by the latter [33]. Some selected publications geared to the finalities of this chapter are to be listed: earlier works by Mathews [138], Stachel [193], Vishveshvara [202]; the relation between odd and parity perturbations [34]; the search for a gauge invariant formalism by Martel and Poisson [140] complements a recent review on gauge invariant non-spherical metric perturbations of the SD black hole spacetimes by Nagar and Rezzolla [153]; a classic reference on multiple expansion of gravitational radiation by Thorne [198]; the derivation by computer algebra by Cruciani [40,41] of the wave equation governing black hole perturbations; the numerical hyperboloidal approach by Zenginonglu [215]. in this way, the problem of the linearised theory on flat spacetime (for which the particle moves on a geodesic of flat space which determines uniform motion and thereby without emission of radiation) is avoided.…”

Section: Black Hole Perturbationsmentioning

confidence: 99%

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Free Fall and Self-Force: an Historical Perspective

Spallicci

2009

Mass and Motion in General Relativity

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Free fall has signed the greatest markings in the history of physics through the leaning Pisa tower, the Cambridge apple tree and the Einstein lift. The perspectives offered by the capture of stars by supermassive black holes are to be cherished, because the study of the motion of falling stars will constitute a giant step forward in the understanding of gravitation in the regime of strong field. After an account on the perception of free fall in ancient times and on the behaviour of a gravitating mass in Newtonian physics, this chapter deals with last century debate on the repulsion for a Schwarzschild black hole and mentions the issue of an infalling particle velocity at the horizon. Further, black hole perturbations and numerical methods are presented, paving the way to the introduction of the self-force and other back-action related methods. The impact of the perturbations on the motion of the falling particle is computed via the tail, the back-scattered part of the perturbations, or via a radiative Green function. In the former approach, the self-force acts upon the background geodesic; in the latter, the geodesic is conceived in the total (background plus perturbations) field. Regularisation techniques (mode-sum and Riemann-Hurwitz z function) intervene to cancel divergencies coming from the infinitesimal size of the particle. An account is given on the state of the art, including the last results obtained in this most classical problem, together with a perspective encompassing future space gravitational wave interferometry and head-on particle physics experiments. As free fall is patently non-adiabatic, it requires the most sophisticated techniques for studying the evolution of the motion. In this scenario, the potential of the self-consistent approach, by means of which the background geodesic is continuously corrected by the self-force contribution, is examined.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Black Hole Perturbationsmentioning

confidence: 99%

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Free Fall and Self-Force: an Historical Perspective

Spallicci

2009

Mass and Motion in General Relativity

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Antibiotics in intensive care unit patients

Lalla¹,

Cruciani²

1998

Critical Care Nephrology

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Sicherheit und Wirksamkeit von Ciprofloxacin bei pädiatrischen Patienten — Eine Durchsicht der Literatur

Kubin

1993

Infection

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Like all fluoroquinolones, ciprofloxacin causes articular damage in juvenile animals. Consequently, this drug was not recommended for children or pregnant women. However, due to its antibacterial effectiveness and convenience of oral administration, ciprofloxacin is now increasingly used for the treatment of certain infectious conditions in children and adolescents aged less than 18 years. In this paper the published literature on this subject is reviewed. Up to now, data are available on more than 1,500 paediatric patients who were given ciprofloxacin, two-thirds of whom were suffering from acute infectious bronchopulmonary exacerbations of cystic fibrosis, mainly due to Pseudomonas aeruginosa. The effectiveness of oral ciprofloxacin for this indication compared well to that of standard intravenous combination regimens. The majority of the remaining published trials was conducted in children with multiresistant typhoid fever; the administration of ciprofloxacin was successful in up to 100% of the cases. The safety profile of ciprofloxacin in children and adolescents was very similar to that observed in adult patients. Adverse events were noted in 5-15%, with gastrointestinal, skin and central nervous system reactions being the most common. Reversible arthralgia occurred in 36 out of 1,113 patients with cystic fibrosis, and in no case could cartilage damage be demonstrated by radiographic procedures. Thus, publication data clearly suggest that the administration of ciprofloxacin to children is effective and safe, but there is a need for further prospective, well-controlled clinical trials.

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Use of quinolones in childhood

Cited by 6 publications

References 4 publications

Free Fall and Self-Force: an Historical Perspective

Free Fall and Self-Force: an Historical Perspective

Antibiotics in intensive care unit patients

Sicherheit und Wirksamkeit von Ciprofloxacin bei pädiatrischen Patienten — Eine Durchsicht der Literatur

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