Use of Platelet Rich Fibrin in Facial Aesthetics and Rejuvenation

Nacopoulos, Cleopatra

doi:10.1002/9781119406792.ch13

Cited by 4 publications

(7 citation statements)

References 29 publications

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“…26 Limited data have been reported for its use in aesthetic skin rejuvenation. 27,28 Here, we report the results of a study that prospectively evaluated the efficacy and safety of i-PRF for use in facial rejuvenation using an objective skin analysis system and a validated patient-reported outcome measure.…”

Section: Introductionmentioning

confidence: 99%

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Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Hassan

Quinlan

Ghanem

2020

J of Cosmetic Dermatology

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Section: Introductionmentioning

confidence: 99%

“…Use of this injectable form of PRF has been reported for the treatment of various oral and maxillofacial procedures 24,25 and alopecia 26 . Limited data have been reported for its use in aesthetic skin rejuvenation 27,28 …”

Section: Introductionmentioning

confidence: 99%

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Hassan

Quinlan

Ghanem

2020

J of Cosmetic Dermatology

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“…The Telomere hypothesis links cellular ageing to fibroblast telomere loss [8,9]. Aesthetic practices often fall short [10]. Platelet concentrates with abundant growth factors aids tissue repair and rejuvenation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics

Brodt,

Garcia,

Costa

et al. 2023

JAMMR

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Introduction: Cutaneous ageing, an inherent process with advancing time, often detrimentally impacts self-esteem due to manifestations like wrinkles, blemishes, dehydration, sagging, and reduced tissue vitality. A contemporary trend seeks natural approaches to facial rejuvenation. Injectable Platelet-Rich Fibrin (i-PRF) emerges as a noteworthy solution owing to its biological origin and autologous nature. Materials and Methods: Evaluating i-PRF's efficacy in counteracting ageing signs, we employed a 16 MHz high-frequency ultrasound device and meticulous photographic documentation. 26 females, aged 35-55, underwent three i-PRF sessions. Statistical scrutiny utilised a paired t-test (α = 0.05) to assess dermal modifications. Self-Perception Index scores underwent Wilcoxon testing (α = 0.05) for significant enhancements. Comparisons of newly captured frontal and profile photographs (D and E) with initial images aided visible change assessment. Results and Discussion: Compelling data analysis evidenced a notable dermal thickness increase post-intradermal i-PRF application. P-values for examined regions were: glabella (P < .00269), frontal D (P < .00018), frontal E (P < .00014), cheek D (P < .00709), and cheek E (P < .0008). These results underscore substantial dermal thickness alterations. Statistical examination of the Self-Perception Index yielded a P-value < .0001, signifying significant self-perception change post-treatment. Conclusion: Intradermal i-PRF application markedly increased dermal thickness, endorsing its potential for dermal restructuring. Furthermore, this approach presents an accessible, cost-effective, and unbiased alternative for facial rejuvenation.

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“…Additional refinements to this preparation were made in 2018 resulting in a second‐generation i‐PRF product, known as i‐PRF+, that contains an increased number of platelets and mesenchymal stem cells. The last few years have seen a growing body of evidence supporting use of i‐PRF for various applications within dentistry, oral surgery, dermatology, and facial aesthetics 15–20 . However, clinical evidence supporting the use of i‐PRF (and i‐PRF+) in facial aesthetics, especially in the perioral area and the lips, is limited.…”

Section: Introductionmentioning

confidence: 99%

Injectable platelet‐rich fibrin for perioral rejuvenation as assessed by 3D lip volume imaging

Hamid

Quinlan

Seemann

et al. 2021

J of Cosmetic Dermatology

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Background Various injectable autologous platelet aggregate preparations have been developed and used for facial rejuvenation. Limited evidence exists for the use of these for augmentation of the lip. Objectives This prospective, uncontrolled, single‐center study evaluated the qualitative and quantitative effects of an injectable platelet‐rich fibrin preparation (known as i‐PRF+) for lip augmentation. Patients/methods PRF® PROCESS system technology was used to prepare i‐PRF+ supernatant. Ten healthy females were included in the study and received a single intradermal injection of i‐PRF+ in the upper and lower lips (5 ml in each quadrant, total ~2 ml). Participants were followed for 3 months post‐procedure. The efficacy of the procedure was assessed qualitatively by a subjective patient‐reported outcome (FACE‐Q) assessment and quantitatively by objective 3D skin surface volume analysis (ProFace®) at baseline and after 3 months. Results FACE‐Q scales that measure satisfaction with skin and lip showed a statistically significant improvement from baseline (p = 0.04 and p = 0.02, respectively). Satisfaction with lip lines showed a numerical improvement with mean total scores for adverse effect scales related to the skin and lips reduced at 2 weeks post‐procedure (p = 0.03 and p = 0.13, respectively). Overall lip volume at 3‐month follow‐up was unchanged (p = 0.11). The treatment was well tolerated with only minor adverse effects. Conclusions A single session of i‐PRF+ injections resulted in significant lip rejuvenation at 3‐month follow‐up, shown by improved patient‐reported outcome measure. No significant change in lip volume was observed.

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Use of Platelet Rich Fibrin in Facial Aesthetics and Rejuvenation

Cited by 4 publications

References 29 publications

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study

Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics

Injectable platelet‐rich fibrin for perioral rejuvenation as assessed by 3D lip volume imaging

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