Use of prescription drugs among women diagnosed with epithelial ovarian cancer in Denmark

Pottegård, Anton; Friis, Søren; Verdoodt, Freija; Dehlendorff, Christian; Hallas, Jesper; Kjær, Susanne K.

doi:10.1111/aogs.13413

Cited by 4 publications

(2 citation statements)

References 30 publications

(56 reference statements)

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“…Blood sampling frequency and other measures of primary care activity have been described in specific cancer diagnoses before showing increased activity 1-2 years before the diagnosis [1,18]. This study, however, shows a considerably longer period with increased laboratory work-up for hematological patients and CNS tumors going back more than 5 years prior to the diagnosis.…”

Section: Comparison With the Literaturementioning

confidence: 61%

Blood sampling patterns in primary care change several years before a cancer diagnosis

Christensen,

Grand,

Kriegbaum

et al. 2024

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BackgroundA sudden increase in blood sample requisitions from primary care physicians may indicate an incentive to investigate certain symptoms further. Patients with slowly progressing malignancies may debut with insidious symptoms and seek medical attention with increasing frequency, which indeed has been demonstrated through different markers of primary care activity in the last 1-2 years prior to a cancer diagnosis [1,2]. However, within hematological malignancies in particular, early signs of slowly progressing or pre-malignant conditions may in fact be detectable several years before the malignant disease is diagnosed [3][4][5]. Identifying early signs of malignancy or pre-malignancy is important in order to increase chances of successful treatment and lower morbidity and mortality [6][7][8]. Even in asymptomatic and otherwise low-risk hematological patients, it has been demonstrated that early detection may enable risk stratification for follow-up of the (pre-)malignant conditions, help provide relevant care and improve early disease detection in the right patients [9]. In this descriptive study we aimed to describe the pre-diagnostic activity in primary care going back 15 years prior to the malignant diagnosis in order to explore if laboratory activity may indicate that early (pre-)malignant conditions register in primary care years before a diagnosis is made. This was done by describing the blood sampling activity patterns in primary care in both cancer patients to-be and controls, looking at both solid tumors and hematological malignancies. The overall aim of the study was to evaluate the potential for earlier diagnosis of certain malignant diseases. Methods PopulationCancer cases consisted of patients in the greater Copenhagen area with a malignant diagnosis registered in the exhaustive LETTER CONTACT Mathilde Egelund Christensen

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Section: Comparison With the Literaturementioning

confidence: 61%

Blood sampling patterns in primary care change several years before a cancer diagnosis

Christensen,

Grand,

Kriegbaum

et al. 2024

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“…Descriptions of these medication changes can help improve clinical decision making or understanding of medication and disease trajectories. However, they are methodologically challenging as the data needs to be analyzed either prospectively, i.e., anchoring the timeline to a clinical event [ 8 , 9 ], or retrospectively, i.e., anchoring the timeline at death [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer

Johansson,

Petersen,

Christensen

et al. 2023

Drugs Aging

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Introduction Certain clinical events reduce life expectancy and necessitate a reassessment of patient treatment. Objective To describe medication changes in relation to a cancer diagnosis and the end of life and to highlight challenges and limitations with such descriptions. Methods From a cohort with all Danish patients with type 2 diabetes, we matched patients with incident cancer during 2000–2021 ( n = 41,745) with patients without cancer ( n = 166,994) using propensity scores. We described their medication usage from cancer diagnosis until death. Results The 1- and 5-year mortality were 51% and 86%, respectively, in the cancer group, and 13% and 59% in the non-cancer group. In relation to cancer diagnosis and death, the use of symptomatic medications (e.g., opioids, benzodiazepines) increased (10–60 incident medications per 100 patient-months), and the use of preventive medications (e.g., antihypertensives, statins) decreased (5–30% fewer users). The changes in relation to the diagnosis were driven by patients with short observed lengths of survival (< 2 years). In contrast, changes occurring within a year before death were less dependent on survival strata, and > 60% used preventive medications in their last months. Conclusions Medication changes in relation to a cancer diagnosis were frequent and correlated to the length of survival. The results showcase the challenges and limited clinical utility of anchoring analyses on events or death. While the former diluted the results by averaging changes across patients with vastly different clinical courses, the latter leveraged information unavailable to the treating clinicians. While medication changes were common near death, preventive medications were often used until death. Supplementary Information The online version contains supplementary material available at 10.1007/s40266-023-01062-0.

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Detection of potential drug-drug interactions among ovarian cancer patients in a tertiary care teaching hospital in South India- A retrospective approach

Rawal

Mateti

Shetty

et al. 2023

Clinical Epidemiology and Global Health

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Use of prescription drugs among women diagnosed with epithelial ovarian cancer in Denmark

Abstract: Drug use among postmenopausal women with epithelial ovarian cancer was substantial and varied considerably in relation to the time of cancer diagnosis, although only limited changes were seen in the use of preventive medicines.

Cited by 4 publications

References 30 publications

Blood sampling patterns in primary care change several years before a cancer diagnosis

Blood sampling patterns in primary care change several years before a cancer diagnosis

Methodological Considerations for Describing Medication Changes in Relation to Clinical Events and Death: An Applied Example in Patients with Type 2 Diabetes and Cancer

Detection of potential drug-drug interactions among ovarian cancer patients in a tertiary care teaching hospital in South India- A retrospective approach

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