Use of Preventive Aspirin Among Older US Adults With and Without Diabetes

Liu, Elizabeth Y.; Al-Sofiani, Mohammed E.; Yeh, Hsin Chieh; Echouffo‐Tcheugui, Justin B.; Joseph, Joshua J.; Kalyani, Rita R.

doi:10.1001/jamanetworkopen.2021.12210

Cited by 25 publications

(32 citation statements)

References 29 publications

(63 reference statements)

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“…However, the unwarranted use of aspirin was found to be low as only 5.1% were using aspirin upon recommendation of a non-physician such as family or friends. These findings are consistent with a paper written by Liu et al [ 11 ]. Based on their accounts, 61.7% of older American patients with diabetes mellitus (DM) were aspirin users whereas 42.2% of those without DM were also reported to be taking the medication.…”

Section: Discussionsupporting

confidence: 94%

“…In Denmark [ 14 ], aspirin use was independently associated with age, however, researchers pointed out that due to the widespread use of aspirin including the concomitant use of other medications specifically among older adults, the incidence of major bleeding became an issue suggesting that appropriate measures should be in place to limit the misuse of aspirin. Contradicting these reports, a study conducted among Chinese patients [ 11 ], found that among patients with diabetes, the likelihood of aspirin use did not differ significantly by age, and the level of cholesterol was also negatively associated with aspirin use while patients in low-level hospitals were more likely to exhibit inappropriate use of the medication.…”

Section: Discussionmentioning

confidence: 99%

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A Cross-Sectional Study on the Prevalence of Self-Prescribed Aspirin Use for Prevention of Adverse Ischemic Vascular Events Among Moderate-Risk Individuals: A Single Center Study

Almulhim

Mulhim

Nasser

et al. 2023

Cureus

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Introduction Despite the overwhelming amount of evidence against the use of aspirin for primary prophylaxis of cardiovascular disease (CVD), the arguably unwarranted use of aspirin has increased over the years, which may or may not be based on any specific medical advice, and merely self-prescribed. Aim This study aimed to determine the prevalence of unwarranted aspirin use among moderate-risk individuals for the primary prevention of adverse vascular events in Saudi Arabia. Patient and method A cross-sectional study was conducted among 100 patients who presented to the emergency room (ER) due to suspected cardiac diseases. The data were collected from the patients who visited ER in King Fahad Hospital, Al-Hofuf, Saudi Arabia. Participants were asked about their socio-demographic characteristics, aspirin use habits, and their comorbidities. Results Of the 100 patients, 35% were aged more than 60 years old. The overall use of aspirin was 78%. The prevalence of aspirin use was significantly more common among the older age group (53.8%), those with associated chronic diseases, such as diabetes (59%) and hypertension (75.6%) and those with a previous history of hospitalization due to stroke or a cardiac event (66.7%). Conclusion The use of aspirin among patients who are at moderate risk of cardiovascular events was widely prevalent, but their unwarranted use was low. Older patients with chronic diseases who believed in its great benefit and tended to ignore its complications are the most common users of aspirin. More research is recommended to determine the prevalence and the factors associated with unwarranted use of aspirin in patients with CVD in our region.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Prevalence of Self-Prescribed Aspirin Use for Prevention of Adverse Ischemic Vascular Events Among Moderate-Risk Individuals: A Single Center Study

Almulhim

Mulhim

Nasser

et al. 2023

Cureus

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“…The foremost consideration for the appropriate use of drugs in a preventive manner would be the strict adherence to the recent changes in clinical guidelines. For example, from 2011–2018, the prevalence of aspirin use among older US adults (≥60 years) was high among individuals at an increased risk for bleeding and other adverse events [ 16 ], despite recent changes in the guidelines of the American Heart Association, American Diabetes Association and USPSTF. Moreover, other considerations should be considered before the initiation or continuation of preventive medications use, such as age, multimorbidity, number of other medications and updated guidelines.…”

Section: Discussionmentioning

confidence: 99%

Preventive Medication Use among Adults Aged 40 and over in the United States: National Health and Nutrition Examination Survey, 2015–2018

