Use of Photobiomodulation to Reduce Postoperative Pain, Edema, and Trismus After Third Molar Surgery: A Systematic Review and Meta-Analysis

Lacerda-Santos, Jhonatan Thiago; Granja, Gélica Lima; Firmino, Ramon Targino; Freitas-Dias, Ricardo; Melo, Daniela Pita de; Granville-Garcia, Ana Flávia; Martins, Carolina Castro

doi:10.1016/j.joms.2023.05.007

Cited by 6 publications

(11 citation statements)

References 50 publications

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“…Low-power lasers have been widely used for the treatment of various conditions because they can induce the photobiomodulation effect in biological tissues. Therapeutic protocols based on photobiomodulation are available and used successfully for reducing/accelerating inflammatory processes [2,3], reducing pain [4,5], promoting wound healing [6,7], and treating muscle and nerve injuries [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

da Cunha Sales,

de Pontes dos Santos,

da Silva Ferreira

et al. 2024

Laser Phys.

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Laser devices are light sources that emit monochromatic, coherent, and collimated electromagnetic radiation beams. Low-power lasers are widely used to treat clinical conditions based on the photobiomodulation effect. Despite therapeutic applications, mainly in continuous waves, limited data are available on photobiomodulation effects induced by low-power lasers in the pulsed emission mode. Thus, the aim of this study was to evaluate the effects of a low-power pulsed infrared laser on survival, proliferation, DNA damage, and reactive oxygen species (ROS) levels in Escherichia coli cells. E. coli C600 cultures and pUC19 plasmids were exposed to a low-power pulsed (5000 Hz) infrared (904 nm) laser (1.1, 2.3, and 4.6 J). Bacterial survival was evaluated by survival fractions, bacterial proliferation was evaluated by measurement of bacterial colony areas, DNA damage was evaluated by plasmid profiling in agarose gels after electrophoresis, and ROS level was evaluated by flow cytometry. The results suggest that exposure to a low-power infrared laser in pulsed emission mode does not alter the proliferation of E. coli C600 and the electrophoretic profile of bacterial plasmids but decreases survival and increases ROS levels in E. coli C600 cultures.

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Section: Introductionmentioning

confidence: 99%

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

da Cunha Sales,

de Pontes dos Santos,

da Silva Ferreira

et al. 2024

Laser Phys.

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“…PBM has been widely investigated as an adjunctive modality to the surgical procedure of the extraction of the impacted third molar [11,18,19]. Several meta-analyses and systematic reviews have been conducted in recent years to evaluate the effectiveness of the PBM and determine the best effective protocols [20][21][22][23][24]. In the literature, it appears that the level of the effectiveness of PBM has grown through the years with the performance of studies, as Brignardello-Petersen et al in 2012 and then Dawdy et al in 2017 did not observe any positive effect of PBM with third molar surgery [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Lacerda-Santos et al reported, in 2023, the effectiveness of PBM for the reduction in all pain, swelling, and trismus. However, they found that PBM's level of evidence still ranges from low to very low in a way meaning that PBM cannot be considered a routine practice with third molar surgery [24]. They recommended using the combined protocols of PBM (intraoral and extraoral) rather than only the intraoral or extraoral protocol [24].…”

Section: Introductionmentioning

confidence: 99%

“…However, they found that PBM's level of evidence still ranges from low to very low in a way meaning that PBM cannot be considered a routine practice with third molar surgery [24]. They recommended using the combined protocols of PBM (intraoral and extraoral) rather than only the intraoral or extraoral protocol [24]. Most of the wavelengths used for PBM in the studies included in these systematic reviews were red and near-infrared wavelengths [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…They recommended using the combined protocols of PBM (intraoral and extraoral) rather than only the intraoral or extraoral protocol [24]. Most of the wavelengths used for PBM in the studies included in these systematic reviews were red and near-infrared wavelengths [20][21][22][23][24]. All of these systematic reviews recommended conducting further studies in order to determine the effective PBM protocols [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Single-Session Intraoral and Extraoral Photobiomodulation on Pain Control after Extraction of Impacted Mandibular Third Molar: A Pilot Study

Tenore,

Mohsen,

Pergolini

et al. 2024

Applied Sciences

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This study aims to evaluate the impact of a single session of intraoral and extraoral photobiomodulation (PBM) on controlling pain and improving a patient’s daily activities following surgical extraction of the impacted mandibular third molar, using combined three wavelengths: “445 nm, 660 nm, and 970 nm”. A pilot study was conducted on 22 patients undergoing extraction of an impacted mandibular third molar. The patients were randomly divided into two groups: (1) The Test Group consisted of patients subjected to immediate postoperative PBM. The extraoral PBM parameters were power = 550 mW and spot area = 5 cm2, while the intraoral parameters were power = 200 mW and spot area = 2 cm2. (2) The Control Group consisted of the patients not subjected to PBM. For all the patients, the pain was evaluated via a Numeric Rating Scale (NRS) on day 0, day 1, day 3, and day 7 after surgical intervention. The patient’s daily activities were evaluated on day 7 via a custom-made questionnaire. A statistically significant difference was observed between groups in the pain NRS scores on day 0 (p = 0.022), day 1 (p = 0.047), and day 7 (p = 0.028). No significant difference was found on day 3 (p = 0.153). A marginal statistical significance was observed with the number of painkillers taken (p = 0.054). No significant difference was observed with the questionnaire score (p = 0.206). This pilot study showed a significant reduction in postoperative pain on days 0, 1, and 7 with a single session of intraoral and extraoral PBM. However, the number of painkillers taken and the scores of the daily activities questionnaire did not show statistical significance despite the observed better results in patients subjected to PBM.

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Comparison of different dual-wavelength photobiomodulation protocols application in third molar extractions. A split-mouth randomized controlled trial

Pereira,

Bonatto,

Santos

et al. 2024

Photodiagnosis and Photodynamic Therapy

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Use of Photobiomodulation to Reduce Postoperative Pain, Edema, and Trismus After Third Molar Surgery: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 50 publications

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

Impact of Single-Session Intraoral and Extraoral Photobiomodulation on Pain Control after Extraction of Impacted Mandibular Third Molar: A Pilot Study

Comparison of different dual-wavelength photobiomodulation protocols application in third molar extractions. A split-mouth randomized controlled trial

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