Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates

Fujita, Hiroshi; Teratani, Miyuki; Hazama, Yuki; Nakahara, Michiyo; Asaka, Hiroyuki; Nishimura, Shigeko

doi:10.1111/trf.14897

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…For the experiment, we prepared aqueous solutions with different ammonia contents in the range of 0.125–1 mmol·L –1 corresponding, on one hand, to the critical value making the water toxic and, on the other hand, found in blood, gastric juice, sweat, urine, and exhaled air . Typically, characterization of the sensor sensitivity is given in ppm units.…”

Section: Results and Discussionmentioning

confidence: 99%

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Kondrat'ev¹,

Морозов²,

Vyacheslavova

et al. 2022

ACS Appl. Nano Mater.

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Nanowires represent numerous opportunities for nanoelectronics and sensorics, while metal contact fabrication makes the device development rather challenging. Here, we demonstrate that silicon (Si) nanowires deposited on interdigital metal contacts via simple drop casting exhibit an abrupt increase in conductivity upon exposure to ammonia vapors and aqueous solutions due to adsorption of the analyte species. To reduce the noise of the DC resistance measurements lacking ohmic conductivity, we exploit electronic impedance spectroscopy. The resistive response is found to be dependent on the ammonia content in vapor and liquid matter. The results demonstrate a detection limit of 4 μmol•L −1 (80 ppb), a sensitivity of 0.2% μmol −1 •l (0.01%•ppb −1 ), and applicability for the low-concentration detection of up to 400 μmol•L −1 (8 ppm) ammonia in aqueous solutions both directly and indirectly with a response rate of up to 0.43%•s −1 and a recovery rate of 0.31%•s −1 and show selectivity to oxidizing species. Thus, we demonstrate that the use of semiconductor nanowires in adsorption sensorics does not require the fabrication of ohmic contacts and present a simple fabrication protocol perspective for the development of highly sensitive room-temperature multi-environment sensors.

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Section: Results and Discussionmentioning

confidence: 99%

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Kondrat'ev¹,

Морозов²,

Vyacheslavova

et al. 2022

ACS Appl. Nano Mater.

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“…In a human body, HCl is produced by the stomach . Another important analyte is ammonia (NH 3 ) which is a product of putrefaction and decomposition, and found in sweat, blood, urine, and breath . HCl and NH 3 are the biological markers of human health allowing for the detection and analysis of pathological changes in the body, such as gastrointestinal disease, metabolic disorders, and even cancer. ,, …”

Section: Introductionmentioning

confidence: 99%

Si Nanowire-Based Schottky Sensors for Selective Sensing of NH₃ and HCl via Impedance Spectroscopy

Kondrat'ev

Vyacheslavova

Shugabaev³

et al. 2023

ACS Appl. Nano Mater.

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This work is aimed at the development of a highly sensitive silicon (Si)-based sensor allowing for the selective detection and analysis of liquid solution compositions containing ammonia (NH3) and hydrochloric acid (HCl) in an indirect manner using electrochemical impedance spectroscopy (EIS). For optimization of the performance, we develop three types of sensors based on as-fabricated Si nanowires, nanowires treated with hydrofluoric acid (HF), and nanowires decorated with silver (Ag) nanoparticles. The fabricated sensors exhibit good performance governed by the sensitivity of the nanoscale Schottky barriers at the interface between the golden pads and Si nanowires. The best results on sensitivity are obtained with untreated Si nanowires providing a detection limit at the level of 4 μmol·L–1 and resistive sensitivities of 0.8% per μmol·L–1 for HCl and 4 μmol·L–1, −0.2% per μmol·L–1 for NH3, correspondingly. Treatment with HF stimulates the surface oxidation providing higher density of the adsorption sites and found promising for the detection with the analyte content up to 1000 μmol·L–1. In the end, we study the sensor response upon simultaneous exposure under NH3 and HCl vapors using developed approach for the EIS data analysis involving characterization of the sensor response with two parametersresistance and EIS frequency corresponding to the change in the operation regime. Due to the use of two parameters simultaneously, this approach is found as a pathway for qualitative analysis of the gas mixture composition using only one sensor. The results of the work shed light on the development of feasible highly sensitive sensors for health monitoring, allowing for selective mixed analytes detection.

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“…Regardless of infusion rate or total transfused volume, FFP has been independently associated with volume overload and worsen cerebral edema . Unlike other blood products, FFP cannot be washed free of ammonia, thereby increasing serum ammonia levels . Hyperammonemia can further precipitate cerebral edema, herniation, and death by altering neuroglial gene expression to increase astrocyte swelling and cytokine production .…”

Section: Discussionmentioning

confidence: 99%

Eliminating international normalized ratio threshold for transfusion in pediatric patients with acute liver failure

Lee

Mendoza

Brubaker

et al. 2020

Clinical Transplantation

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Introduction Transfusion protocols are not well‐studied for pediatric patients with acute liver failure (ALF). This study evaluates the utility of an international normalized ratio (INR)‐based transfusion threshold for these patients. Methods Forty‐four ALF pediatric patients from 2009 to 2018 were reviewed and divided into two groups: (a) a threshold group including patients between 2009 and 2015 who were transfused for an INR above 3.0, per institutional policy (n = 30), and (b) a post‐threshold group including patients after 2015 through 2018 who were transfused based on clinical judgment (n = 14). Preoperative INRs, preoperative transfusions, intraoperative transfusions, early reoperation, renal function, graft function and deaths were compared. Results Liver failure severity was similar between threshold and post‐threshold groups. Threshold patients had a lower average INR prior to transplantation, 2.8 (range 1.8‐3.8) vs 4.4 (range 2.1‐9.0), respectively (P = .01). Twenty‐six threshold patients (87%) received preoperative FFP compared with seven post‐threshold patients (50%, P = .0088). Two threshold patients (7%) received preoperative cryoprecipitate compared with five post‐threshold patients (36%, P = .014). The incidence of pre‐transplant bleeding, operative transfusions, and 1‐year patient and graft survival did not differ significantly. Conclusion Clinical judgment vs an INR‐based threshold for transfusions did not increase perioperative complications in children with ALF.

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Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates

Abstract: PAF-n can remove ammonia and potassium from RBC solution in small satellite packs. PAF-n could therefore improve the clinical prognosis of neonates with poorly developed BBB by limiting the delivery of excess ammonia found in the RBC solution.

Cited by 8 publications

References 19 publications

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Si Nanowire-Based Schottky Sensors for Selective Sensing of NH₃ and HCl via Impedance Spectroscopy

Eliminating international normalized ratio threshold for transfusion in pediatric patients with acute liver failure

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Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates

Abstract: PAF-n can remove ammonia and potassium from RBC solution in small satellite packs. PAF-n could therefore improve the clinical prognosis of neonates with poorly developed BBB by limiting the delivery of excess ammonia found in the RBC solution.

Cited by 8 publications

References 19 publications

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Silicon Nanowire-Based Room-Temperature Multi-environment Ammonia Detection

Si Nanowire-Based Schottky Sensors for Selective Sensing of NH3 and HCl via Impedance Spectroscopy

Eliminating international normalized ratio threshold for transfusion in pediatric patients with acute liver failure

Contact Info

Product

Resources

About

Si Nanowire-Based Schottky Sensors for Selective Sensing of NH₃ and HCl via Impedance Spectroscopy