Use of Propranolol in Dysfunctional Labour

Mitrani, A; Oettinger, Moshe; Abinader, Edward G.; Шарф, М; Klein, Alan F.

doi:10.1111/j.1471-0528.1975.tb00701.x

Cited by 34 publications

(7 citation statements)

References 12 publications

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“…When the drug was administered intravenously just before induction of anaesthesia for elective Caesarean section, most of the newborn infants were found to have transient respiratory depression (Tunstall, 1969). Studies in animals and man (Amy and Karim, 1974;Barden and Stander, 1968;Mitrani et al, 1975;Shabanah et al, 1968) have shown that propranolol, administered parenterally, increases uterine muscle tone and this could have adverse effects on the fetus. When sheep fetuses received propranolol intravenously and then had their umbilical cords occluded, a fall, instead of the usual rise, was noted and the propranololtreated sheep fetus also failed to get rebound tachycardia which normally occurs after the end of cord compression (Joelsson and Barton, 1969).…”

Section: Discussionmentioning

confidence: 99%

Propranolol for the Treatment of Hypertension in Pregnancy

Eliahou

Silverberg

Reisin

et al. 1978

BJOG

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Twenty-five women were treated with propranolol during 26 pregnancies complicated by hypertension. The fetal wastage, which had been 48 per cent before treatment with propranolol was reduced to 15.4 per cent, with one missed abortion and three stillbirths. Of the 22 liveborn infants 2 were small-for-dates but all 22 had Apgar scores of 9 or 10 at five minutes. There were no congenital anomalies in 25 viable infants and none of the 22 liveborn infants had clinical or laboratory evidence of hypoglycaemia. The blood pressure was controlled in 17 of 19 patients taking propranolol alone (40 to 160 mg/day) and in 6 of 7 taking propranolol with diuretics.

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Section: Discussionmentioning

confidence: 99%

Propranolol for the Treatment of Hypertension in Pregnancy

Eliahou

Silverberg

Reisin

et al. 1978

BJOG

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“…Cesarean section rate was significantly lower in the propranolol group without maternal and neonatal side effects 16 . The first uncontrolled study on the use of propranolol in dysfunctional labor that was done about four decades ago, reported some promising results 17 . Sanchez-Ramos et al compared the effect of oxytocin plus intravenous propranolol infusion with oxytocin plus placebo in abnormal active phase of labor.…”

Section: Propranololmentioning

confidence: 99%

Factors Affecting the Labor : A Review Article

Direkvand-Moghadam¹,

Delpisheh²,

Rezaeian³

et al. 2013

Biomed. Pharmacol. J.

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The aim of this review is to describe pharmacological and non-pharmacological factors that have an effect on duration of the labor. Approximately all published articles from 1980-2013 in Medline and Embase were searched amongst them 118 articles were selected. The eligible studies were those that reported the labor length, labor duration and active labor. Studies including preterm, premature and labor induction were excluded and finally fifty-six articles were reviewed. Oxytocin, propranolol, Pethidine, Epidural analgesia, Nitrous Oxide and Intravenous Hydration are common pharmacological methods affecting the labor duration. Massage, Birth ball, Acupressure, Oral carbohydrate intake, Presence of companionship, Water birth delivery and Parturient position are considered as the main effective non-pharmacological methods on labor duration. Implementation of non-pharmacological methods, as effective factors on labor duration, is recommended.

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“…Oxprenolol, 1-[(methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-2-propanol, is a nonselective b blocker recognized as being an important drug and usually prescribed for the treatment of hypertension, angina pectoris, migraine, and dysfunctional labor (1)(2)(3). Most assay methods for oxprenolol available in the literature are suitable for its determination in biological fluids such as serum and urine (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%