Use of Porcine Acellular Dermal Matrix in Revisionary Cosmetic Breast Augmentation

Pozner, Jason N.; White, Jeremy B.; Newman, Martin

doi:10.1177/1090820x13491279

Cited by 41 publications

(31 citation statements)

References 12 publications

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“…This might be particularly important for the decellularized dermis as it went through cell removal during preparation. The decellularized dermis utilized here, Strattice, has been used successfully as an internally placed scaffold for treatment of subcostal hernia repair [ 54 ] and breast reconstruction [ 55 , 56 ]. Mirastschijski et al have found that the decellularized dermis may be best suited for dermal wound beds that require a higher mechanical load than in those previously mentioned [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

In VitroEvaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds

Wahl

Fierro

Peavy

et al. 2015

BioMed Research International

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Mesenchymal stem cells (MSCs) have been shown to improve tissue regeneration in several preclinical and clinical trials. These cells have been used in combination with three-dimensional scaffolds as a promising approach in the field of regenerative medicine. We compare the behavior of human adipose-derived MSCs (AdMSCs) on four different biomaterials that are awaiting or have already received FDA approval to determine a suitable regenerative scaffold for delivering these cells to dermal wounds and increasing healing potential. AdMSCs were isolated, characterized, and seeded onto scaffolds based on chitosan, fibrin, bovine collagen, and decellularized porcine dermis. In vitro results demonstrated that the scaffolds strongly influence key parameters, such as seeding efficiency, cellular distribution, attachment, survival, metabolic activity, and paracrine release. Chick chorioallantoic membrane assays revealed that the scaffold composition similarly influences the angiogenic potential of AdMSCs in vivo. The wound healing potential of scaffolds increases by means of a synergistic relationship between AdMSCs and biomaterial resulting in the release of proangiogenic and cytokine factors, which is currently lacking when a scaffold alone is utilized. Furthermore, the methods used herein can be utilized to test other scaffold materials to increase their wound healing potential with AdMSCs.

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Section: Discussionmentioning

confidence: 99%

In VitroEvaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds

Wahl

Fierro

Peavy

et al. 2015

BioMed Research International

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“…Finally, in a recent study, Pozner et al 36 reported on their initial experience with the use of Strattice for revision surgery in augmentation patients. A total of 179 reoperations were per formed in 93 patients.…”

Section: Summary Of Studies Of Acellular Dermal Matrix-assisted Revmentioning

confidence: 99%

Acellular Dermal Matrix for Reoperative Breast Augmentation

Maxwell¹,

Gabriel²

2014

Plastic and Reconstructive Surgery

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Revisionary breast surgery in previously augmented patients is complex, with many variables that have to be considered. Obtaining durable repairs is challenging because these patients often present with thinned breast tissue, inadequate local tissue, and/or scarred breast envelope from multiple procedures. Capsular contracture, ptosis, tissue atrophy, and wrinkling/rippling are some of the most frequent reasons for reoperation. Conventional repair techniques generally involve a combination of capsule modification (capsular flaps), site change, mastopexy, and implant exchange. Recently, acellular dermal matrices have been introduced into revision surgery to reinforce soft tissue, reinforce the implant pocket, and potentially mitigate capsular contracture. Clinical outcomes of acellular dermal matrix-assisted revision surgery are reviewed from the published literature to evaluate the efficacy and safety of acellular dermal matrices for this indication.

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“…The implant pocket may be enlarged by capsulotomy or capsulectomy, decreased by capsulorrhaphy, or reinforced with part of the capsule or with ADM. [49][50][51][52][53][61][62][63][64] The patient's own dermis can be obtained during simultaneous abdominoplasty and applied to the revision. 65 An existing subglandular pocket can be revised to a subpectoral pocket or vice versa if an adequate amount of soft tissue is present.…”

Section: Pocket Asymmetry or Implant Malpositionmentioning

confidence: 99%

“…80 ADM use also can reduce the risk of capsular contracture. 50,52,63,[81][82][83] Tissue-Related Techniques recurrent Ptosis Correction of recurrent ptosis following augmentationmastopexy involves first identifying the etiology. Patients with this complication typically present with implants that are in good position but with breast tissue that has stretched or descended following weight fluctuations, aging, or pregnancy (Figure 9; Supplemental Figures S6-S9).…”

Section: Pseudoptosismentioning

confidence: 99%

“…[49][50][51][52][61][62][63][64] However, the patient should be informed that the cost of surgery may increase considerably if this adjunct is applied. If ADM is too costly for the patient, the surgeon may incorporate the patient's dermis from a simultaneous abdominoplasty 65 (if planned) or from a revision of a cesarean section, appendectomy, cholecystectomy, or other long abdominal scar.…”

Section: Acellular Dermal Matrixmentioning

confidence: 99%

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Secondary Augmentation-Mastopexy: Indications, Preferred Practices, and the Treatment of Complications

Spring

Macias

Nadeau

et al. 2014

Aesthetic Surgery Journal

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Increasing the volume of the breast while simultaneously decreasing the skin envelope equates to surgery involving opposing forces. Increasing patient demand and the evolving perceptions of surgeons have led to the growing popularity of the combined augmentation-mastopexy operation. In turn, secondary augmentation-mastopexies and revisional surgeries of primary augmentation-mastopexies also have increased in popularity. In this article, the authors describe indications for secondary augmentation-mastopexy, techniques for performing this combined procedure safely and effectively, adjunctive procedures, potential pitfalls, and the treatment of complications.

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Use of Porcine Acellular Dermal Matrix in Revisionary Cosmetic Breast Augmentation

Abstract: Porcine ADM demonstrated great utility as an adjunct in revisionary cosmetic breast surgery. The product helped to provide good aesthetic outcomes with low complication rates. Prospective, randomized trials may prove helpful in defining the role of PADM further in these challenging cases.

Cited by 41 publications

References 12 publications

In VitroEvaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds

In VitroEvaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds

Acellular Dermal Matrix for Reoperative Breast Augmentation

Secondary Augmentation-Mastopexy: Indications, Preferred Practices, and the Treatment of Complications

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