Use of platelet-rich plasma, platelet-rich growth factor with arthrocentesis or arthroscopy to treat temporomandibular joint osteoarthritis

Haigler, Mary Charles; Abdulrehman, Einas; Siddappa, Savitha; Kishore, Rekha; Padilla, Mariela; Enciso, Reyes

doi:10.1016/j.adaj.2018.07.025

Cited by 50 publications

(61 citation statements)

References 26 publications

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“…There is some evidence showing that PRGF can act as a protector. Several authors have demonstrated the benefits of using PRGF for wound healing and inflammation in ocular surface pathologies [28,32,33,35,36,51,52]. This research group, therefore, wanted to test whether it could act as a neuroprotective agent on RPE cells.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Suárez-Barrio

Olmo-Aguado

García-Pérez

et al. 2020

IJMS

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Oxidative stress has a strong impact on the development of retinal diseases such as age-related macular degeneration (AMD). Plasma rich in growth factors (PRGF) is a novel therapeutic approach in ophthalmological pathologies. The aim of this study was to analyze the antioxidant effect of PRGF in retinal epithelial cells (EPR) in in vitro and ex vivo retinal phototoxicity models. In vitro analyses were performed on ARPE19 human cell line. Viability and mitochondrial status were assessed in order to test the primary effects of PRGF. GSH level, and protein and gene expression of the main antioxidant pathway (Keap1, Nrf2, GCL, HO-1, and NQO1) were also studied. Ex vivo analyses were performed on rat RPE, and HO-1 and Nrf2 gene and protein expression were evaluated. The results show that PRGF reduces light insult by stimulating the cell response against oxidative damage and modulates the antioxidant pathway. We conclude that PRGF’s protective effect could prove useful as a new therapy for treating neurodegenerative disorders such as AMD.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Suárez-Barrio

Olmo-Aguado

García-Pérez

et al. 2020

IJMS

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“…In this context, arthrocentesis is thought to improve outcomes of TMDs by flushing out inflammatory mediators and reducing the joint vacuum thereby improving the lubrication of the joint 26 . To supplement the efficacy of the procedure, clinicians have also injected several drugs at the end of TMJ arthrocentesis like corticosteroids, sodium hyaluronate, platelet‐rich plasma, and analgesics 5‐7 . A meta‐analysis of RCTs by Liu et al 7 has demonstrated that intra‐articular corticosteroids injected post‐arthrocentesis has no effect on pain and MMO at short‐term follow‐up.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the use of intra‐articular drugs after arthrocentesis has gained popularity in the past decade. Several clinical trials have attempted to improve the efficacy of TMJ arthrocentesis by injecting corticosteroids, sodium hyaluronate, platelet‐rich plasma, etc into the joint space 5‐7 . Experience from arthroscopy procedures on knee joints has demonstrated that intra‐articular analgesics may be injected at the end of the procedure to provide early pain relief 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…Several clinical trials have attempted to improve the efficacy of TMJ arthrocentesis by injecting corticosteroids, sodium hyaluronate, platelet-rich plasma, etc into the joint space. [5][6][7] Experience from arthroscopy procedures on knee joints has demonstrated that intra-articular analgesics may be injected at the end of the procedure to provide early pain relief. 8,9 Inspired by these trials, several clinicians have also experimented with the use of intra-articular analgesics after TMJ arthrocentesis.…”

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confidence: 99%

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Do intra‐articular injections of analgesics improve outcomes after temporomandibular joint arthrocentesis?: A systematic review and meta‐analysis

Liu

Zhang

2020

J of Oral Rehabilitation

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Since its first description by Nitzan et al in 1991, 1 arthrocentesis of the temporomandibular joint (TMJ) has become a routine procedure for the management of temporomandibular joint disorders (TMDs). The procedure has been used for anchored disk phenomenon, closed lock, anterior disc displacement with/without reduction and osteoarthritis. 2 It has gained wide popularity worldwide owing to its simple, inexpensive and minimally invasive nature. 2 Clinicians usually employ arthrocentesis in patients not responding to conservative therapies like painkillers, occlusal splints and physical therapy. 3

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“…Steroidal and non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, sodium hyaluronate or more recently described platelet-rich growth factor are some of the substances that have been injected in the TMJ in the aim to decrease pain and inflammation (Guilherme et al, 2019;Haigler et al, 2018;Moldez, Camones, Ramos, Padilla, & Enciso, 2018).…”

Section: Introductionmentioning

confidence: 99%

Electroporation technique for joint pain – Pilot feasibility study on TMD patients

Tartaglia

Gizdulich²,

Farronato

et al. 2020

Clinical & Exp Dental Res

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Objective(s) It is well appreciated that traditional analgesic delivery routes used to treat pain associated with temporomandibular disorder (TMD) often have harmful unintended side effects as a consequence of systemic distribution. Further, localized delivery of analgesic medication via intra‐articular injections involves a different set of issues limiting their clinical viability. As an option, transdermal analgesic delivery provides for prolonged pain relief and flexibility in dose administration, while limiting systemic exposure and minimizing adverse events. Incorporation of a novel electroporation technique may further increase transdermal drug penetration into synovial tissue/fluid and enhance pain reduction. The present feasibility study compares the effectiveness of an electroporation‐enhanced transdermal application of diclofenac sodium to a conventional intra‐articular injection of triamcinolone acetonide suspension (corticosteroids) to treat patients with TMD associated pain. Methods Pre‐ and post‐treatment maximal incisal mouth opening (MIO), pain visual analog scale (VAS) and surface electromyography (EMG) of 22 patients treated with electroporation‐enhanced diclofenac and 37 patients treated with corticosteroids injections were collected and analyzed. Results In general, patients treated with electroporation exhibited better results in terms of pain improvement (corrected p‐value = .01) compared to the standard treatment, but both methods were similarly effective for improvement of MIO (corrected p‐value = .71) and improvement of all EMG indices (corrected p‐values ≥ .05). Conclusion The enhancing effect of electroporation in transdermal delivery of diclofenac sodium was demonstrated by decreased pain, increase MIO and EMG improvement to normal values. Its analgesic and inflammatory results are comparable with standard treatment offered by corticosteroids.

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Use of platelet-rich plasma, platelet-rich growth factor with arthrocentesis or arthroscopy to treat temporomandibular joint osteoarthritis

Cited by 50 publications

References 26 publications

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases

Do intra‐articular injections of analgesics improve outcomes after temporomandibular joint arthrocentesis?: A systematic review and meta‐analysis

Electroporation technique for joint pain – Pilot feasibility study on TMD patients

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