Use of polylactic acid/polytrimethylene carbonate blends membrane to prevent postoperative adhesions

Qin, Yuyue; Yuan, Minglong; Li, Lin; Guo, Siyuan; Yuan, Mingwei; Li, Wei; Xue, Jianming

doi:10.1002/jbm.b.30544

Cited by 33 publications

(15 citation statements)

References 77 publications

(105 reference statements)

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“…Therefore, PLA stents represented a promising future for the treatment of ureteral war injuries. Qin et al [75] used PLA based on polymer blends to prevent postoperative adhesions. In that study, PLA was blended with polytrimethylene carbonate (PTMC) using the solution method where the two polymers were mixed and dissolved in acetoacetate.…”

Section: Wound Managementmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

544

306

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Abstract. Polylactic acid (PLA), one of the well-known biodegradable polyesters, has been studied extensively for tissue engineering and drug delivery systems, and it was also used widely in human medicine. A new method to synthesize PLA (ring-opening polymerization), which allowed the economical production of a high molecular weight PLA polymer, broadened its applications, and this processing would be a potential substitute for petroleum-based products. This review described the principles of the polymerization reactions of PLA and, then, outlined the various materials properties affecting the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the processing technologies which were used to fabricate products based on PLA. In addition, the biodegradation processes of products which were shaped from PLA were discussed and reviewed. The potential applications of PLA in the medical fields, such as tissue engineering, wound management, drugs delivery, and orthopedic devices, were also highlighted.

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Section: Wound Managementmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

544

306

View full text Add to dashboard Cite

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“…In our previous study, we have tried to prepare PLA/PTMC blends with various blend ratios (PLA/ PTMC = 90/10, 80/20, 70/30, 60/40, and 50/50 (w/w)). PLA/PTMC (70/30) blend film, which appeared to be softer and more elastic than those with different blend ratios, was selected to use in this study [14,15].…”

Section: Introductionmentioning

confidence: 99%

Characterization of antimicrobial poly(lactic acid)/poly(trimethylene carbonate) films with cinnamaldehyde

2014

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Poly(lactic acid)/poly(trimethylene carbonate) (PLA/PTMC) films incorporated with cinnamaldehyde (0, 3, 6, 9, and 12 wt%) were prepared by solvent casting and characterized by physical, mechanical, and antimicrobial properties. SEM analysis revealed that the surface of film became rougher with certain porosity when cinnamaldehyde was incorporated into the PLA/PTMC blends. Cinnamaldehyde acted as plasticizers which reduce the intermolecular forces of polymer chains, thus improving the flexibility and extensibility of the films. Differential scanning calorimetry showed that the crystallinity of PLA phase decreased by the presence of cinnamaldehyde in the composite films. Water vapor permeability of films increased with the increase of cinnamaldehyde loading. However, the active PLA/PTMC/cinnamaldehyde composite films showed adequate barrier properties for food packaging application. Incorporation of cinnamaldehyde to the PLA/PTMC polymer matrix improved the antimicrobial activity of active packaging films. These results indicated that the best compromise between mechanical, barrier, thermal, and antimicrobial properties could be achieved by the addition of 9 wt% cinnamaldehyde into PLA/PTMC blends.

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“…In vivo studies using PTMC-based scaffolds have revealed the suitability of these materials for application in, for example, protein delivery systems [12] and the prevention of post-operative adhesions [13].…”

Section: Introductionmentioning

confidence: 99%