Use of Oral Cortisone in Paediatrics

Abstract

SIMPLE GASTRIC ULCER AND CARCINOMA BDI ouIL pre-pyloric carcinomata frequently undergo peptic ulceration and may then present with the histological features of so-called " ulcer-cancer." We believe that the second possibility is inherently more likely. But, in any event, from a practical standpoint the main conclusion is unaffected by one's choice between these two possibilities. It is that pre-pyloric ulcers are commonly malignant and should be resected. SummaryAmong 375 patients with gastric carcinoma treated in the Radcliffe Infirmary there were 26 with some eviqence that the neoplasm might have arisen in a simple ulcer.There was good clinical evidence of chronic simple ulcer in only half the patients.The site of the neoplasm for the group -of 26 patients conformed with the distribution of carcinoma of the stomach and not with that of simple gastric ulcer.In three cases the carcinoma had apparently arisen at a site different from that of a pre-existing simple ulcer.We believe that most of these cases were examples of ulcerating carcinoma. In any event, the majority were prepyloric, and it is evident that pre-pyloric ulcers should be deemed malignant and treated by surgical resection.We wish to thank the physicians and surgeons of the Radcliffe Infirmary for permission to make the study out of which the present article arises.

Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Introduction

“…Oral and intra-articular administration of cortisone and hydrocortisone began in 1950-1951, while the semisynthetic production of cortisone started in 1952. Pediatric experience with corticosteroids also started in these years: for example, in 1951 the British Medical Journal described fi ve children (three with rheumatoid arthritis, one with acute rheumatic carditis, one with nephrosis) treated with oral cortisone [ 5 ]. In the same year, seven other children with nephrotic syndrome were treated with cortisone [ 6 ].…”