Use of PET probe in surgical oncology

Molina, Manuel A.; Avisar, Eli

doi:10.1002/jso.20947

Cited by 2 publications

(1 citation statement)

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“…Not only the gamma-emitting pharmaceuticals, but also positron-emitting pharmaceuticals such as 18 F-FDG have been used for RGS, referred to as FDG-guided or FDG-directed surgery (Cohn et al 2008, Povoski et al 2008, Molina et al 2009, Kim et al 2011, James and Gambhir 2012. In the most common types of malignant tumor, FDG accumulate in tumor cell is increased with their malignancy.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery

et al. 2016

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As well as pre-operative roadmapping by (18)F-Fluoro-2-deoxy-2-D-glucose (FDG) positron emission tomography, intra-operative localization of the tracer is important to identify local margins for less-invasive surgery, especially FDG-guided surgery. The objective of this paper is to develop a laparoscopic Compton camera and system aimed at use for intra-operative FDG imaging for accurate and less-invasive dissections. The laparoscopic Compton camera consists of four layers of a 12-pixel cross-shaped array of GFAG crystals ([Formula: see text] mm(3)) and through silicon via multi-pixel photon counters and dedicated individual readout electronics based on a dynamic time-over-threshold method. Experimental results yielded a spatial resolution of 4 mm (FWHM) for a 10 mm working distance and an absolute detection efficiency of 0.11 cps kBq(-1), corresponding to an intrinsic detection efficiency of ∼0.18%. In an experiment using a NEMA-like well-shaped FDG phantom, a [Formula: see text] mm cylindrical hot spot was clearly obtained even in the presence of a background distribution surrounding the Compton camera and the hot spot. We successfully obtained reconstructed images of a resected lymph node and primary tumor ex vivo after FDG administration to a patient having esophageal cancer. These performance characteristics indicate a new possibility of FDG-directed surgery by using a Compton camera intra-operatively.

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Section: Introductionmentioning

confidence: 99%

Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery

et al. 2016

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Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers

Campbell

Poon

Markel

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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Use of PET probe in surgical oncology

Cited by 2 publications

References 5 publications

Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery

Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery

Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers

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Use of PET probe in surgical oncology

Cited by 2 publications

References 5 publications

Development of a novel handheld intra-operative laparoscopic Compton camera for18F-Fluoro-2-deoxy-2-D-glucose-guided surgery

Development of a novel handheld intra-operative laparoscopic Compton camera for18F-Fluoro-2-deoxy-2-D-glucose-guided surgery

Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers

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Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery

Development of a novel handheld intra-operative laparoscopic Compton camera for¹⁸F-Fluoro-2-deoxy-2-D-glucose-guided surgery