Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles.

Suresh, U R; Hale, R J; Fox, H.; Buckley, C. H.

doi:10.1136/jcp.46.1.48

Cited by 28 publications

(12 citation statements)

References 19 publications

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“…,atients There was a significant difference between nd the the Ki67 indexes of the first trimester and ic inditerm placentas. This supports the previous findings that there was very active growth of ion of the trophoblast in the first trimester placentas, ns has and such villous trophoblast growth is much gists in diminished in term placenta.23 27 Thus Ki67 ly used expression seems to have a logical correlation 7 Ki67. with the proliferative activity in normal plaprotein centas.…”

Section: Resultssupporting

confidence: 87%

Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.

Cheung

Ngan

Collins

et al. 1994

Journal of Clinical Pathology

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Aims-To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. Methods-Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIBI. Results-Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions. Among the 87 patients with hydatidiform moles studied, 20 developed persistent gestational trophoblastic disease and required subsequent treatment. There was no statistically significant difference in the Ki67 index between the 20 patients who developed persistent disease and those who did not. Conclusion-Hydatidiform moles whichgive rise to persistent trophoblastic disease do not have a higher proliferative rate than those which do not. The Ki67 index is not useful for predicting the prognosis of molar pregnancies.

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Section: Resultssupporting

confidence: 87%

Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.

Cheung

Ngan

Collins

et al. 1994

Journal of Clinical Pathology

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“…Previous studies investigating the proliferation rate of trophoblast, especially those using PCNA immunostaining, have generated considerable controversy. Suresh et al ., 7 Jeffers et al ., 24 Schammel and Bocklage 3 and our team 5 reported that the PCNA index had limited use in differentiating molar and non‐molar trophoblast or CM from PM and could not be applied as a reliable marker for predicting the outcome of HM. In contrast, Ostrzega et al ., 4 Ozbilim et al 27 .…”

Section: Discussionmentioning

confidence: 93%

“…Quantitative assessment of immunoreactivity for proliferating cell nuclear antigen (PCNA) and Ki67 antigen (MIB1) is the most frequently used method for the study of cell proliferation in cancer. Most previous reports on these two markers suggest that Ki67 is useful and may be better than PCNA in the differential diagnosis of GTD 3–8 . Staining for PCNA can be associated with technical challenges and is limited to fixed, paraffin‐embedded tissues 9 .…”

Section: Introductionmentioning

confidence: 99%

Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters

Xue¹,

Khoo²,

Ngan³

et al. 2003

Histopathology

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“…There have been attempts to differentiate between complete mole (CM), partial mole (PM) and hydropic abortion (HA) using morphological 1 , morphometric 2 and proliferative indices 3 . In each instance authors fail to appreciate that villous size, appearance and proliferative activity of trophoblast vary as pregnancy advances and no corrections are made for gestational age 4 .…”

Section: Introductionmentioning

confidence: 99%

A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non‐molar hydropic abortions

et al. 1996

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We have compared the clinical and histological features of 149 complete moles with 146 triploid partial moles and 107 diploid non-molar hydropic abortions initially registered as moles for human chorionic gonadotrophin (hCG) follow-up. Forty-one patients with complete moles, five with partial moles and one with hydropic abortion received chemotherapy for hCG elevations interpreted as persistent trophoblastic disease. Complete moles were aborted or were evacuated significantly earlier than partial moles (means of 12.1 and 15.4 weeks; P < 0.001) and hydropic abortions significantly earlier than complete moles (mean 10.7 weeks; P < 0.005). The means of the highest recorded hCG were higher in complete moles (184,056 i.v.) than in partial moles (66,259 i.v.) and hydropic abortion (7942 i.v.). When hCG became normal without chemotherapy, this occurred earlier in patients with hydropic abortion than in those with partial moles (means of 46.7 days and 62.8 days; P < 0.001) and earlier in partial moles than in complete moles (mean 78.3 days; P < 0.005). The incidence of partial moles was comparable throughout fertile years but rose to 1.9 times the average after 40 years. Complete moles were commoner between 14 and 25 years and after 35 years, reaching 4.8 times the average after 40 years. Hydropic abortions were rare before 25 years and increased with age to 12 times the average after 40 years. Stromal karyorrhexis and shape of villi, before they become hydropic, discriminate well between complete and partial mole. Hydrops increased and vascularity decreased with molar age and the presence of non-hydropic villi or vessels did not discriminate between partial mole and the younger complete moles evacuated nowadays.

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Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles.

Cited by 28 publications

References 19 publications

Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.

Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.

Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters

A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non‐molar hydropic abortions

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