Use of Physical Forces in Bone Healing

Nelson, Fred R.T.; Brighton, Carl T.; Ryaby, James T.; Simon, Bruce J.; Nielson, Jason H.; Lorich, Dean G.; Bolander, Mark E.; Seelig, J. M.

doi:10.5435/00124635-200309000-00007

Cited by 108 publications

(75 citation statements)

References 50 publications

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“…An effective strategy for improving or sustaining mechanotransduction is magnetic actuation (see Glossary), which has been available for nearly three decades in the form of FDA-approved pulsed electromagnetic field (PEMF) therapy [18]. Owing to recent progress in nanomedicine and molecular biology, we can begin to understand the signalling pathways involved in mechanotransduction and exploit them with magnetic actuation for a myriad of applications: stem cell differentiation and homing to injury sites, as well as tissue engineering strategies [19][20][21][22][23][24][25].…”

mentioning

confidence: 99%

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Santos¹,

Reis²,

Gomes³

2015

Trends in Biotechnology

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mentioning

confidence: 99%

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Santos¹,

Reis²,

Gomes³

2015

Trends in Biotechnology

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“…Physical forces applied in bone create electrical potential signaling cellular changes that enhance healing; these forces can be mechanical, electrical or sonic. [17].…”

Section: Discussionmentioning

confidence: 99%

Pulsed Electromagnetic Field and Extracorporeal Shock Wave in Treatment of Delayed or Non-United Tibial Fracture, A Comparative Study

Nada¹,

Ashkar²,

Abdel-Ghany³

et al. 2017

Int J Phys Med Rehabil

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Objectives: To compare the effect of pulsed electromagnetic field (PEMF) extracorporeal shock wave therapy (ESWT) on healing of delayed as well as non-united tibial fractures. Methods:This study was carried out on 60 adult patients suffering from delayed or non-union tibial fractures in spite of previous conservative treatment by (closed reduction and casting), or operative treatment by: ORIF by (IMN, plate and screws or gliding nail), or external fixation. They were divided according to line of treatment into 2 equal groups. The first group received (PEMF) therapy at the site of fracture of 12 Hz, 3 mT for 60 minutes per session, for 3 months, the patient of the second group were treated by focused (ESWT) at the site of fracture 3 sessions of 2500-3000 impulses each given at 0.25-0.84 mJ/mm 2 , at interval of 48-72 h between sessions, a maximum of 3 cycles of treatment was given at 3 months intervals. Clinical and radiological assessments were done before, after and then 6 months later as follow up. However functional assessment was done after treatment and 6 months later as follow up. Results:Our results showed better and earlier improvement of clinical, radiological as well as functional scores in group II more than group I. Conclusion:The best significant as well as more rapid clinical, radiological and functional improvement in cases of delayed or non-united tibial fractures was obtained with ESWT compared to PEMF therapy.

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“…Literatürde hem bu faktörlerle ilgili, hem de farklı enerji türleri ve elektromanyetik alan (EMA) uygulamaları gibi fi ziksel faktörlerin kırık iyileşmesi üzerine etkileriyle ilgili çeşitli biyolojik sistemlerde yapılmış çok sayıda çalışmaya rastlamak mümkündür 8,9 . Kırık iyileş-mesine etki eden faktörlerle ilgili olarak; kırık hematomunun ve periostun korunmasının iyileşmeyi olumlu etkilediği 1,3 belirtilmesine rağmen nikotinin ve nonsteroid antienfl amatuvar ilaçların kırık iyileşmesini olumsuz etkilediği bildirilmektedir 10,11 .…”

Section: Kırık Iyileșmesini Etkileyen Faktörlerunclassified

The effects of low and high frequency electromagnetic fields on fracture healing

Aslan¹

2012

Kafkas J Med Sci

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Kırık iyileșmesiVücuttaki onarım olayları içerisinde, skar dokusu ile sonlanmadan, gerçeğe en yakın biçimde yeniden yapılanma ile karakterize olan yara iyileşmesi kırık iyileşmesidir. Kırık iyileşmesi; dayanıklılığı, oluşumu, yenilenmesi ve yapılanması çok sayıda genel ve yerel düzenleyicilere bağlı olan, hücresel yapıların karşılıklı etkileşimini içeren karmaşık bir süreçtir. Hematomenfl amasyon, yumuşak kallus, sert kallus ve yeniden şekillenme evrelerinden oluşur (Şekil-1). Bu süreç ve evreler şimdiye kadar iyi tanımlanmakla birlikte hala aydınlatılmayı bekleyen noktalar vardır. Diğer yandan kırık iyileşmesini olumlu ya da olumsuz etkileyen genel ve yerel etkenlerle ilgili birçok çalışma yapılmasına rağmen patofi zyolojisi ve etkileyen faktörlerin mekanizması hala tam aydınlatılamamıştır. Kırık iyileşme-sinde etkili faktörler, iyileşmenin uyarılması ve en iyi tedavi konusunda arayışlar devam etmektedir [1][2][3][4][5][6][7] . Kırık iyileșmesini etkileyen faktörlerKırık iyileşmesi üzerine olumlu ya da olumsuz etkisi olan genel ve yerel faktörler Tablo-1 de gösterilmiş-tir. Literatürde hem bu faktörlerle ilgili, hem de farklı enerji türleri ve elektromanyetik alan (EMA) uygulamaları gibi fi ziksel faktörlerin kırık iyileşmesi üzerine etkileriyle ilgili çeşitli biyolojik sistemlerde yapılmış çok

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Use of Physical Forces in Bone Healing

Cited by 108 publications

References 50 publications

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Pulsed Electromagnetic Field and Extracorporeal Shock Wave in Treatment of Delayed or Non-United Tibial Fracture, A Comparative Study

The effects of low and high frequency electromagnetic fields on fracture healing

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