Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age

Słopień, Radosław; Milewska, Ewa; Rynio, Piotr; Męczekalski, Błażej

doi:10.5114/pm.2018.74895

Cited by 15 publications

(25 citation statements)

References 42 publications

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“…Finally, the present study is limited by the lack of information on certain biological markers, such as triglycerides, insulin, or C-reactive protein, or other lifestyle-related variables or dietary factors that may interfere with the associations found. Regarding this last point, it is worth noting the possible effect of certain preparations of isoflavones, calcium, vitamin D and insulin, since it has been observed that these could modify the metabolic parameters and body composition of women [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women

et al. 2020

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This study investigates the still uncertain association between serum phospholipid fatty acids (PL-FA), and anthropometric and adiposity variables. A cross-sectional study was conducted with 1443 Spanish premenopausal women. Participants answered an epidemiological and a food frequency questionnaire. Anthropometric variables were measured using a bioimpedance scale. Serum PL-FAs levels were determined by gas chromatography–mass spectrometry. The association between body mass index (BMI), weight gain, body fat percentage, visceral fat index, and waist circumference with serum PL-FAs and desaturation indices was evaluated using multivariable linear regression models. BMI was positively associated with the relative concentration of saturated fatty acids (SFAs) (β = 0.94, q-val = 0.001), and with palmitoleic, dihomo-γ-linolenic (DGLA), arachidonic (AA) and α-linolenic acids, and was inversely associated with oleic, gondoic, trans-vaccenic, linoleic and γ-linolenic acids. Total fat percentage was positively associated with DGLA and AA, and inversely with linoleic and γ-linolenic acids. Low relative concentrations of some SFAs and high levels of n-6 PUFAs were associated with greater waist circumference. While the oleic/stearic and AA/DGLA acid ratios were inversely associated with BMI, DGLA/linoleic acid ratio was positively related to almost all variables. In addition to BMI, total fat percentage and waist circumference were also associated with certain individual fatty acids.

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Section: Discussionmentioning

confidence: 99%

Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women

et al. 2020

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“…To summarize the use of hormonal therapy in menopausal acne is an effective option which improves the quality of life, but it should be initiated only after proper evaluation and exclusion of contraindications. Though it is relatively safe, possible serious complications can occur and should be discussed with the patient 60. Patients on hormonal therapy must also be monitored regularly to detect adverse effects.…”

Section: Methodsmentioning

confidence: 99%

<p>Menopausal Acne – Challenges And Solutions</p>

Khunger¹,

Mehrotra²

2019

IJWH

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Although acne is a disease predominant in adolescence, it is being increasingly observed in adult life, including the menopausal period. The etiology of menopausal acne is multifactorial, with hormonal imbalance being the major culprit. There is a relative increase of androgens in the menopausal female that leads to clinical hyperandrogenism manifesting as acne, hirsutism and androgenetic alopecia. Other endocrine disorders including thyroid abnormalities, hyperprolactinemia and insulin resistance also play a role. Genetics, stress, dietary changes, lack of sleep and exercise and other lifestyle changes are implicated as trigger factors. Most menopausal women with isolated few acne lesions have normoandrogenic serum levels and do not require extensive investigations. However, baseline investigations including total testosterone are useful. Patients must also be evaluated for associated comorbidities such as obesity, diabetes, hypertension and dyslipidemia. A detailed history can help to exclude polycystic ovarian syndrome, late-onset congenital adrenal hyperplasia or medications as a cause of acne. The evaluation of menopausal acne and the approach to treatment depend on the severity of acne and associated features. In patients with mild acne without virilization, prolonged topical therapy is the mainstay of treatment. Though combined oral contraceptives are effective, they are relatively contraindicated in the postmenopausal period. Spironolactone is the first choice of therapy in the subset of patients that require oral anti-androgen therapy. Procedural treatment can be useful as it can also help in the treatment of associated acne scars and concomitant skin aging. It is also important to focus on lifestyle changes such as reducing stress, controlling obesity, having a healthy diet, exercise and proper skin care routine to reduce acne. The focus of this article is on the clinical presentation and management challenges of menopausal acne, which represents a special subtype of acne.

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“…Both components of combined contraception lower the levels of adrenocorticotropic hormone that in consequence has inhibitory effect on adrenal androgenesis. 6 In our study, the better effect of LNG/EE than LNG in acne and hirsutism patients because EE has antiandrogenic effect than LNG which is considered the most andro- Estroprogestins (Eps) as being linked to a lower VTE risk than EPs containing other progestins. 45…”

Section: Discussionmentioning

confidence: 67%

Levonorgestrel vs combined oral contraceptive pills in treatment of female acne and hirsutism

Moubasher

Basset

Khalil³

et al. 2020

Dermatologic Therapy

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Combined oral contraception was used in many studies for treatment of acne and hirsutism. However, levonorgestrel (LNG) alone has not been evaluated before. Our objective is to evaluate the efficacy of oral contraceptive (OC) pills containing LNG and ethinyl estradiol (EE) compared with LNG only for the treatment of acne and hirsutism in a randomized, controlled prospective clinical trial. Eighty females (20 with acne, 20 with hirsutism, and 40 healthy females) received LNG + EE or LNG only for 6 months. Assessment of acne by global acne grading system (GAGS) and hirsutism by modified Ferriman-Gallwey scale (MFGS) grading system and serum free testosterone was measured before and 6 months after treatment. Serum free testosterone was significantly higher before treatment in acne and hirsutism patients compared to control group

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Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age

Cited by 15 publications

References 42 publications

Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women

Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women

<p>Menopausal Acne – Challenges And Solutions</p>

Levonorgestrel vs combined oral contraceptive pills in treatment of female acne and hirsutism

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