Use of polymer films in amperometric biosensors

Abstract

Different types of polymeric films implemented in various capacities in amperometric biosensor design are reviewed. Conducting and nonconducting polymer films and composite films are considered. Methods of film fabrication such as solvent casting, electropolymerization, and adsorption are presented. Film function, including prevention of interference and fouling problems, immobilization of the enzyme or active biocomponent, extension of linear range, or to address biocompatibility problems are described. The use of polymeric films as a medium to incorporate mediators, while an important function, is too vast for review here. The applications of polymer film-modified biosensors for selected analytical determinations are also presented. This review focuses upon the use of polymer films in amperometric biosensors and emphasizes innovative biosensor designs and unique applications, and omits traditional free-standing films unless they are coupled with new types of polymer films or used innovatively.

Electroanalytical chemistry for the analysis of solids: Characterization and classification (IUPAC Technical Report)

“…Reviews on conducting polymers [25][26][27] and nanocomposites with metal nanoparticles [7] and carbon nanotubes [28][29][30] are available.…”

Tendências em modificação de eletrodos amperométricos para aplicações eletroanalíticas

“…A adsorção consiste na dissolução do agente modificador em um solvente apropriado e na exposição, em geral por imersão, do eletrodo a esta solução 24,25 . Inicialmente, os trabalhos envolveram adsorção em eletrodos de platina porém, na maioria dos trabalhos subsequentes, as adsorções foram realizadas em eletrodos de grafite e carbono ví-treo 26 .…”

Cyclic Voltammetric, Chronocoulometric, and Spectroelectrochemical Studies of Electropolymerized Films Based on (3,4-Ethylenedioxythiophene)-Substituted 3,6-Dithiophen-2-yl-2,5-dihydropyrrole[3,4-c]pyrrole-1,4-dione

“…[1][2][3] The thiophene-based compound, 3,4-ethylenedioxythiophene (EDOT), forms organic conducting polymers with good mechanical stability, and excellent electronic and optical properties and has been the focus of studies for antistatic coatings, high storage capacitors, and drug delivery applications. [4][5][6] Important in any of these applications includes understanding the factors of electron transfer reactions between the polymer film and electrode, ion transport within polymer films, and possible polymer lattice motions or changes in polymer conformation on the electrode surface.…”