Use of polyunsaturated fatty acids in prevention and treatment of gastrointestinal diseases, obesity and cancer

Abstract

Summary Fatty acids are important structural and functional elements of human body. We can distinguish several types: among others polyunsaturated fatty acids, which include omega-3 fatty acids (ω-3PUFA) and omega-6 fatty acids(ω-6PUFA). The first group has pleiotropic health-promoting effects, while the second group, ω-6PUFA, negatively affects the homeostasis of the human body and contributes to the development of numerous diseases. Both the amount and the relative ratio of these acids in the diet is an important factor affecting health and quality of life. Laboratory and clinical studies indicate that ω-3PUFA have a positive effect on the therapy of illnesses such as obesity and inflammatory bowel disease (IBD). ω-3 PUFA supplementation also appears to have a helpful effect in the adjuvant treatment of colorectal cancer and recovery.