Use of proton pump inhibitors and mortality among Icelandic patients with prostate cancer

Hálfdánarson, Óskar; Pottegård, Anton; Lund, Sigrún H.; Ögmundsdóttir, Margrét H.; Ögmundsdóttir, Helga M.; Zoëga, Helga

doi:10.1111/bcpt.13379

Cited by 4 publications

(1 citation statement)

References 38 publications

(42 reference statements)

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“…The same was perceived when PPIs were synergistically administered with raloxifene to T47D cells ( 103 ), another breast cancer cell line, suppressing cell growth compared to the raloxifene alone. PPI administration was also evaluated in Prostate cancer patients, yet no significant results indicated their effectiveness as a cancer drug ( 104 ). HKA (coded by ATP4A, ATP4B and ATP12A) is expressed in pancreatic ducts and is responsible for regulating the secretion of pancreatic fluid but is also expressed in pancreatic cancer cells.…”

Section: Hkamentioning

confidence: 99%

Clinical significance of P‑class pumps in cancer (Review)

et al. 2021

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P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic cells. The present review aimed to evaluate the role of P-type pumps [Na + /K + ATPase (NKA), H + /K + ATPase (HKA) and Ca2 + -ATPase] in cancer cells across three fronts, namely structure, function and genetic expression. It has been shown that administration of specific P-class pumps inhibitors can have different effects by: i) Altering pump function; ii) inhibiting cell proliferation; iii) inducing apoptosis; iv) modifying metabolic pathways; and v) induce sensitivity to chemotherapy and lead to antitumor effects. For example, the NKA β2 subunit can be downregulated by gemcitabine, resulting in increased apoptosis of cancer cells. The sarcoendoplasmic reticulum calcium ATPase can be inhibited by thapsigargin resulting in decreased prostate tumor volume, whereas the HKA α subunit can be affected by proton pump inhibitors in gastric cancer cell lines, inducing apoptosis. In conclusion, the present review highlighted the central role of P-class pumps and their possible use and role as anticancer cellular targets for novel therapeutic chemical agents.

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Section: Hkamentioning

confidence: 99%