Use of prognostic factors of rheumatoid arthritis in clinical practice and perception of their predictive capacity before and after exposure to evidence

Otón, Teresa; Carmona, Loreto; Calvo‐Alén, Jaime; Escudero, Alejandro; Narváez, Javier; Heredia, José Manuel Rodríguez; Yuste, Susana Romero; Vela, Paloma; Valdés, Sara Luján; García, Ana Royo; Baquero, José Luis

doi:10.1007/s00296-018-4152-8

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…In a disease with progressive characteristics, such as RA, markers related to its progression are very important. Disease activity, the number of swollen joints, auto antibody positivity, and the presence of erosion are the most important prognostic markers [ 25 ]. Many studies have been conducted on the prognosis of the disease with US.…”

Section: Ultrasonography For Rheumatoid Arthritismentioning

confidence: 99%

Musculoskeletal ultrasonography in rheumatic diseases

ÇAPKIN

2023

Turkish Journal of Medical Sciences

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Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in patients with rheumatic disease. Musculoskeletal ultrasonography is becoming a preferred imaging technique for rheumatic diseases, as it has many advantages. Among its advantages are being inexpensive, being radiation-free, having a dynamic image capacity, helping to detect disease activity, and helping with early detection and diagnosis of structural damage. This review summarizes the use of ultrasonography in rheumatic diseases.

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Section: Ultrasonography For Rheumatoid Arthritismentioning

confidence: 99%

Musculoskeletal ultrasonography in rheumatic diseases

ÇAPKIN

2023

Turkish Journal of Medical Sciences

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“…2,[9][10][11] MTX treatment outcomes in RA are in uenced by various factors. Age, 12,13 sex, disease activity, obesity, 13,14 smoking history, 12 genetics, 14,15 swollen and tender joints, 16 erosion on radiographs, 13 longer disease duration, 12,13 extra-articular manifestations, 17 and comorbidities 13 have all been reported to impact MTX treatment outcomes in prior studies. Additionally, laboratory factors such as acute phase reactants (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]), 18 serological markers like rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA), interleukin-2 (IL-2), and receptor activator of nuclear factor kappa-B ligand (RANKL) 13,15 have shown to in uence treatment response across various studies.…”

mentioning

confidence: 99%

Predictive Factors of Methotrexate Monotherapy Success in Patients with Rheumatoid Arthritis in a National Referral Center: A Cohort Study

Hidayat,

Fauzia,

Parlindungan

et al. 2024

Preprint

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Background Methotrexate (MTX) remains the recommended first-line treatment for rheumatoid arthritis (RA); however, its response varies and is influenced by various factors. This study aimed to identify predictors of MTX monotherapy treatment success in an Indonesian cohort. Methods This retrospective cohort study included newly diagnosed RA patients receiving MTX monotherapy. Treatment success was defined as achieving remission or low disease activity according to Disease Activity Score-28 with erythrocyte sedimentation rate (DAS28-ESR) after 12 months of MTX therapy. The association between demographic, clinical, and laboratory factors and achieving therapy targets was evaluated using multivariate logistic regression analysis. Results Among 254 subjects, 59.4% achieved treatment success with MTX monotherapy, with remission attained in 33% and low disease activity in 26.4%. Most subjects were female (95.7%) with a mean age of 48 ± 11 years. Multivariate analysis revealed that lower disease activity (OR 1.97; 95% CI [1.04–3.72]), normal ESR (OR 2.58; 95% CI [1.05–6.34]), normoweight (OR 2.55, 95% CI [1.45–4.49]), and tender joint count ≤ 5 (OR 2.45, 95% CI [1.31–4.58]) were significant predictors of treatment success. Conclusion The rate of MTX monotherapy success in our study was 59.4%. Lower disease activity, normal ESR, normoweight, and fewer tender joints at baseline were significant predictors of treatment success.

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“…Several predictors of remission have been previously reported such as sociodemographic (age, sex, disease duration) features, harmful habits, autoantibodies (rheumatoid factor [RF] and anti-cyclic citrullinated peptide [CCP]), and clinical (joint counts, activity scores, disability) or treatment (type and strategy) features. 10,11 Determining these predictors in daily clinical practice could help us define homogeneous groups of patients in terms of response to treatment, but also offer management alternatives to those with adverse predictive features.…”

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confidence: 99%

Predictors of Remission and Low Disease Activity in Rheumatoid Arthritis Patients

et al. 2022

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Background: Clinical remission is the goal in rheumatoid arthritis (RA) management; however, this can be difficult to achieve in several parts of the world. Our objective was to determine predictors of remission and remission/ low disease activity (LDA) in RA.Methods: A longitudinal real-setting RA cohort was followed up (January 2016-2020). Predictors examined were sex, age at diagnosis, disease duration, socioeconomic status, tobacco use, rheumatoid factor titer, comorbidities (Charlson index), Simple Disease Activity Index (SDAI) score, disability (Multidimensional Disease Health Assessment Questionnaire), health-related quality of life (Short Form-36 questionnaire), glucocorticoid dose, biological/target synthetic disease-modifying antirheumatic drugs, and conventional DMARD (c-DMARD) use. Univariable and multivariable generalized estimating equation models were done to determine predictors of remission (at a given visit) and sustained remission (2 consecutives visits), using the SDAI definition (0 or <3.3). Similarly, remission/ LDA (SDAI <11) predictors were examined.Results: Five hundred thirty RA patients included the following: 160 patients (30.2%) achieved remission in at least 1 visit, and 126 patients (23.77%) achieved sustained remission. On the multivariable analysis glucocorticoid dose

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Use of prognostic factors of rheumatoid arthritis in clinical practice and perception of their predictive capacity before and after exposure to evidence

Cited by 9 publications

References 19 publications

Musculoskeletal ultrasonography in rheumatic diseases

Musculoskeletal ultrasonography in rheumatic diseases

Predictive Factors of Methotrexate Monotherapy Success in Patients with Rheumatoid Arthritis in a National Referral Center: A Cohort Study

Predictors of Remission and Low Disease Activity in Rheumatoid Arthritis Patients

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