Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil

Liguoro, Marco De; Cibin, Veronica; Capolongo, Francesca; Halling-Sørensen, Bent; Montesissa, Clara

doi:10.1016/s0045-6535(03)00284-4

Cited by 278 publications

(152 citation statements)

References 19 publications

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“…) (De Liguoro et al, 2003), which is consistent with the EMEA model trigger for surface water exposure. In an US investigation, 31% of the water samples proximal to swine farms and 67% of the samples proximal to poultry farms were found to contain antimicrobial compounds used in these farms: chlor-, oxy-and tetracycline, sarafloxacin, lincomycin and sulfadimethoxine, generally at levels < 4 g l −1 (Campagnolo et al, 2002).…”

Section: Functional Validation For Surface Watersupporting

confidence: 87%

“…Screening level models do not intend to represent reality accurately, but to provide rapid predictions of the potential environmental fate of a compound (Tarazona et al, 2003). To validate this claim, the available screening models are compared in Section 2 to field data published in literature for soil, surface water and groundwater (Hamscher et al, 2000, Hamscher et al, 2002, Winckler and Grafe, 2001b, Boxall et al, 2002, Schlüsener et al, 2003, Aga et al, 2003and De Liguoro et al, 2003.…”

Section: Introductionmentioning

confidence: 99%

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Validation of the exposure assessment for veterinary medicinal products

Montforts

2006

Science of The Total Environment

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Under the EU Directive 2004/28/EC, an environmental risk assessment of new veterinary medicinal products is required. Given the nature of risk assessment for new applications, there is a need to model exposure concentrations. Critical evaluations are essential to ensure that the use of models by regulators does not result in the propagation of misleading information. The empirical validations of soil exposure models, previously discussed in this journal, indicate that it is impossible to analyse the contribution of every model parameter to the variability in the predictions. In particular, the prediction of the slurry concentration is challenged by uncertainties concerning dilution, mixing and dissipation of residues. Surface water and groundwater models generated highly deviating results compared to the field results, questioning the usefulness of the available screening models. Animal husbandry, slurry handling and environmental conditions throughout Europe are considered in order to define realistic worst case scenarios, to be used in conjunction with distribution models for the environmental risk assessment of veterinary medicinal products at registration. Given the variability in manure management practice throughout Europe, a deterministic approach for the manure-to-soil model was selected. Both worst case and best case scenario were developed. Several modelling assumptions applied in the surface water exposure model for fish nursery effluent were validated against newly available data. Since the available data give no proof that a settling tank contributes to the removal of pesticides from waste water, it is recommended for risk assessment purposes to consider the contribution of the settling tank to removal of pesticides and medicines to be negligible. Surface water dilution factors may be considered to be rather small, a factor of 2, for low flow situations.

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Section: Functional Validation For Surface Watersupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Validation of the exposure assessment for veterinary medicinal products

Montforts

2006

Science of The Total Environment

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“…Previous studies have demonstrated that antibiotics in soils can contribute significantly to the contamination of water bodies and sediments (Kay et al, 2005). Veterinary antibiotics enter the soil mainly through the application of animal manure (Loke et al, 2002;De Liguoro et al, 2003;Hamscher et al, 2002). Animal manures can also be a source of Cu since Cu is a common supplement in animal feed (Ó pezalonso et al, 2000;Hostetler et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community

Kong

Zhu

et al. 2006

Environmental Pollution

211

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Oxytetracycline reduces the functional diversity of soil microbial community, and the combination of Cu and oxytetracycline leads to a further reduction. AbstractThere are increasing concerns over the effects of veterinary antibiotics and heavy metals in agricultural soils. The widely used veterinary antibiotic oxytetracycline (OTC), Cu and their combination on soil microbial community function were assessed with the Biolog method. The microbial community was extracted from the soil and exposed to a 0.85% sodium chloride solution containing OTC (0, 1, 5, 11, 43, 109 and 217 mM), or Cu (0, 10, 20, 100 and 300 mM), or combination of the two pollutants (OTC 0, 5, 11 mM and Cu 0, 20 mM). Functional diversity, evenness, average well color development (AWCD) and substrate utilization decreased significantly with increasing concentrations of OTC or Cu ( p < 0.005). The critical concentrations were 11 mM for OTC and 20 mM for Cu. The combination of OTC and Cu significantly decreased Shannon's diversity, evenness and utilization of carbohydrates and carboxylic acids compared to individual one of the contaminants. The antibiotic OTC and Cu had significant negative effects on soil microbial community function, particularly when both pollutants were present.

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“…OTC is a broad-spectrum antibiotic of the tetracycline family which is widely used in veterinary medicine (De Liguoro et al, 2003;Mahedero et al, 2005;Ja et al, 2008). This pharmaceutical is not efficiently removed by conventional wastewater treatments which results in its frequent detection in treated wastewaters and in water bodies of agricultural regions (Tong et al, 2009;Chen et al, 2012;Cavenati et al, 2012).…”

Section: Otc Removal Efficiencymentioning

confidence: 99%

Constructed wetlands with light expanded clay aggregates for agricultural wastewater treatment

Dordio

Carvalho

2013

Science of The Total Environment

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. H I G H L I G H T S• CW with LECA substrate and Phragmites plants tested with agricultural wastewaters.• High removals of TSS, COD, NH 4 -N, polyphenols, a pharmaceutical and a pesticide.• Contact time of wastewaters with beds ranged from 3 to 9days in batch conditions.• Promising results suggest more studies in full-scale and more realistic conditions. Constructed wetlands (CWs) are receiving a renewed attention as a viable phytotechnology for treating agricultural wastewaters and for the removal of more specific pollutants, in particular recalcitrant ones. In this work, the performance of CW mesocosms using light expanded clay aggregates (LECA) as the bed's substrate and planted with Phragmites australis was investigated for treatment of olive mill wastewater (OMW), swine wastewater (SW) contaminated with oxytetracycline and water contaminated with herbicide MCPA (2-methyl-4-chlorophenoxyacetic acid). Both wastewaters (OMW and SW) initially presented high organic matter content and total suspended solids which were removed by the system with efficiencies higher than 80%. Removal of polyphenols in OMW and nitrogen compounds in SW also showed similar or higher efficiencies in comparison with other treatment systems reported in the literature. The antibiotic oxytetracycline was completely removed from SW within the assay period in unplanted LECA beds, but planted beds allowed a significantly faster removal. In regard to water contaminated with MCPA, the results showed that LECA has a large sorption capacity for this herbicide (removal efficiencies of 56-97%). In general, considerably higher pollutant removal efficiencies were obtained when plants were used (up to 28% higher). The results obtained are indicative that CWs with LECA as substrate may be an adequate option for agricultural wastewater treatment. a b s t r a c t a r t i c l e i n f o

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Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil

Cited by 278 publications

References 19 publications

Validation of the exposure assessment for veterinary medicinal products

Validation of the exposure assessment for veterinary medicinal products

The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community

Constructed wetlands with light expanded clay aggregates for agricultural wastewater treatment

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