Use of proteomics in the study of microbial diseases of small ruminants

Katsafadou, Angeliki I.; Tsangaris, George Th.; Billinis, Charalambos; Fthenakis, George C.

doi:10.1016/j.vetmic.2015.07.017

Cited by 8 publications

(5 citation statements)

References 90 publications

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“…These biomarkers were α-2 macroglobulin, α-1 antitrypsin, haptoglobin, Serum Amyloid A3, cluster of differentiation CD14, calgranulin B, calgranulin C, cathepsin C, vanin-1, galectin-1, galectin-3 and interleukin 8. This field is growing all the time and it is likely that in the future it will extend to other species such as small ruminants (Katsafadou et al ., 2015; Hernández-Castellano et al ., 2016 a , 2016 b ; Vasileiou et al ., 2019) and water buffalo (Patbandha et al ., 2015). Different biomarkers may be more applicable in non-bovine species, for instance, cathelicidin has been proposed for use in goats (Tedde et al ., 2019).…”

Section: Consequences and Applicationsmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Zachut

Šperanda

Almeida

et al. 2020

Journal of Dairy Research

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Milk production intensification has led to several unwanted aspects, such as sustainability issues and environmental pollution. Among these, increased milk outputs that have been achieved over the last 70 years have led to several health and pathophysiological conditions in high yielding dairy animals, including metabolic diseases that were uncommon in the past. Increased occurrence of diverse metabolic diseases in cattle and other domestic animals is a key feature of domestication that not only affects the animals' health and productivity, but also may have important and adverse health impacts on human consumers through the elevated use of drugs and antibiotics. These aspects will influence economical and ethical aspects in the near future. Therefore, finding and establishing proper biomarkers for early detection of metabolic diseases is of great interest. In the present review, recent work on the discovery of fitness, stress and welfare biomarkers in dairy cows is presented, focusing in particular on possible biomarkers of energy balance and oxidative stress in plasma and milk, and biomarkers of production-related diseases and decreased fertility.

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Section: Consequences and Applicationsmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Zachut

Šperanda

Almeida

et al. 2020

Journal of Dairy Research

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“…the Polymerase Chain Reaction (PCR) or Matrix-Assisted Laser Desorption/Ionisation-Time of Flight (MALDI-TOF). The latter analyses the protein profile of bacterial cells (Katsafadou et al ., 2015).…”

Section: The Microorganismmentioning

confidence: 99%

Role of staphylococci in mastitis in sheep

Vasileiou

Chatzopoulos

Sarrou

et al. 2019

Journal of Dairy Research

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Staphylococci have been isolated from various sites of the body of healthy sheep, as well as from many infections of those animals, the main one being mastitis. The objective of this review is to appraise the importance and significance of staphylococci in causing mastitis in ewes. The review includes a brief classification and taxonomy of staphylococci and describes the procedures for their isolation and identification, as well as their virulence determinants and the mechanisms of resistance to antibacterial agents. Various staphylococcal species have been implicated in staphylococcal mastitis and the characteristics of isolates are discussed with regards to potential virulence factors. Staphylococcal mastitis is explicitly described, with reference to sources of infection, the course of the disease and the relevant control measures. Finally, the potential significance of staphylococci present in ewes’ milk for public health is discussed briefly.

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“…In healthy mammary glands, the complement system is activated only through the alternative complement pathway; the classical pathway is not functional, as C1q component is absent or present in smaller concentrations than in blood [95]. During inflammation, complement dependent bactericidal and opsonic activities increase in blood [28,99] (Figure S5). Pathogens opsonised by IgG or complement have increased affinity to phagocytose Fc or complement C3b receptors, respectively, promoting phagocyte–bacteria attachment and bacterial phagocytosis.…”

Section: Immunoglobulins and Complement Systemmentioning

confidence: 99%

Mammary Defences and Immunity against Mastitis in Sheep

Katsafadou

Politis

Mavrogianni

et al. 2019

Animals

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Simple SummaryThe article reviews the defence mechanisms and the relevant processes that occur in the udder of sheep. Due to the importance of the udder in milk production, animals display many defences to protect the organ. These include the teats, the epithelial and the white-blood cells in the udder, the immunoglobulins and chemical substances that all participate in the various processes. These are influenced by many factors, animal- or management-regulated, which must be taken into account in the formulation of prevention schemes against mastitis in sheep.AbstractThe objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement system and chemical antibacterial agents, to describe cooperation and interactions between them and to elaborate on potentials regarding their significance in mammary immunisation strategies. The teat of the udder provides initial protection to the mammary gland. The mammary epithelial cells synthesise antibacterial proteins and the leucocytes produce various inflammation mediators (cytokines or chemokines), phagocytose bacteria and recognise antigenic structures. In the mammary gland, four immunoglobulins (IgG1, IgG2, IgM and IgA) have important roles against bacterial pathogens. The complement system is a collection of proteins, participating in the inflammatory process through various pathways. Other components contributing to humoral mammary defence include lactoferrin, lysozyme and the lactoperoxidase/myeloperoxidase systems, as well as oligosaccharides, gangliosides, reactive oxygen species, acute phase proteins (e.g., haptoglobin and serum amyloid A), ribonucleases and a wide range of antimicrobial peptides. Management practices, genetic variations and nutrition can influence mammary defences and should be taken into account in the formulation of prevention strategies against ovine mastitis.

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Use of proteomics in the study of microbial diseases of small ruminants

Cited by 8 publications

References 90 publications

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Biomarkers of fitness and welfare in dairy cattle: healthy productivity

Role of staphylococci in mastitis in sheep

Mammary Defences and Immunity against Mastitis in Sheep

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