Use of oxidised regenerated cellulose/collagen dressings versus standard of care over multiple wound types: A systematic review and meta‐analysis

Chowdhry, Saeed; Nieves-Malloure, Yeni; Camardo, Mark; Robertson, Julie M.; Keys, J.

doi:10.1111/iwj.13625

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Among the dressing family, oxidized regenerated cellulose (ORC)/collagen dressings are associated with promising results to augment wound healing . Statistically, there is a significant increase in percent wound area reduction and wound closure rates in patients receiving ORC/collagen dressings compared with standard dressings.…”

Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

“…188 Among the dressing family, oxidized regenerated cellulose (ORC)/collagen dressings are associated with promising results to augment wound healing. 189 Statistically, there is a significant increase in percent wound area reduction and wound closure rates in patients receiving ORC/collagen dressings compared with standard dressings. Further, the properties of bacterial cellulose (BC) can be tailored to develop a potential composite with accelerated wound healing ability in diabetic wounds.…”

Section: Biomaterial-based Approaches For Woundmentioning

confidence: 99%

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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

Section: Biomaterial-based Approaches For Woundmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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“…Wound interventions have been developed to optimize the wound environment, reduce the burden of bacteria and nonviable tissue, and stimulate expression of growth factors. 7 To address these and other needs of chronic wounds, standard wound care is frequently employed alone or in combination with adjunctive wound treatments.…”

Section: Patient and Wound Evaluations And Standard Carementioning

confidence: 99%

“…Containing collagen and cellulose, Promogran Prizma (3M, St. Paul, MN) and Fibra (3M, St. Paul, MN) work to absorb wound proteases leading to a reduction in overall wound size and increased likelihood of subsequent closure. 7…”

Section: Collagen Dressingsmentioning

confidence: 99%

“…6 Wound interventions have been developed to optimize the wound environment, reduce the burden of bacteria and nonviable tissue, and stimulate expression of growth factors. 7 At a minimum, management of chronic wounds involve local wound care and systemic measures. 8 To promote the healing processes, we often cleanse debride of the wound of any necrotic tissue, offload pressure to the affected area, and utilize dressings that promote a moist wound environment.…”

Section: Patient and Wound Evaluations And Standard Carementioning

confidence: 99%

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Novel Technologies in Chronic Wound Care

et al. 2022

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In Israel, 20% of wounds do not progress to full healing under treatment with conservative technologies of which 1 to 2% are eventually defined as chronic wounds. Chronic wounds are a complex health burden for patients and pose considerable therapeutic and budgetary burden on health systems. The causes of chronic wounds include systemic and local factors. Initial treatment involves the usual therapeutic means, but as healing does not progress, more advanced therapeutic technologies are used. Undoubtedly, advanced means, such as negative pressure systems, and advanced technologies, such as oxygen systems and micrografts, have vastly improved the treatment of chronic wounds. Our service specializes in treating ulcers and difficult-to-heal wounds while providing a multiprofessional medical response. Herein, we present our experience and protocols in treating chronic wounds using a variety of advanced dressings and technologies.

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