Use of oseltamivir during an outbreak of influenza A in a long-term care facility in Taiwan

Chang, Yuan-Chia; Li, W.-C.; Huang, Chung‐Guei; Tsao, Kuo Chien; Cheng, Yuli; Chiang, Shang Lin; Yang, Shijiang; Chen, C.-H.; Huang, Yhu Chering

doi:10.1016/j.jhin.2007.08.022

Cited by 20 publications

(6 citation statements)

References 17 publications

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“…This assumption is in agreement with the recently published systematic review on influenza outbreak control practices and the effectiveness of interventions in long-term care facilities, indicating that pharmacological control measures have the clearest reported protective effect [18]. A similar effect of oseltamivir treatment and prophylaxis on the reduction of influenza outbreak duration in residents of NHs has also been recently reported by Booy et al [19] and is further supported by other studies [20][21][22][23][24]. A model-based study by van den Dool et al [25] showed that postexposure oseltamivir prophylaxis in NH residents during outbreak reduces the number of influenza cases, prevents larger outbreaks and that the selection pressure for oseltamivir resistance is lower than for continuous oseltamivir prophylaxis.…”

Section: Discussionsupporting

confidence: 90%

Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches

Miksić

Uršič²,

Simonović³

et al. 2014

Infection

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Section: Discussionsupporting

confidence: 90%

Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches

Miksić

Uršič²,

Simonović³

et al. 2014

Infection

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“…One observational study described successful use of oseltamivir chemoprophylaxis to control 5 influenza outbreaks in long-term care residents after use of amantadine failed to contain the outbreaks [442]. Other studies have described the use of oseltamivir or zanamivir chemoprophylaxis for 7–14 days [407–410, 439, 440, 451, 454].…”

Section: Institutional Outbreak Controlmentioning

confidence: 99%

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa

Uyeki

Bernstein

Bradley

et al. 2018

Clinical Infectious Diseases

519

360

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These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic testing, treatment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak management for seasonal influenza. It is intended for use by primary care clinicians, obstetricians, emergency medicine providers, hospitalists, laboratorians, and infectious disease specialists, as well as other clinicians managing patients with suspected or laboratory-confirmed influenza. The guidelines consider the care of children and adults, including special populations such as pregnant and postpartum women and immunocompromised patients.

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“…Most work evaluating influenza control measures has focused on vaccination and antivirals, reported direct vaccine effectiveness in a single LTCF after a seasonal outbreak, [5][6][7][8][9][10][11][12][13][14][15][16] or used a randomized controlled trial (RCT) design where individuals or facilities randomized to receive an intervention were compared with those receiving a placebo or the standard of care. [17][18][19][20][21] While these studies are essential to establishing the effectiveness of interventions, several gaps in our understanding of the effectiveness of control measures remain.…”

Section: Introductionmentioning

confidence: 99%

Influenza outbreak control practices and the effectiveness of interventions in long‐term care facilities: a systematic review

Rainwater-Lovett

Chun

Lessler

2013

Influenza Resp Viruses

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Summary Background Evaluation of influenza control measures frequently focuses on the efficacy of chemoprophylaxis and vaccination while the effectiveness of non-pharmaceutical interventions (NPI) receives less emphasis. While influenza control measures are frequently reported for individual outbreaks, there have been few efforts to characterize the real-world effectiveness of these interventions across outbreaks. Objectives To characterize influenza case and outbreak definitions and control measures reported by long-term care facilities (LTCFs) of elderly adults, and estimate the reduction in influenza-like illness (ILI) attack rates due to chemoprophylaxis and NPI. Methods We conducted a literature search in PubMed including English-language studies reporting influenza outbreaks among elderly individuals in LTCFs. A Bayesian hierarchical logistic regression model estimated the effects of control measures on ILI attack rates. Results Of 654 articles identified in the literature review, 37 articles describing 60 influenza outbreaks met the inclusion criteria. Individuals in facilities where chemoprophylaxis was used were significantly less likely to develop influenza A or B than those in facilities with no interventions (odds ratio [OR] 0.48, 95% CI: 0.28, 0.84). Considered by drug class, adamantanes significantly reduced infection risk (OR 0.22, 95% CI: 0.12, 0.42) while neuraminidase inhibitors did not show a significant effect. Although NPI showed no significant effect, the results suggest that personal protective equipment may produce modest protective effects. Conclusions Our results indicate pharmaceutical control measures have the clearest reported protective effect in LTCFs. Non-pharmaceutical approaches may be useful; however, most data were from observational studies and standardized reporting or well-conducted clinical trials of NPI are needed to more precisely measure these effects.

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Use of oseltamivir during an outbreak of influenza A in a long-term care facility in Taiwan

Cited by 20 publications

References 17 publications

Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches

Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa

Influenza outbreak control practices and the effectiveness of interventions in long‐term care facilities: a systematic review

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