Use of Psychotropic Drugs and Alcohol among Non-Institutionalised Elderly Adults in Germany

Du, Yong; Scheidt‐Nave, Christa; Knopf, Hildtraud

doi:10.1055/s-0028-1083791

Cited by 28 publications

(63 citation statements)

References 42 publications

(73 reference statements)

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“…Of the 546 citations identified from this search strategy, 108 full text articles were assessed for eligibility, with 20 studies meeting the inclusion criteria [14, 18–36] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…Ten of the included studies were conducted in Europe [14, 19, 21–23, 25, 27–29, 36], eight in North America [18, 20, 24, 30–32, 34, 35] and two in Australia [26, 33]. (Table 1) All studies were cross-sectional [14, 18–36].…”

Section: Resultsmentioning

confidence: 99%

“…(Table 1) All studies were cross-sectional [14, 18–36]. Study settings varied across studies with; community-dwelling [14, 19, 21–27, 31, 34–36], both community dwelling or living independently in care facilities [32], general populations [20, 28, 33], hospital setting [29], retirement communities [18] and participants signed up to a pharmaceutical assistance contract for the elderly [30] reported.…”

Section: Resultsmentioning

confidence: 99%

“…For example, older adults are vulnerable to the sedating effects of alcohol and when combined with central nervous system (CNS) agents, such as psychotropic medications, older adults have an increased risk of sedation and drowsiness [5]. Psychotropic medicines include antidepressants, sedatives/hypnotics, stimulants and neuroleptics, all of which act on the CNS and are commonly prescribed to older adults [14]. Similarly, concurrent use of alcohol with cardiovascular agents, such as vasodilatory agents, increases the risk of hypotension in older adults [5], with concurrent use with non-steroidal anti-inflammatory drugs (NSAIDs) increasing the risk of gastrointestinal bleeds [12].…”

Section: Introductionmentioning

confidence: 99%

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Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes

et al. 2017

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BackgroundOlder adults are susceptible to adverse effects from the concurrent use of medications and alcohol. The aim of this study was to systematically review the prevalence of concurrent use of alcohol and alcohol-interactive (AI) medicines in older adults and associated adverse outcomes.MethodsA systematic search was performed using MEDLINE (PubMed), Embase, Scopus and Web of Science (January 1990 to June 2016), and hand searching references of retrieved articles. Observational studies reporting on the concurrent use of alcohol and AI medicines in the same or overlapping recall periods in older adults were included. Two independent reviewers verified that studies met the inclusion criteria, critically appraised included studies and extracted relevant data. A narrative synthesis is provided.ResultsTwenty studies, all cross-sectional, were included. Nine studies classified a wide range of medicines as AI using different medication compendia, thus resulting in heterogeneity across studies. Three studies investigated any medication use and eight focused on psychotropic medications. Based on the quality assessment of included studies, the most reliable estimate of concurrent use in older adults ranges between 21 and 35%. The most reliable estimate of concurrent use of psychotropic medications and alcohol ranges between 7.4 and 7.75%. No study examined longitudinal associations with adverse outcomes. Three cross-sectional studies reported on falls with mixed findings, while one study reported on the association between moderate alcohol consumption and adverse drug reactions at hospital admission.ConclusionsWhile there appears to be a high propensity for alcohol-medication interactions in older adults, there is a lack of consensus regarding what constitutes an AI medication. An explicit list of AI medications needs to be derived and validated prospectively to quantify the magnitude of risk posed by the concurrent use of alcohol for adverse outcomes in older adults. This will allow for risk stratification of older adults at the point of prescribing, and prioritise alcohol screening and brief alcohol interventions in high-risk groups.Electronic supplementary materialThe online version of this article (doi:10.1186/s12877-017-0532-2) contains supplementary material, which is available to authorized users.

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“…Of the 546 citations identified from this search strategy, 108 full text articles were assessed for eligibility, with 20 studies meeting the inclusion criteria [14, 18–36] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Concurrent use of alcohol interactive medications and alcohol in older adults: a systematic review of prevalence and associated adverse outcomes

et al. 2017

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“…Older persons are likely to suffer from one or more diseases, age-related functional impairments, systemic changes of the immune system, the endocrine system, and the ability to maintain salt and water balance as well as an increase in the use of psychotropic drugs [6,7,8,9,10]. Not surprisingly, an increasing number of coexisting health conditions among older persons is associated with disability, poorer health outcomes and quality of life, and higher health care utilization [2,5,11,12].…”

Section: Introductionmentioning

confidence: 99%