2021
DOI: 10.1016/j.injury.2021.01.030
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Use of Osteobiologics for Fracture Management: The When, What, and How

Abstract: Osteobiologics are defined as a group of natural and synthetic materials used to augment bone healing. The selection of the most appropriate osteobiologic from the growing list of available options can be a challenging task. In selecting a material, surgeons should weigh a variety of considerations, including the indication for their use (the when), the most suitable substance (the what), and the correct mode of application (the how). This summary reviews these considerations and seeks to provide the surgeon w… Show more

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Cited by 4 publications
(3 citation statements)
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References 144 publications
(114 reference statements)
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“…Такое расширение свойств костнопластических материалов может быть вполне оправдано, т.к. увеличивает возможности выбора материала хирургом [48].…”
Section: таблица 6 нежелательные явления отмеченные в экспериментальн...unclassified
“…Такое расширение свойств костнопластических материалов может быть вполне оправдано, т.к. увеличивает возможности выбора материала хирургом [48].…”
Section: таблица 6 нежелательные явления отмеченные в экспериментальн...unclassified
“…The present gold standard for bone reconstruction is still the autograft (“transposition of a patient's bone from a distant region of the body to the site of the bony defect” [ 4 ]) – anterior iliac crest bone graft, and effectiveness of all osteobiologics is measured against it. Allografts, and xenografts are also used [ 3 , [5] , [6] , [7] , [8] , [9] ].…”
Section: Introductionmentioning
confidence: 99%
“…Osteopromocação é uma barreira na qual impede a migração de células não osteogênicas para que promova a formação óssea (Saska et al, 2018). Enquanto a osteocondução são materiais que fornecem um ambiente favorável na qual ocorra o crescimento ósseo (Marmor, Matz, McClellan, Medam, & Miclau, 2021). A osteoindução são materiais que possuem propriedades bioativas, ou seja, elas induzem a diferenciação de células-tronco mesenquimais em osteoblastos, que são células responsáveis na produção óssea e temos a osteogênese que são materiais que trazem células ósseas vivas do seu interior, que agem como um autoenxerto, fazendo com o que ocorra a formação do osso (Marmor et al, 2021).…”
Section: Introductionunclassified