Use of Polysaccharide extracted from Tremella fuciformis Berk for control diabetes induced in rats.

Bach, Erna Elisabeth; Costa, Silvia Goes; Oliveira, Helenita Antônia de; Silva, Jorge; Silva, Keisy Menezes da; Marco, Rogerio Milton De; Hi, Edgar Matias Bach; Wadt, Nilsa Sumie Yamashita

doi:10.9755/ejfa.2015.05.307

Cited by 12 publications

(6 citation statements)

References 23 publications

(18 reference statements)

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“…TP has been shown to regulate blood glucose and lipids ( Elisashvili et al, 2002 ; Bach et al, 2015 ; Chiu et al, 2022 ; Zhang et al, 2023 ), suggesting the possible use of TP for treating obesity and diabetes. Upon proteomic analysis, the expression of 84 genes associated with obesity, insulin resistance, and diabetic complications was significantly decreased ( Kim et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

“…Bark has been used in China for thousands of years due to its unique flavour and positive role in disease prevention and treatment ( Wu et al, 2019 ; Yuan et al, 2022 ). As one of its active components, Tremella polysaccharide (TP) has many pharmacological effects, such as lowering blood glucose and lipid ( Kim et al, 2009 ; Bach et al, 2015 ; Chiu et al, 2022 ; Zhang et al, 2023 )and immunomodulation ( Shi et al, 2014 ; Xiao et al, 2021 ; Khan et al, 2022 ; Xie et al, 2022 ). In addition, the anti-radiation ( Xu et al, 2012 ), anti-ageing ( Tao et al, 2017 ) and antioxidant ( Chen, 2010 ) effects of TP have also been reported.…”

Section: Introductionmentioning

confidence: 99%

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Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Chen

Huang

et al. 2022

Front. Microbiol.

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Obesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. Tremella fuciformis is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic. However, the anti-obesity effects and potential mechanisms of TP have never been reported. This study was conducted to elucidate the inhibitory effect of TP on high-fat diet (HFD)-induced obesity in mice. Mice were split into five groups: normal chow diet (NCD) group, NCD_TP_H group, HFD group, HFD_TP_L group and HFD_TP_H group. Our study showed that TP inhibited high-fat diet-induced weight gain and fat accumulation in mice and reduced blood glucose, hyperlipidemia and inflammation. TP also improved gut microbiota disorders by reducing the Firmicutes/Bacteroidetes ratio and modulating the relative abundance of specific gut microbiota. We also found that the anti-obesity and gut microbiota-modulating effects of TP could be transferred to HFD-fed mice via faecal microbiota transplantation (FMT), confirming that the gut microbiota was one of the targets of TP for obesity inhibition. Further studies showed that TP increased the production of short-chain fatty acids and the secretion of intestinal hormones. Our studies showed that TP inhibited obesity by modulating inflammation and the microbe-gut-brain axis, providing a rationale for developing TP to treat obesity and its complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Chen

Huang

et al. 2022

Front. Microbiol.

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“…78 Tremella polysaccharides can control mild type 1 diabetes (blood glucose <130 mg/dL), by lowering blood cholesterol, triglycerides, glutamate-pyruvate transaminase, urea content and increasing high-density lipoprotein cholesterol. 79 In Elisashvili's study, blood glucose and triglycerides were significantly reduced in a dose-dependent manner after continuously feeding hyperglycemic mice with Tremella polysaccharides for 15 days. 80 The regulation effect of Tremella polysaccharides on blood glucose and blood lipids is related to the activity of glucose metabolising enzymes.…”

Section: Treatment Of Chronic Diseasesmentioning

confidence: 95%

A review on the production, structure, bioactivities and applications of Tremella polysaccharides

Yang

et al. 2021

Int J Immunopathol Pharmacol

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Tremella polysaccharide is known to be structurally unique and biologically active natural products, abundant and versatile in activities and applications in food industry, daily chemical industry and medicine industry. In order to improve the industrialisation of Tremella polysaccharide, the limitations of preparation and structure-activity relationship of Tremella polysaccharide were reviewed in this paper. The research progress of Tremella polysaccharide in the past 20 years was summarized from the sources, preparation methods, molecular structure, activity and application, and the research trend in the future was also prospected. The application prospect of Tremella polysaccharide in against multiple sub-health states was worth expecting.

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“…Among these substances, 1,3-β-glucan constitutes up to 2.5% of the dry weight of the fungus [ 9 ]. Previous studies have demonstrated the potential of β-glucan derived from oats or barley to lower blood glucose, body weight, and plasma lipid levels in vitro, and in animal models [ 10 – 12 ]. Studies in humans have demonstrated that β-glucan obtained from oats or barley efficiently reduced blood glucose, insulin, and lipid levels in healthy subjects [ 13 ] and people with diabetes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Tremella fuciformis beverage improves glycated hemoglobin A1c and waist circumference in overweight/obese prediabetic subjects: a randomized controlled trial

Gitsomboon,

Ratanapornsompong,

Ongphiphadhanakul

et al. 2024

BMC Nutr

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Background Prediabetes is increasing worldwide. Previous studies have demonstrated the potential of β-glucan derived from oat or barley to lower blood glucose, body weight, and plasma lipid levels. These findings offer a potentially attractive strategy for reducing the risk of diabetes in prediabetic individuals. However, the effects of β-glucan from Tremella fuciformis on glucose metabolism and anthropometric measurements in humans have yet to be studied. We hypothesized that β-glucan from Tremella fuciformis may improve metabolic parameters in subjects with prediabetes. This study aimed to investigate the effects of a once-daily beverage containing Tremella fuciformis (snow mushroom) on anthropometric measurements, metabolic biomarkers, and insulin sensitivity in overweight/obese subjects with prediabetes. Methods In this double-blind RCT, 56 participants were randomly assigned to receive either a Tremella fuciformis beverage or placebo daily for 12 weeks. All parameters were assessed at baseline and after the intervention. Results After 12 weeks, participants in the intervention group exhibited significant improvements in glycated hemoglobin A1c (HbA1C; 6.03 ± 0.26% at baseline vs. 5.96 ± 0.25% at 12 weeks, p = 0.047, Cohen’s d = 0.39) and waist circumference (95.2 ± 12.51 cm at baseline vs. 93.46 ± 11.48 cm at 12 weeks, p = 0.022, Cohen’s d = 0.45). There were no adverse events reported. Conclusion This exploratory study demonstrated that Tremella fuciformis beverage consumption may improve HbA1C and waist circumference in overweight/obese prediabetic individuals. Further research, including larger-scale RCTs and mechanistic studies, is needed to confirm these findings and optimize the therapeutic potential of Tremella fuciformis derivatives in managing prediabetes and preventing type 2 diabetes. Trial registration Registered in Thai Clinical Trials Registry (14/07/2021, TCTR20210714004).

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Use of Polysaccharide extracted from Tremella fuciformis Berk for control diabetes induced in rats.

Cited by 12 publications

References 23 publications

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

A review on the production, structure, bioactivities and applications of Tremella polysaccharides

Tremella fuciformis beverage improves glycated hemoglobin A1c and waist circumference in overweight/obese prediabetic subjects: a randomized controlled trial

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