Use of Polyglycolic Acid Nerve Conduit (Neurotube) to Alleviate Pedicle Kinking in Microvascular Anastomosis

Holliday, Michael A.; Davison, Steven P.

doi:10.1097/01.prs.0000437233.23177.8b

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Furthermore, to the best of our knowledge, there was no evidence supporting the effectiveness of sutures in pedicle positioning. Fat graft, neurotube, and split vein graft are proposed to serve as a cushion or splint to prevent vascular kinking at the site of anastomosis (Agko et al, ; Holliday & Davison, ; Sader et al, ). However, it is difficult to stabilize the entire course of the pedicle.…”

Section: Discussionmentioning

confidence: 99%

The safety and benefit of using oxidized regenerated cellulose to position free flap pedicle in head and neck reconstruction

et al. 2019

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Background: Oxidized regenerated cellulose (ORC; Surgicel ® ; Ethicon, Neuchâtel, Switzerland) is an absorbable hemostatic agent used for hemostasis in operation, although some surgeons use it to position free flap pedicles. The increasing risk of vessel compromise is a huge concern. However, no scientific data to date demonstrate the safety and benefit of using ORC in microvascular surgery. In the present study, we compared the outcome of microvascular head and neck reconstruction with and without pedicle placement using ORC.patients undergoing microvascular surgery with free fibular osteocutaneous flap in our hospital. The patients were divided into the ORC group and non-ORC group and their baseline characteristics and outcomes were compared.Results: In total, there were 27 patients in the ORC group and 67 in the non-ORC group. The non-ORC group had significantly higher cigarette consumption (70.4% vs. 89.6%; p = .022). The outcome of the ORC group was better regarding arterial thrombosis (0% vs. 3%), flap failure (0% vs. 4.5%), hematoma (7.4% vs. 10.4%), and wound complications (25.9% vs. 44.8%). The ORC group had a worse result than the non-ORC group for vein thrombosis (7.4% vs. 4.5%) and duration of hospitalization (24.111 days vs. 23.627 days). However, none of above results was significant.Conclusions: Though this study was underpowered to detect the differences, the results showed a trend toward better outcomes of flaps and wounds in the ORC group. It seems that using ORC in this field is safe and beneficial.

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Section: Discussionmentioning

confidence: 99%

The safety and benefit of using oxidized regenerated cellulose to position free flap pedicle in head and neck reconstruction

et al. 2019

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“…The synthetic polymers and its mixtures with natural polymers serve suitable roles in bioprinting such nerve conduits. In particular, polyurethane, Polypyrrole (PPy)/Chitosan, poly (phosphoester) [ 65 , 66 ], collagen [ 67 , 68 ], polyglycolide [ 69 ], collagen and poly-glycolide [ 70 ], poly ( l -lactide-co-glycolide) (PLGA), poly- l -lactic acid/caprolactone and PCL/PPy Conductive Scaffolds [ 71 ] are among the most common polymers or mixtures used for this purpose. Nerves are electrophysiological organs; hence, nerve conduits with electrical conductivity would go a long way to help regain the complete functionality of nerves.…”

Section: Scaffold Materialsmentioning

confidence: 99%

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

Soman¹,

Vijayavenkataraman

2020

IJMS

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The peripheral nervous system controls the functions of sensation, movement and motor coordination of the body. Peripheral nerves can get damaged easily by trauma or neurodegenerative diseases. The injury can cause a devastating effect on the affected individual and his aides. Treatment modalities include anti-inflammatory medications, physiotherapy, surgery, nerve grafting and rehabilitation. 3D bioprinted peripheral nerve conduits serve as nerve grafts to fill the gaps of severed nerve bodies. The application of induced pluripotent stem cells, its derivatives and bioprinting are important techniques that come in handy while making living peripheral nerve conduits. The design of nerve conduits and bioprinting require comprehensive information on neural architecture, type of injury, neural supporting cells, scaffold materials to use, neural growth factors to add and to streamline the mechanical properties of the conduit. This paper gives a perspective on the factors to consider while bioprinting the peripheral nerve conduits.

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Use of Spongostan™ for pedicle stabilisation in head and neck microvascular reconstruction

2015

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Use of Polyglycolic Acid Nerve Conduit (Neurotube) to Alleviate Pedicle Kinking in Microvascular Anastomosis

Cited by 4 publications

References 3 publications

The safety and benefit of using oxidized regenerated cellulose to position free flap pedicle in head and neck reconstruction

The safety and benefit of using oxidized regenerated cellulose to position free flap pedicle in head and neck reconstruction

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

Use of Spongostan™ for pedicle stabilisation in head and neck microvascular reconstruction

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