Use of Pleural Fluid C-Reactive Protein Level as a Diagnostic Marker for Pleural Effusions

Kapisyzi, Perlat; Argjiri, Dhimitraq; Byrazeri, Genc; Mitre, Anila; Beli, Jeta; Vakeflliu, Ylli; Kore, Roland; Shehu, Elenka; Light, Richard

doi:10.1378/chest.136.4_meetingabstracts.30s-f

Cited by 9 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same is true with empyema; due to its high NPV, a cut-off value below 2.31 can theoretically decrease the necessity of pleural drainage for complicated effusions. Our results are consistent with other studies that reported higher CRP levels in parapneumonic effusions among the exudative categories, which exhibit a range of cut-off values of 3 to 9 mg/dL [ 2 , 9 , 10 , 14 , 18 ]. The differences in the absolute cut-off values can be attributed to the different analysis methods used for measuring CRP.…”

Section: Discussionsupporting

confidence: 93%

“…This study corroborates and amplifies previous investigations. Pleural CRP levels are reportedly higher in parapneumonic effusions than in other types of exudates [ 2 , 14 , 18 ]. Evaluation of the pleural CRP levels is a useful test for differentiating between complicated and uncomplicated parapneumonic effusions [ 9 , 17 ] and between acute and chronic inflammation [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pleural CRP has recently been proposed as a specific biomarker for the differential diagnosis of pleural effusions and reportedly exhibits higher sensitivity and specificity than serum CRP [ 14 ]. CRP can be considered a good candidate due to its 1000-fold elevation in response to infection and the positive correlation between the serum and pleural CRP levels [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions

et al. 2016

View full text Add to dashboard Cite

Purpose. The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods. A single-center, retrospective review of 244 patients diagnosed with pleural effusions was initiated among patients at the Rabin Medical Center, Petah Tikva, Israel, between January 2011 and December 2013. The patients were categorized into 4 groups according to their type of pleural effusion as follows: heart failure, malignant, post-lung transplantation, and parapneumonic effusion. Results. The pleural CRP levels significantly differentiated the four groups (p < 0.001) with the following means: parapneumonic effusion, 5.38 ± 4.85 mg/dL; lung transplant, 2.77 ± 2.66 mg/dL; malignancy, 1.19 ± 1.51 mg/dL; and heart failure, 0.57 ± 0.81 mg/dL. The pleural fluid CRP cut-off value for differentiating among parapneumonic effusions and the other 3 groups was 1.38 mg/dL. The sensitivity, specificity, positive predictive value, and negative predictive value were 84.2%, 71.5%, 37%, and 95%, respectively. A backward logistic regression model selected CRP as the single predictor of parapneumonic effusion (OR = 1.59, 95% CI = 1.37–1.89). Conclusions. Pleural fluid CRP levels can be used to distinguish between parapneumonic effusions and other types of exudative effusions. CRP levels < 0.64 mg/dL are likely to indicate a pleural effusion from congestive heart failure, whereas levels ≥ 1.38 mg/dL are suggestive of an infectious etiology.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In similar studies the ADA cut off value are proposed as above 40 IU/L, 72 IU/L, 77.5 IU/L. [15][16][17] Even more are proposed studied with cut off 100 IU/L. 18 High levels of ADA are seen to be increase in different body conditions not related strictly with pleural effusion, in this way this marker might be considered with reserves as a very good options for the difference.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of diagnostic efficacy of interferon gamma and adenosine deaminase in exudative pleural effusion

Hakani

Mitre

2016

Int J Adv Med

Self Cite

View full text Add to dashboard Cite

Background: The aim of the study was to investigate the clinical utility of biomarkers, interferon gamma (INF-γ) and adenosine deaminase (ADA) in the differential diagnosis between tuberculosis and non-tuberculosis pleural effusion. Methods: The present study enrolled 130 patients with pleural effusion that were admitted to hospital between 2012-2015. From the patients were obtained pleural fluid and serum which were administrated to test analyses within 24 hours. Results: Based on Light's criteria, biochemical, cytological etc. analyses were established the pleural effusion as exudative and the etiology of the effusion, 40 malign, 48 tuberculosis, 42 parapneumonic. Pleural fluid, serum and pleural fluid/serum ADA and INF-γ pleural fluid results differ significantly between the different types of exudative effusion. For the difference of tuberculosis and non-tuberculosis pleural effusion ADA pleural fluid, ADA serum and INF-γ pleural fluid showed significance for this difference, meanwhile ADA pleural fluid/serum do not contribute in the difference. Conclusions: The study conducted that ADA and INF-γ markers can be used for the differential diagnosis of exudative pleural effusion and tuberculosis from non-tuberculosis. INF-γ even if it has a higher specificity than ADA, due to its cost we recommend that it cannot be promoted as the only solution that facilitate the different diagnosis, other markers need to be taken into consideration to assist the results.

show abstract

“…The pleural fluid CRP > than 20 mg/L virtually exclude transudative nature of pleural effusion (16,17).…”

Section: Acute Inflammation Biomarkers In Pleural Effusionsmentioning

confidence: 99%

Acute Inflammation Biomarkers in Pleural

Kapisyzi¹,

Dikensoy²,

Argjiri³

2012

Plev Bult

Self Cite

View full text Add to dashboard Cite

Use of Pleural Fluid C-Reactive Protein Level as a Diagnostic Marker for Pleural Effusions

Cited by 9 publications

References 1 publication

The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions

The Diagnostic Value of the Pleural Fluid C-Reactive Protein in Parapneumonic Effusions

A clinical study of diagnostic efficacy of interferon gamma and adenosine deaminase in exudative pleural effusion

Acute Inflammation Biomarkers in Pleural

Contact Info

Product

Resources

About