Use of Prostaglandin F2α for Early Pregnancy Termination in the Mismated Bitch

Romagnoli, Stefano; Cela, M.; Camillo, Francesco

doi:10.1016/s0195-5616(91)50055-3

Cited by 30 publications

(12 citation statements)

References 13 publications

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“…The observed luteolytic response of the canine CL to systemic application of PGF2a agonists (Concannon & Hansel 1977, Romagnoli et al 1991 does not contradict this hypothesis as the CL rather constantly express the PGF2a receptor (PTGFR) following its formation around day 15 after ovulation (Kowalewski et al 2008a).…”

Section: Introductionmentioning

confidence: 90%

Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition

et al. 2010

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Expression of cyclooxygenase 2 (COX2, now known as PTGS2), prostaglandin E2 synthase (PTGES, PGES), and prostaglandin F2a synthase (PGFS), of the respective receptors PTGFR (FP), PTGER2 (EP2), and PTGER4 (EP4) and of the progesterone receptor (PGR, PR) was assessed by real-time PCR, immunohistochemistry (IHC), or in situ hybridization (ISH) in utero/placental tissue samples collected from three to five bitches on days 8-12 (pre-implantation), 18-25 (post-implantation), and 35-40 (mid-gestation) of pregnancy and during the prepartal luteolysis. Additionally, ten mid-pregnant bitches were treated with the antiprogestin aglepristone (10 mg/kg bw (2!/24 h)); ovariohysterectomy was 24 and 72 h after the second treatment. Plasma progesterone and 15-ketodihydro-PGF2a (PGFM) concentrations were determined by RIA. Expression of the PGR was highest before implantation and primarily located to the endometrium; expression in the placenta was restricted to the decidual cells. PTGS2 was constantly low expressed until mid-gestation; a strong upregulation occurred at prepartal luteolysis concomitant with an increase in PGFM. PGFS was upregulated after implantation and significantly elevated through early and mid-gestation. PTGES showed a gradual increase and a strong prepartal upregulation. PTGFR, PTGER2, and PTGER4 were downregulated after implantation; a gradual upregulation of PTGFR and PTGER2 occurred towards parturition. ISH and IHC co-localized PGFS, PTGFR, PTGES, and PTGS2 in the trophoblast and endometrium. The changes following application of aglepristone were in the same direction as those observed from mid-gestation to prepartal luteolysis. These data suggest that the prepartal increase of PGF2a results from a strong upregulation of PTGS2 in the fetal trophoblast with the withdrawal of progesterone having a signalling function and the decidual cells playing a key role in the underlying cell-to-cell crosstalk.

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Section: Introductionmentioning

confidence: 90%

Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition

et al. 2010

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Section: Investigations Into a Likely Role Of Pgf2a As A Luteolytic Fmentioning

confidence: 99%

“…Exogenously applied PGF2a or one of its analogues induces luteolysis during the second half of luteal lifespan; however, treatment is not well tolerated as relatively high dosages and⁄or repeated treatments are necessary (Arnold et al 1988;Romagnoli et al 1991). Thus, it was concluded by Hoffmann et al (1996) that such a treatment does not mimic an endogenous mechanism but is based on other pharmacodynamic effects.…”

Section: Investigations Into a Likely Role Of Pgf2a As A Luteolytic Fmentioning

confidence: 99%

The Corpus Luteum of the Dog: Source and Target of Steroid Hormones?

Papa

Hoffmann

2011

Reprod Domestic Animals

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Aim of this paper is to review our present understanding on the endocrine control of luteal function in the bitch and to add some new data generated in our laboratories in support of the hypothesis of a paracrine/autocrine role of corpus luteum (CL) derived steroid hormones. Luteal lifespan in non-pregnant dogs often exceeds that of pregnant dogs, where luteal regression terminates in a rapid luteolysis, immediately prior to parturition. In non-pregnant dogs, luteal regression occurs independently of a uterine luteolysin and in spite of increased gonadotropic support during the last third of dioestrus. The CL is the only source of progesterone (P(4)) maintaining pregnancy, and they have the capacity to synthesize oestrogens as substantiated by expression of the CYP19 (aromatase) gene observed in this study. Our data demonstrated that lutein and non-lutein cells of the canine CL express in a rather constant manner the progesterone receptor (PR) and the oestrogen receptor, classifying them as targets for an autocrine/paracrine activity of CL-derived steroids. Therefore, a functional role of P(4) within a positive loop feedback system, including StAR and 3β-hydroxysteroid dehydrogenase, has been postulated.

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“…Another drug shown to be effective for canine pregnancy termination is prostaglandin F 2α (PGF 2α ) or its analogues. Several doses and regimens of application have been described to induce abortion in bitches (Concannon and Hansel 1977; Vickery and McRae 1980; Romagnoli et al. 1991, 1993; Fieni et al.…”

Section: Introductionmentioning

confidence: 99%

“…Another drug shown to be effective for canine pregnancy termination is prostaglandin F 2a (PGF 2a ) or its analogues. Several doses and regimens of application have been described to induce abortion in bitches (Concannon and Hansel 1977;Vickery and McRae 1980;Romagnoli et al 1991Romagnoli et al , 1993Fieni et al 1997). However, prostaglandins have strong side effects like hyperpnea, hypersalivation, vomiting, defecation, diarrhoea, micturition, tachycardia, lactation, nesting and transient hypothermia (Van der Horst and Vogel 1977;Oettle´1982;Paradis et al 1983;Feldman et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Partial Foetal Retention Following Aglepristone Treatment in a Bitch

Rigau

Rodríguez‐Gil

García

et al. 2010

Reprod Domestic Animals

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This short communication describes the case of partial foetal retention in an 18-month-old female French bulldog following induction of abortion owing to an undesired mating. Abortion was induced with aglepristone administered in two consecutive protocols of a dual injection 1 day apart. After failure of the first treatment to achieve abortion, 15 days later, a second treatment was administered. Delivering of aborted foetus occurred 2 days after the last administration. Five weeks after the abortion, the female showed a weak haemorrhagic vaginal discharge. On ultrasound examination, the presence of uterine wall distension as well as a puppy skull inside the uterus was observed. This clinical case makes clear that although aglepristone is a very reliable drug, follow-up of the female during treatment and in the immediate post-partum is necessary to ensure a good outcome.

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Use of Prostaglandin F2α for Early Pregnancy Termination in the Mismated Bitch

Cited by 30 publications

References 13 publications

Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition

Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition

The Corpus Luteum of the Dog: Source and Target of Steroid Hormones?

Partial Foetal Retention Following Aglepristone Treatment in a Bitch

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