Use of over-the-counter laxatives by community-dwelling adults to treat and prevent constipation: a national cross-sectional study

Werth, Barry; Williams, Kylie; Fisher, Murray; Pont, Lisa G.

doi:10.1007/s00228-020-02865-5

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…Senna leaves and fruit contains natural laxative agents which is a major method to prevent constipation. Furthermore, according to recent guidelines that address the use of laxatives for both treatment and prevention, and an increase in the involvement of healthcare professionals, an appropriate choice and use of laxatives may be required to improve constipation management in the community ( Werth et al, 2020 ).…”

Section: Health Benefits and Medicinal Usesmentioning

confidence: 99%

Senna: As immunity boosting herb against Covid-19 and several other diseases

Imran¹,

Khalid²,

Saeed³

et al. 2023

Journal of Herbal Medicine

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Section: Health Benefits and Medicinal Usesmentioning

confidence: 99%

Senna: As immunity boosting herb against Covid-19 and several other diseases

Imran¹,

Khalid²,

Saeed³

et al. 2023

Journal of Herbal Medicine

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“…Constipation is one of the most common gastrointestinal disorders, and it is estimated that up to one third of people over 65 years are affected by constipation during their lifetime [ 1 ]. Laxatives are the mainstay of constipation management and are commonly used by old people for both treatment and prevention of constipation [ 2 ]. Laxatives may cause electrolyte and serum potassium imbalance that negatively affect the renal and cardiovascular systems and can be life threatening [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching

et al. 2023

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Background Constipation was associated with incidence of dementia and cognitive decline. Laxatives are the mainstay of constipation management and are commonly used among older populations for both treatment and prevention of constipation. However, the association between use of laxatives and incident dementia, and whether laxatives use may modify the effect of genetic predisposition on dementia remains unclear. Methods We applied 1:3 propensity score matching to balance the baseline characteristics of the laxative users versus non-users and to reduce potential confounders using multi-variates adjusted Cox hazards regression models. We categorized genetic risk into three groups (low, middle, and high) through a genetic risk score of common genetic variants. Information on laxatives use was assessed at baseline and categories into four varieties, including bulk forming laxatives, softeners and emollients, osmotic laxatives, and stimulant laxatives. Results Of 486,994 participants, there were 14,422 laxatives users in UK Biobank. After propensity score matching, participants with use of laxatives (n = 14,422) and matched non-laxative (n = 43,266) exposed individuals were enrolled. Over follow-up to 15 years, there were 1377 participants developed dementia (539 for Alzheimer’s disease, and 343 for vascular dementia). The use of laxatives had greater risk of dementia (HR, 1.72; 95% CI:1.54–1.92), Alzheimer’s disease (HR, 1.36; 95% CI: 1.13–1.63), and vascular dementia (HR, 1.53; 95% CI: 1.23–1.92). Compared to non-laxative exposed participants, those with use of softeners and emollients drugs, stimulant laxatives, and osmotic laxatives were associated with 96% (HR, 1.96; 95 CI: 1.23–3.12; P = 0.005), 80% (HR, 1.80; 95% CI: 1.37–2.37; P < 0.001), and 107% (HR, 2.07; 95% CI: 1.47–2.92; P < 0.001) higher risk of developed incident dementia, respectively. In joint effect analysis, compared to participants with low/middle genetic susceptibility and non-laxatives use, the HR (95% CIs) of dementia was 4.10 (3.49–4.81) for those with high genetic susceptibility plus use of laxatives. There was an additive interaction between laxatives use and genetic susceptibility on dementia (RERI: 0.736, 95% CI: 0.127 to 1.246; AP: 0.180, 95% CI: 0.047 to 0.312). Conclusions Use of laxatives was associated with higher risk of dementia and modify the effect of genetic susceptibility on dementia. Our findings suggested that attention should be paid to the relationship between laxatives use and dementia, especially in people at high genetic susceptibility.

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“…Laxatives have the properties of accelerating or stimulating defecation and are used for many purposes in the community, especially for constipation management. Laxatives generally show this effect by three different mechanisms (3,4). Mechanism pathways: (i) enhancing fluid retention through hydrophilic or osmotic mechanisms; (ii) reducing the net absorption of fluid through effects on small and large intestinal fluid and electrolyte transport; or (iii) segmentation is to alter mobility by inhibiting (non-impulsive) contractions or by stimulating repulsive contractions.…”

mentioning

confidence: 99%

THE RELATIONSHIP OF WRONG LAXATIVE USE WITH CONSTIPATION AND EATING DISORDERS in vitro: EFFECT ON HEALTHY COLON EPITHELI

KESKİNER

DAL²

2023

Acibadem Univ Saglik Bilim Derg

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Objective: It is estimated that the use of wrong laxatives will increase the probability of developing an eating disorder by affecting the disorder in eating behavior and the physiological disorder of digestion. Long-term use of laxatives is known by many to impair normal colonic function and producing laxative dependence. In our study, it was aimed to determine the effect of the Folliculj sennae plant, which is used for laxative and slimming purposes, on the CCD-18Co (normal colon epithelium) cell line. Materials and Methods: The effect of Folliculj sennae plant. Its antiproliferative effect on CCD-18Co cell line was determined by MTT test. Results: According to the concentrations used in the CCD-18Co cell line, the % viability activities were determined between 73 and 54 and the 50% inhibitory concentration value (IC50) was calculated as 47 ppm. Conclusion: It is thought that the Folliculj sennae plant, which is used as a laxative and has a negative effect on the CCD18-Co cell line, will make an important contribution by health professionals to raise the awareness of their patients about laxatives.

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Use of over-the-counter laxatives by community-dwelling adults to treat and prevent constipation: a national cross-sectional study

Cited by 7 publications

References 39 publications

Senna: As immunity boosting herb against Covid-19 and several other diseases

Senna: As immunity boosting herb against Covid-19 and several other diseases

Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching

THE RELATIONSHIP OF WRONG LAXATIVE USE WITH CONSTIPATION AND EATING DISORDERS in vitro: EFFECT ON HEALTHY COLON EPITHELI

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