Use of phytotherapy in treating diabetic foot in older adults: an integrative review

Pires, José Mateus; Lopes, Gabriella Farias; Sousa, Caroline Ribeiro de; Oliveira, Francisco Gerlai Lima; Souza, Rodrigo Lopes de Paula; Coutinho, Janaína Fonseca Victor; Marques, Marília Braga

doi:10.15253/2175-6783.20232485110

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…19 , 20 Also, a wide range of literature supports utilizing herbal treatments to improve DFU; however, further high‐quality appraisals on the efficacy and safety of these interventions are recommended before they can be applied on a large scale. 21 , 22 , 23 , 24 , 25 , 26 Systematic reviews, which are at the top of the clinical evidence hierarchy, have recently addressed the potential effect of herbal products in healing DFU; however, they either focused on metabolites and phytoconstituents of used herbs or synthesized the results of investigations with different study designs, making it difficult to draw a reliable conclusion. 27 , 28 , 29 , 30 On the contrary, reviews that performed a meta‐analysis or comprehensive synthesis included only studies conducted in China or evaluated Chinese Herbal Medicines (CHM), which may limit the generalizability and applicability of their findings.…”

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confidence: 99%

Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Zamanifard,

Nasiri,

Yarahmadi

et al. 2024

International Wound Journal

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This systematic review aimed to qualitatively synthesize recent randomized controlled trials (RCTs) regarding the effect of topical application and oral intake of herbal products on the healing of diabetic foot ulcer (DFU). Also, we sought to pool the obtained findings in a meta‐analysis using a random‐effects model, if RCTs were relatively comparable and homogenous. A comprehensive search was performed on five electronic data sources from their inception through 23 January 2024. The RCTs, without restriction on the country of origin, were included if they compared the effect of administering standard treatments and/or placebo (i.e. control condition) to applying standard treatments and/or herbal products in topical or oral routes (i.e. experimental condition). Out of 1166 retrieved records, 28 RCTs were included. Studies used different poly and single herbal formulations. Based on the meta‐analysis, administration of standard care plus daily dressing of the ulcer site with olive oil for 28 days significantly increased the total ulcer healing score (3 RCTs; weighted mean difference [WMD] = 89.30; p < 0.001), raised frequency of complete ulcer healing (2 RCTs; risk ratio [RR] = 12.44; p = 0.039) and declined ulcer degree (3 RCTs; WMD = −22.28; p = 0.002). Also, daily use of the bitter melon leaf extract in oral form for 28 days significantly increased the total ulcer healing score (2 RCTs; WMD = 0.40; p = 0.001). Additionally, based on qualitative synthesis, the adjuvant use of herbal agents seems an intriguing choice to manage DFU. Nonetheless, considering the undesirable methodological quality of most studies and the high heterogeneity in administered herbal formulations, more robust trials are required to build a solid conclusion regarding the use of herbal products for healing DFU.

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