Meraya

2022

Healthcare

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Objectives: 1. To estimate the prevalence of preventive medication use among adults in the United States (US); 2. To identify the socioeconomic, demographic and clinical factors associated with preventive prescription medication use; 3. To identify the diagnoses associated with preventive prescription medication use. Methods: Data from two cycles of the National Health and Nutrition Examination Survey, 2015–2016 and 2017–2018, are analyzed. Results: Among US adults aged 40 years or older (N = 7634), 31% use a preventive medication. Specifically, 27% of them use aspirin and 9% use other preventive prescription medications. Among those who use other preventive prescription medications, 27% report using one of the cardiovascular agents and 24% reported using anticoagulants and/or antiplatelet agents. High percentages of preventive prescription medication users report using medications to prevent heart attacks/myocardial infarctions (25%) or blood clots (23%). Uninsured adults are less likely to use preventive medications (OR: 0.656; p-value = 0.009) as compared with their counterparts with private insurance. On the other hand, older adults and those with diabetes, heart disease, arthritis and hypertension are more likely to use preventive medications. Furthermore, past smokers and adults who never smoked are more likely to use preventive medications as compared with those who currently smoke. Conclusion: Policies are needed to increase access to preventive care for uninsured adults. Further research needs to review the benefits and harms of the chronic use of preventive medication among older adults in the US.

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“…For a long time, people who have one or more risk factors for cardiovascular disease (CVD) have been recommended to take aspirin, one of the most often used drugs, to prevent CVD ( Ittaman et al, 2014 ). According to estimates, 46.7% of US individuals aged 60 or older reported using aspirin to prevent CVD events ( Liu et al, 2021 ). However, no consensus was established between the various guidelines committees on whether or how to use aspirin for primary prevention ( Patrono and Baigent, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Low- or high-dose preventive aspirin use and risk of death from all-cause, cardiovascular disease, and cancer: A nationally representative cohort study

Chen

Chen²,

Liao³

et al. 2023

Front. Pharmacol.

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Background and aim: For a long time, aspirin has been recommended for the prevention of cardiovascular disease (CVD). However, results of long-term effects of aspirin use on the risk of CVD and all-cause death as well as cause-specific mortality are not consistent. This study aims to investigate the relationship between low- or high-dose preventive aspirin use and the risk of death from all-cause, CVD, and cancer among US adults aged 40 years and older.Methods: A prospective cohort study was conducted by utilizing four cycles of the National Health and Nutrition Examination Survey (NHANES) and linked 2019 mortality files. Cox proportional hazard models accounting for multiple covariates were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for the associations between low- or high-dose aspirin use and risk of death.Results: A total of 10,854 individuals (5,364 men and 5,490 women) were enrolled in the study. During a median follow-up of 4.8 years, 924 death events including 294 CVD death and 223 cancer death were documented. We found no evidence that taking low-dose aspirin decreased the chance of dying from any cause (HR: 0.92, 95% CI: 0.79–1.06), CVD (HR: 1.03, 95% CI: 0.79–1.33), or cancer (HR: 0.80, 95% CI: 0.60–1.08). High-dose aspirin users had a higher risk of CVD death compared to participants who had never used aspirin (HR: 1.63, 95% CI: 1.11–2.41).Conclusion: Using low-dose aspirin has no effect on the risk of death from any causes, whereas taking high doses of aspirin increases the risk of CVD death.

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Use of Preventive Aspirin Among Older US Adults With and Without Diabetes

Cited by 25 publications

References 29 publications

A Cross-Sectional Study on the Prevalence of Self-Prescribed Aspirin Use for Prevention of Adverse Ischemic Vascular Events Among Moderate-Risk Individuals: A Single Center Study

A Cross-Sectional Study on the Prevalence of Self-Prescribed Aspirin Use for Prevention of Adverse Ischemic Vascular Events Among Moderate-Risk Individuals: A Single Center Study

Preventive Medication Use among Adults Aged 40 and over in the United States: National Health and Nutrition Examination Survey, 2015–2018

Low- or high-dose preventive aspirin use and risk of death from all-cause, cardiovascular disease, and cancer: A nationally representative cohort study

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