Use of poly(ethylene oxide) gel in butadion ointment composition

Synthesis and Properties of a Star-Shaped Poly( ϵ -Caprolactone)–Ibuprofen Conjugate

“…Complexes and conjugates of IBU with various compounds, such as vinyl ether [39], co-polymers (poly(ε-caprolactone-co-D,L-lactide) [40], poly(methylmethacrylate)/sol-gel glass mixture, poly(ethylene oxide), β-cyclodextrin and phosphatidylcholine [41][42][43][44] have been previously obtained and their hydrolytic behavior and release profile were intensively studied. Moreover, hydrolyzable IBU derivatives, such as amides [45] or anhydrides [46], were also synthesized in order to improve biopharmaceutical properties of the drug.…”

Binding Characteristics between Poly(ethylene glycol) and Hydrophilic Modified Ibuprofen in Aqueous Solution

“…[4][5][6] A suspending liquid is made, and some stuffing is added to achieve slow release formulation in clinical practice; for example, a water-soluble polymer, poly(ethylene glycol) (PEG), is always used as a stabilizer in pharmaceuticals as a medicated premix. 7,8 And some research focuses on utilizing the hydrophobic core of surfactant aggregates to solubilize ibuprofen. 4,9 Nonionic surfactants, for example, polyoxyethylated surfactants, are the major type of surface active agents used in delivery systems since they are generally less toxic, less hemolytic, and less irritating to the afflicted part and tend to maintain physiological pH values in solution.…”

“…Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is widely used, because it produces fewer gastrointestinal adverse events. – However, the solubility of ibuprofen in water is poor, which affects pharmaceutical product development in nearly all therapeutic areas. At present, several methods are used to solve this problem. – A suspending liquid is made, and some stuffing is added to achieve slow release formulation in clinical practice; for example, a water-soluble polymer, poly(ethylene glycol) (PEG), is always used as a stabilizer in pharmaceuticals as a medicated premix. , And some research focuses on utilizing the hydrophobic core of surfactant aggregates to solubilize ibuprofen. , Nonionic surfactants, for example, polyoxyethylated surfactants, are the major type of surface active agents used in delivery systems since they are generally less toxic, less hemolytic, and less irritating to the afflicted part and tend to maintain physiological pH values in solution.…”