Use of platelet-rich fibrin over skin wounds: Modified secondary intention healing

Abstract

The healing process after any surgical intervention has always posed a challenge for the surgeons. In spite of the advances in wound closure techniques and devices, there is a crucial need for newer methods of enhancing the healing process to achieve optimal outcomes. Fibrin adhesives and platelet concentrates have proven useful in various treatment modalities in the fields of microvascular and plastic surgery. This case report shows its unique use in the field of maxillofacial and cutaneous surgery. It shows an innovative technique of enhancement of skin wound healing by local application of platelet-rich fibrin.

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

“…The PRF is an evolution of platelet-rich aggregates, intended to utilize the positive effect of platelet-derived growth factors on tissue healing and regeneration. [34][35][36] It differs from other platelet-rich concentrates such as PRP and PRGF in two key aspects. First, PRF is a total autologous, unaltered platelet-based aggregate that requires no additives to anti-coagulate the blood or activate the platelets.…”

Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation

“…In the clinical setting, autologous PRF has the added advantages of preventing immunologic rejection, simple production, and few complications. The beneficial effects of PRF in damage repair and tissue regeneration have been widely reported [ 39 – 40 ]. Here, we treated 62 patients with facial depression deformities by transplanting a mixture of newly-isolated nanofat, which is rich in SVF, PRF, and autologous fat compared to a control group including 77 patients treated with the traditional autologous fat graft.…”

Biological and Mechanical Properties of Platelet-Rich Fibrin Membranes after Thermal Manipulation and Preparation in a Single-Syringe Closed System

“…Furthermore PRF increases new bone formation and has a positive effect on early bone healing [ 30 , 31 ]. PRF is also suitable to facilitate meniscal repair by promoting meniscocytes proliferation [ 32 ], and dermal fibroblast migration during the remodeling of the skin [ 33 , 34 , 35 ]. Li Q et al [ 36 ] compared the effects of fresh and lyophilized PRF on dental follicle, periodontal ligament and alveolar bone cells.…”